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Protein

Probable cytosine deaminase

Gene

SPCC965.14c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.By similarity

Catalytic activityi

Cytosine + H2O = uracil + NH3.By similarity

Cofactori

Zn2+By similarity

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from cytosine.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable cytosine deaminase (SPCC965.14c)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from cytosine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Zinc; catalyticBy similarity1
Active sitei61Proton donorBy similarity1
Metal bindingi87Zinc; catalyticBy similarity1
Metal bindingi90Zinc; catalyticBy similarity1
Binding sitei159SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00574; UER00635.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosine deaminase (EC:3.5.4.1)
Alternative name(s):
Cytosine aminohydrolase
Gene namesi
ORF Names:SPCC965.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC965.14c.
PomBaseiSPCC965.14c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108311 – 162Probable cytosine deaminaseAdd BLAST162

Proteomic databases

MaxQBiO59834.
PRIDEiO59834.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi276153. 5 interactors.
MINTiMINT-4676577.

Structurei

3D structure databases

ProteinModelPortaliO59834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 132CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST125

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.Sequence analysis
Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000085050.
InParanoidiO59834.
OMAiIECIGPA.
OrthoDBiEOG092C50AY.
PhylomeDBiO59834.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTELSEKD LAYLREAIKV SQQARDEGQH PFGCIIVDEN DNVIMSAGNR
60 70 80 90 100
VPDGDVTQHA ETRAVGLITK TRRDLEKCTL YTSTEPCAMC SGAIFWSGIR
110 120 130 140 150
RMIFGLSNEN LIKLTQKSGE CPPLYINSRD ILGAASHPIE VVGPYIEDEA
160
IIPHKGFWDG GR
Length:162
Mass (Da):17,882
Last modified:August 1, 1998 - v1
Checksum:i5CF5389CE67308D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19074.1.
PIRiT41667.
RefSeqiNP_588524.1. NM_001023513.2.

Genome annotation databases

EnsemblFungiiSPCC965.14c.1; SPCC965.14c.1:pep; SPCC965.14c.
GeneIDi2539595.
KEGGispo:SPCC965.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19074.1.
PIRiT41667.
RefSeqiNP_588524.1. NM_001023513.2.

3D structure databases

ProteinModelPortaliO59834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276153. 5 interactors.
MINTiMINT-4676577.

Proteomic databases

MaxQBiO59834.
PRIDEiO59834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC965.14c.1; SPCC965.14c.1:pep; SPCC965.14c.
GeneIDi2539595.
KEGGispo:SPCC965.14c.

Organism-specific databases

EuPathDBiFungiDB:SPCC965.14c.
PomBaseiSPCC965.14c.

Phylogenomic databases

HOGENOMiHOG000085050.
InParanoidiO59834.
OMAiIECIGPA.
OrthoDBiEOG092C50AY.
PhylomeDBiO59834.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00635.

Miscellaneous databases

PROiO59834.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCYS_SCHPO
AccessioniPrimary (citable) accession number: O59834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.