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Protein

Glutathione S-transferase 2

Gene

gst2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the oxidative stress response and detoxification.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: PomBase

GO - Biological processi

  1. cellular response to oxidative stress Source: PomBase
  2. metabolic process Source: GOC
  3. response to drug Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 2 (EC:2.5.1.18)
Alternative name(s):
GST-II
Gene namesi
Name:gst2
ORF Names:SPCC965.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC965.07c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Glutathione S-transferase 2PRO_0000185985Add
BLAST

Proteomic databases

MaxQBiO59827.
PaxDbiO59827.

Expressioni

Inductioni

By O-dinitrobenzene.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi276159. 2 interactions.
MINTiMINT-4676496.
STRINGi4896.SPCC965.07c-1.

Structurei

3D structure databases

ProteinModelPortaliO59827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8685GST N-terminalAdd
BLAST
Domaini93 – 230138GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125752.
InParanoidiO59827.
KOiK00799.
OMAiHEIAERP.
OrthoDBiEOG7KWSWX.
PhylomeDBiO59827.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHFTLYSHA GGPNPWKVVL ALKELNLSYE QIFYDFQKGE QKCKEHLALN
60 70 80 90 100
PNGRVPTLVD HKNNDYTIWE SDAILIYLAD KYDTDRKISL SFDDPEYYKL
110 120 130 140 150
IQYLFFQASG QGVIWGQAGW FNFFHHEPVV SAVTRYRNEI KRVLGVLEDI
160 170 180 190 200
LKDRDYLVAN KYTIADLSFI PWNYNLGGLF GEGKFSFKEE VPQLDFEKEF
210 220 230
PKAYAWNQRL LARPAVKATF EELAKAKEQH
Length:230
Mass (Da):26,843
Last modified:August 1, 1998 - v1
Checksum:i5B96437DD51CCB2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395117 Genomic DNA. Translation: AAK77864.1.
CU329672 Genomic DNA. Translation: CAA19067.1.
PIRiT41660.
RefSeqiNP_588517.1. NM_001023506.2.

Genome annotation databases

EnsemblFungiiSPCC965.07c.1; SPCC965.07c.1:pep; SPCC965.07c.
GeneIDi2539601.
KEGGispo:SPCC965.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395117 Genomic DNA. Translation: AAK77864.1.
CU329672 Genomic DNA. Translation: CAA19067.1.
PIRiT41660.
RefSeqiNP_588517.1. NM_001023506.2.

3D structure databases

ProteinModelPortaliO59827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276159. 2 interactions.
MINTiMINT-4676496.
STRINGi4896.SPCC965.07c-1.

Proteomic databases

MaxQBiO59827.
PaxDbiO59827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC965.07c.1; SPCC965.07c.1:pep; SPCC965.07c.
GeneIDi2539601.
KEGGispo:SPCC965.07c.

Organism-specific databases

PomBaseiSPCC965.07c.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125752.
InParanoidiO59827.
KOiK00799.
OMAiHEIAERP.
OrthoDBiEOG7KWSWX.
PhylomeDBiO59827.

Miscellaneous databases

NextBioi20800758.
PROiO59827.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe."
    Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
    Biochim. Biophys. Acta 1574:399-402(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGST2_SCHPO
AccessioniPrimary (citable) accession number: O59827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.