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Protein

Alanine racemase, catabolic

Gene

alr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-alanine = D-alanine.

Cofactori

pH dependencei

Optimum pH is 9.0-9.5.

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase, catabolic (alr1)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineBy similarity1
Active sitei269Proton acceptor; specific for L-alanineBy similarity1

GO - Molecular functioni

  • alanine racemase activity Source: PomBase
  • serine racemase activity Source: PomBase

GO - Biological processi

  • alanine metabolic process Source: PomBase
  • D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi5.1.1.1. 5613.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase, catabolic (EC:5.1.1.1)
Gene namesi
Name:alr1
ORF Names:SPCC965.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC965.08c.
PomBaseiSPCC965.08c. alr1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146041 – 375Alanine racemase, catabolicAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiO59828.

Interactioni

Protein-protein interaction databases

BioGridi275325. 1 interactor.
MINTiMINT-4676515.

Structurei

3D structure databases

ProteinModelPortaliO59828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.Curated

Phylogenomic databases

HOGENOMiHOG000031446.
InParanoidiO59828.
KOiK01775.
OMAiTHAKNQM.
PhylomeDBiO59828.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAKSVIDL HAIAHNYNVA KQMMLQKNPS GHVLAIVKAN AYGHGAVQVA
60 70 80 90 100
RFLLKHCSSI DGFGVSSIEE ALELRHGGIY NKIVLLEGFF TEEDELKLID
110 120 130 140 150
DYNFSIIIHS EDQVNSFIKY PFNRPVEIWL KLDSGMNRLG FTPSQFMKFY
160 170 180 190 200
NLLSNNKNVS NIGKITHFAF ADMLENPEHT LKQWDIFEKS VAHLPGPLSA
210 220 230 240 250
GGSAIILGWL NTVCTDWLRA GIMLYGISPF LSKNKDSKTP ESVNIKPAMK
260 270 280 290 300
LVSTIISVKH VDKGQPIGYG GRYVATRDMK LGVVAMGYGD GFPRQVKDGC
310 320 330 340 350
PVLVNGVKAP IVGRVSMDML TVDLSDIPDV KPGDEVIFWG TPELTVADIA
360 370
KYCSDTSPYE LVTKLTRRVP LQYTY
Length:375
Mass (Da):41,585
Last modified:August 1, 1998 - v1
Checksum:i76CEBD17E159E13F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19068.1.
PIRiT41661.
RefSeqiNP_588518.1. NM_001023507.2.

Genome annotation databases

EnsemblFungiiSPCC965.08c.1; SPCC965.08c.1:pep; SPCC965.08c.
GeneIDi2538742.
KEGGispo:SPCC965.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19068.1.
PIRiT41661.
RefSeqiNP_588518.1. NM_001023507.2.

3D structure databases

ProteinModelPortaliO59828.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275325. 1 interactor.
MINTiMINT-4676515.

Proteomic databases

PRIDEiO59828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC965.08c.1; SPCC965.08c.1:pep; SPCC965.08c.
GeneIDi2538742.
KEGGispo:SPCC965.08c.

Organism-specific databases

EuPathDBiFungiDB:SPCC965.08c.
PomBaseiSPCC965.08c. alr1.

Phylogenomic databases

HOGENOMiHOG000031446.
InParanoidiO59828.
KOiK01775.
OMAiTHAKNQM.
PhylomeDBiO59828.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BRENDAi5.1.1.1. 5613.

Miscellaneous databases

PROiO59828.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALR1_SCHPO
AccessioniPrimary (citable) accession number: O59828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.