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Protein

Glutathione peroxidase

Gene

gpx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Constitutes a glutathione peroxidase-like protective system against oxidative stresses. Acts as a scavenger of H2O2.1 Publication

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36By similarity1

GO - Molecular functioni

  • thioredoxin peroxidase activity Source: PomBase

GO - Biological processi

  • cell redox homeostasis Source: PomBase
  • cellular response to hydrogen peroxide Source: PomBase
  • cellular response to osmotic stress Source: PomBase
  • hydrogen peroxide catabolic process Source: PomBase
  • sulfur compound metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-SPO-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-SPO-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-SPO-3299685. Detoxification of Reactive Oxygen Species.
R-SPO-5628897. TP53 Regulates Metabolic Genes.
R-SPO-74259. Purine catabolism.

Protein family/group databases

PeroxiBasei3744. SpomGPx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase (EC:1.11.1.9)
Gene namesi
Name:gpx1
ORF Names:SPBC32F12.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC32F12.03c.
PomBaseiSPBC32F12.03c. gpx1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrion Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666441 – 158Glutathione peroxidaseAdd BLAST158

Proteomic databases

MaxQBiO59858.
PRIDEiO59858.

Expressioni

Inductioni

By oxidative, osmo- and heat stress.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi276755. 12 interactors.
MINTiMINT-4676657.

Structurei

3D structure databases

ProteinModelPortaliO59858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

HOGENOMiHOG000277054.
InParanoidiO59858.
KOiK00432.
OMAiTFYQLTA.
OrthoDBiEOG092C4H0P.
PhylomeDBiO59858.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHFYDLAPK DKDGNPFPFS NLKGKVVLVV NTASKCGFTP QYKGLEALYQ
60 70 80 90 100
KYKDRGFIIL GFPCNQFGNQ EPGSDEEIAQ FCQKNYGVTF PVLAKINVNG
110 120 130 140 150
DNVDPVYQFL KSQKKQLGLE RIKWNFEKFL VNRQGQVIER YSSISKPEHL

ENDIESVL
Length:158
Mass (Da):18,061
Last modified:August 1, 1998 - v1
Checksum:i2D7009280B676876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012395 Genomic DNA. Translation: BAA25326.1.
CU329671 Genomic DNA. Translation: CAA19364.1.
PIRiT43376.
RefSeqiNP_596146.1. NM_001022065.2.

Genome annotation databases

EnsemblFungiiSPBC32F12.03c.1; SPBC32F12.03c.1:pep; SPBC32F12.03c.
GeneIDi2540222.
KEGGispo:SPBC32F12.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012395 Genomic DNA. Translation: BAA25326.1.
CU329671 Genomic DNA. Translation: CAA19364.1.
PIRiT43376.
RefSeqiNP_596146.1. NM_001022065.2.

3D structure databases

ProteinModelPortaliO59858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276755. 12 interactors.
MINTiMINT-4676657.

Protein family/group databases

PeroxiBasei3744. SpomGPx01.

Proteomic databases

MaxQBiO59858.
PRIDEiO59858.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC32F12.03c.1; SPBC32F12.03c.1:pep; SPBC32F12.03c.
GeneIDi2540222.
KEGGispo:SPBC32F12.03c.

Organism-specific databases

EuPathDBiFungiDB:SPBC32F12.03c.
PomBaseiSPBC32F12.03c. gpx1.

Phylogenomic databases

HOGENOMiHOG000277054.
InParanoidiO59858.
KOiK00432.
OMAiTFYQLTA.
OrthoDBiEOG092C4H0P.
PhylomeDBiO59858.

Enzyme and pathway databases

ReactomeiR-SPO-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-SPO-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-SPO-3299685. Detoxification of Reactive Oxygen Species.
R-SPO-5628897. TP53 Regulates Metabolic Genes.
R-SPO-74259. Purine catabolism.

Miscellaneous databases

PROiO59858.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX1_SCHPO
AccessioniPrimary (citable) accession number: O59858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.