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Protein

DNA topoisomerase 2

Gene

TOP2

Organism
Emericella nidulans (Aspergillus nidulans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2UniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:TOP2Imported
OrganismiEmericella nidulans (Aspergillus nidulans)Imported
Taxonomic identifieri162425 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi162425.CADANIAP00003686.

Structurei

3D structure databases

ProteinModelPortaliO59864.
SMRiO59864. Positions 118-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini544 – 658115ToprimInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation
Contains 1 Toprim domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0355. Eukaryota.
COG0187. LUCA.
COG0188. LUCA.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR031660. TOPRIM_C.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00521. DNA_topoisoIV. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
PF16898. TOPRIM_C. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
SM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiPS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDDSLMGS VFSDDGSSDF MTDEAPKPKK AAKKAAPKKA PAKKAAVKPK
60 70 80 90 100
KKAKADSEDE MSDPDDPLDV DSVLSQTPPK KVPAAATKKS GFKPLADVEN
110 120 130 140 150
ESIPIDDVDA SEEVKASSKY QKLNLREHIT IRPDSYIGSV ERTTQEMWVY
160 170 180 190 200
NSEIDGMEFR EVSYVPGLYK IFDEIVVNAA DNKQNDDNMD EIRVTYSRET
210 220 230 240 250
NEISVWNNGK GIPVEMHEEH GMYIPQLIFG NLLTSSNYDD AKEKITGGRN
260 270 280 290 300
GFGAKLCNVF STEFTVETQD SKQKKRYLQT WTDNMQTVGK PKITAAKGSD
310 320 330 340 350
FTRVTFKADF PRFGMDGIDD DFEALIKRRV YDLAGTTGVT VKLNGTRLPV
360 370 380 390 400
RNFKKYMEMY TKAIRRERGD DDSKSDPIIT CSPHPYWEIG FAVSDGSFKQ
410 420 430 440 450
VSFVNSIATT SGGTHVNYIA DQIAGKLSES LKKNKKGTGS ILKPAQIRNY
460 470 480 490 500
CFLFVNAKIV NPAFSSQTKE QLTTKQTQFG SKPILDESFL KKVANSGVLD
510 520 530 540 550
SLKRFADHKA DLMLKKSDGG RRSRMNNPKL TDANRAGTKD GYKCTLILTE
560 570 580 590 600
GESAKGLAMA GRAVVGADLF GVYPLRGKML NVRDASFDQI SKNEEIQSIK
610 620 630 640 650
NFMGLQHKKE YTDTKGLRYG HLMIMTDQDH DGSHIKGLLI NFLEAQFPSL
660 670 680 690 700
LKIPEFLIEF ITPIVKVWKG DIKDPTKQHS FFTIQEYNAW KEKHGHERGW
710 720 730 740 750
EHKYYKGLGT SSTEEAQEYF RDLDRHLKEF HVMQDKEHEL IELAFSKKKV
760 770 780 790 800
EERKEWLRQY NPDTFMDHSV AKISYTDFIN NELIQFSMAD NLRSIPSMVD
810 820 830 840 850
GMKPGQRKVM YTVMKRNIKK DVKVLDLTGQ VFSLTAYHHG DASMHQTIIG
860 870 880 890 900
LAQDFVGSNN VNTLEPSGNF GSRLKGGADA SSARYIHTRL SPFARKIFHP
910 920 930 940 950
HDDPILKYLE DDGKEIEPWV YVPVVPMILI NGADGIGTGW STSIPNYNPE
960 970 980 990 1000
DIVDNLKRMI RGEEIKPMQP WFKGFKGEVT QLGPDKYKFS GLIKQVSDKE
1010 1020 1030 1040 1050
LEVTELPIRT WTQDFINKLE EMIKADKAPS LIKDYKDYNT NSDVHLVLQL
1060 1070 1080 1090 1100
DEKNVKEPLT QEFLEEKFKL SKTIATTNLV AFNAEGQMTK YPNVEAILEE
1110 1120 1130 1140 1150
FYRLRLKFYG KRKQHQLDQL QIELEKLTNQ ARFVHMIIDG DLVVSKKKKS
1160 1170 1180 1190 1200
VLVKELDSLG FKRFNKTADA AKAGETEKVI EASEDEDTEA QDDTQDLAHA
1210 1220 1230 1240 1250
FDYLLGMAIW SLTQERVEKL RRQIGEKEHE IDELIKLSSE DIWLRDLDEF
1260 1270 1280 1290 1300
INEWRFQLSE TDRRRRGQQK KGRRVSTKLA TAARAVGGKK RKAAGDDSDD
1310 1320 1330 1340 1350
DFVVSKSKKK AAANKTEPAG GIMSFLKKTP KPEPAANDSD SDSDFGFGIE
1360 1370 1380 1390 1400
EVMPKKSRGP VKASPQLKDE DGDLDMEASE VEVAPKKSRG PPKAAPKAAA
1410 1420 1430 1440 1450
KLKDEDKDED EPKVKPVTKR GRPAKPKPKD DDSDGLDDDE FMEIAKAEAA
1460 1470 1480 1490 1500
KTAPPRAGRK AAPKYTLDDS DSDNGDDLLG DVSKMVKGIG GAAGGSATDS
1510 1520 1530 1540 1550
RQLFSELSRP GSSTGLPTNS KTSKFDNDFD ADETDYSKLI PQNSPRRSLQ
1560 1570 1580 1590 1600
VKPKDVKASE SIDLDDEEDK PIKPAKTKAA PKAKAAPAPK AGTGKGRGRP
1610 1620 1630 1640 1650
KKDATAIASS LKQTTLPPAA KAYASKQAKG ASTASKKKTL MDDSEDDIDA
1660 1670 1680 1690 1700
MANDILDSPV GIRDEAPAPP RSTASRPSRR TTTKKSYVIE DDDSEDGADN

QDDSFDLSD
Length:1,709
Mass (Da):190,872
Last modified:December 21, 2004 - v2
Checksum:iE6EC885EED82D376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014886 Genomic DNA. Translation: BAA28664.2.
PIRiT30516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014886 Genomic DNA. Translation: BAA28664.2.
PIRiT30516.

3D structure databases

ProteinModelPortaliO59864.
SMRiO59864. Positions 118-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00003686.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0355. Eukaryota.
COG0187. LUCA.
COG0188. LUCA.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR031660. TOPRIM_C.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00521. DNA_topoisoIV. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
PF16898. TOPRIM_C. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
SM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiPS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Kim K., Akashi T., Mizuguchi I., Kikuchi A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning and characterization of the gene encoding Aspergillus nidulans DNA topoisomerase II."
    Kim K.H., Akashi T., Mizuguchi I., Kikuchi A.
    Gene 236:293-301(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO59864_EMEND
AccessioniPrimary (citable) accession number: O59864
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.