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O59854 (HOG1_ZYGRO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase HOG1

Short name=MAP kinase HOG1
EC=2.7.11.24
Alternative name(s):
ZrHOG1
Gene names
Name:HOG1
OrganismZygosaccharomyces rouxii (Candida mogii)
Taxonomic identifier4956 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Mitogen-activated protein kinase HOG1
PRO_0000289710

Regions

Domain23 – 302280Protein kinase
Nucleotide binding29 – 379ATP By similarity
Motif174 – 1763TXY

Sites

Active site1441Proton acceptor By similarity
Binding site521ATP By similarity

Amino acid modifications

Modified residue1741Phosphothreonine By similarity
Modified residue1761Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
O59854 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D72200C243B4114E

FASTA40746,428
        10         20         30         40         50         60 
MATHEEFIRT QVFGTVFEIT NRYTDLNPVG MGAFGLVCSA TDTLAGQPVA IKKIMKPFST 

        70         80         90        100        110        120 
AVLAKRTYRE LKLLKHLRHE NLICLQDIFL SPLEDIYFVT ELQGTDLHRL LQTRPLEKQF 

       130        140        150        160        170        180 
VQYFLYQILR GLKYVHSAGV IHRDLKPSNI LINENCDLKI CDFGLARIQD PQMTGYVSTR 

       190        200        210        220        230        240 
YYRAPEIMLT WQKYDVEVDI WSAGCIFSEM IEGKPLFPGK VHVHQFSIIT DLLGSPPRDV 

       250        260        270        280        290        300 
IITICSEDTL KFVTSLPHRD PVPFQERFKA VEPDAVDLLG RMLVFDPKKR ITAADALVHP 

       310        320        330        340        350        360 
YLAPYHDPTD EPIAEAQFDW DFNDADLPVD TWRVMMYSEI LDFHKIGGSD GQIDTNAAFD 

       370        380        390        400 
DQVAAATAGP MLPLWLNSNI NINNSHPVNI QVQLLRHQQP RITVVYQ 

« Hide

References

[1]"Two putative MAP kinase genes, ZrHOG1 and ZrHOG2, cloned from the salt-tolerant yeast Zygosaccharomyces rouxii are functionally homologous to the Saccharomyces cerevisiae HOG1 gene."
Iwaki T., Tamai Y., Watanabe Y.
Microbiology 145:241-248(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: ATCC 42981 / IAM 12879 / JCM 22060 / S-96.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB012146 Genomic DNA. Translation: BAA25200.1.

3D structure databases

ProteinModelPortalO59854.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_ZYGRO
AccessionPrimary (citable) accession number: O59854
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families