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O59832

- DPEH2_SCHPO

UniProt

O59832 - DPEH2_SCHPO

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Protein

Uncharacterized dipeptidase C965.12

Gene

SPCC965.12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zinc.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi31 – 311Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi144 – 1441Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi144 – 1441Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi215 – 2151Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi236 – 2361Zinc 2; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. dipeptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_193583. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized dipeptidase C965.12 (EC:3.4.13.19)
Gene namesi
ORF Names:SPCC965.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC965.12.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Uncharacterized dipeptidase C965.12PRO_0000314655Add
BLAST

Proteomic databases

MaxQBiO59832.

Interactioni

Protein-protein interaction databases

MINTiMINT-4676557.
STRINGi4896.SPCC965.12-1.

Structurei

3D structure databases

ProteinModelPortaliO59832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2355.
HOGENOMiHOG000072016.
InParanoidiO59832.
KOiK01273.
OMAiRNDINGQ.
OrthoDBiEOG7XM371.
PhylomeDBiO59832.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59832-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVDLREEKE LAQQRFKEIC KHAKIVDTHN DFPYLLRVQL RNKLQLAEFD
60 70 80 90 100
FENGLTSHTD LVKMRQGQVG VQFFSCFIEC KNPNYLYQDF DTPTTVVRDT
110 120 130 140 150
LEQIDVTRRL VCKYNNDLKF VDCADDAIAA FRNNGKIAIA LGVEGLHQVD
160 170 180 190 200
TSLAVLRQYY SLGVRYITLT HNCDNPFATA ASSITGGLPD RGLSAYGIEC
210 220 230 240 250
IFEMNRLGMM VDLSHVSHRT MHDALDVTKA PVIFSHSSAY TLTEHERNVR
260 270 280 290 300
DDVLERLKTN GGVVQVNFYQ DFIRKPGSDR ATIDDAADHI LHIIKVAGWE
310 320 330 340 350
HVGLGSDFDG IPQGPKGLED VSKYPDLICK IIERTNATNE QIEGLMGLNV
360 370 380 390 400
LRVWKKTELV ALQLSKKLEP IESSWSGRKW EFYSYAKEFP ELFPDAYKLN
410
EKSTVWNYDQ PLNIEK
Length:416
Mass (Da):47,421
Last modified:August 1, 1998 - v1
Checksum:i8EB843F4C662D625
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA19072.1.
RefSeqiNP_588522.1. NM_001023511.2.

Genome annotation databases

EnsemblFungiiSPCC965.12.1; SPCC965.12.1:pep; SPCC965.12.
GeneIDi2539107.
KEGGispo:SPCC965.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA19072.1 .
RefSeqi NP_588522.1. NM_001023511.2.

3D structure databases

ProteinModelPortali O59832.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4676557.
STRINGi 4896.SPCC965.12-1.

Proteomic databases

MaxQBi O59832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC965.12.1 ; SPCC965.12.1:pep ; SPCC965.12 .
GeneIDi 2539107.
KEGGi spo:SPCC965.12.

Organism-specific databases

PomBasei SPCC965.12.

Phylogenomic databases

eggNOGi COG2355.
HOGENOMi HOG000072016.
InParanoidi O59832.
KOi K01273.
OMAi RNDINGQ.
OrthoDBi EOG7XM371.
PhylomeDBi O59832.

Enzyme and pathway databases

Reactomei REACT_193583. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Miscellaneous databases

NextBioi 20800279.

Family and domain databases

InterProi IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiDPEH2_SCHPO
AccessioniPrimary (citable) accession number: O59832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3