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O59832

- DPEH2_SCHPO

UniProt

O59832 - DPEH2_SCHPO

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Protein
Uncharacterized dipeptidase C965.12
Gene
SPCC965.12
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of dipeptides.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Zinc 1; catalytic By similarity
Metal bindingi31 – 311Zinc 1; catalytic By similarity
Metal bindingi144 – 1441Zinc 1; catalytic By similarity
Metal bindingi144 – 1441Zinc 2; catalytic By similarity
Metal bindingi215 – 2151Zinc 2; catalytic By similarity
Metal bindingi236 – 2361Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. dipeptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_193583. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized dipeptidase C965.12 (EC:3.4.13.19)
    Gene namesi
    ORF Names:SPCC965.12
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC965.12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Uncharacterized dipeptidase C965.12
    PRO_0000314655Add
    BLAST

    Proteomic databases

    MaxQBiO59832.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4676557.
    STRINGi4896.SPCC965.12-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59832.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.

    Phylogenomic databases

    eggNOGiCOG2355.
    HOGENOMiHOG000072016.
    KOiK01273.
    OMAiRNDINGQ.
    OrthoDBiEOG7XM371.
    PhylomeDBiO59832.

    Family and domain databases

    InterProiIPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59832-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVDLREEKE LAQQRFKEIC KHAKIVDTHN DFPYLLRVQL RNKLQLAEFD    50
    FENGLTSHTD LVKMRQGQVG VQFFSCFIEC KNPNYLYQDF DTPTTVVRDT 100
    LEQIDVTRRL VCKYNNDLKF VDCADDAIAA FRNNGKIAIA LGVEGLHQVD 150
    TSLAVLRQYY SLGVRYITLT HNCDNPFATA ASSITGGLPD RGLSAYGIEC 200
    IFEMNRLGMM VDLSHVSHRT MHDALDVTKA PVIFSHSSAY TLTEHERNVR 250
    DDVLERLKTN GGVVQVNFYQ DFIRKPGSDR ATIDDAADHI LHIIKVAGWE 300
    HVGLGSDFDG IPQGPKGLED VSKYPDLICK IIERTNATNE QIEGLMGLNV 350
    LRVWKKTELV ALQLSKKLEP IESSWSGRKW EFYSYAKEFP ELFPDAYKLN 400
    EKSTVWNYDQ PLNIEK 416
    Length:416
    Mass (Da):47,421
    Last modified:August 1, 1998 - v1
    Checksum:i8EB843F4C662D625
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA19072.1.
    RefSeqiNP_588522.1. NM_001023511.2.

    Genome annotation databases

    EnsemblFungiiSPCC965.12.1; SPCC965.12.1:pep; SPCC965.12.
    GeneIDi2539107.
    KEGGispo:SPCC965.12.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA19072.1 .
    RefSeqi NP_588522.1. NM_001023511.2.

    3D structure databases

    ProteinModelPortali O59832.
    ModBasei Search...

    Protein-protein interaction databases

    MINTi MINT-4676557.
    STRINGi 4896.SPCC965.12-1.

    Proteomic databases

    MaxQBi O59832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC965.12.1 ; SPCC965.12.1:pep ; SPCC965.12 .
    GeneIDi 2539107.
    KEGGi spo:SPCC965.12.

    Organism-specific databases

    PomBasei SPCC965.12.

    Phylogenomic databases

    eggNOGi COG2355.
    HOGENOMi HOG000072016.
    KOi K01273.
    OMAi RNDINGQ.
    OrthoDBi EOG7XM371.
    PhylomeDBi O59832.

    Enzyme and pathway databases

    Reactomei REACT_193583. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Miscellaneous databases

    NextBioi 20800279.

    Family and domain databases

    InterProi IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiDPEH2_SCHPO
    AccessioniPrimary (citable) accession number: O59832
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 1, 1998
    Last modified: September 3, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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