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O59827 (GST2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione S-transferase 2
EC=2.5.1.18
Alternative name(s):
GST-II
Gene names
Name:gst2
ORF Names:SPCC965.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the oxidative stress response and detoxification. Ref.1

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Induction

By O-dinitrobenzene. Ref.1

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcellular response to oxidative stress

Traceable author statement. Source: GeneDB_Spombe

response to drug

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_Spombe

nucleus

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionglutathione transferase activity

Inferred from direct assay. Source: GeneDB_Spombe

protein heterodimerization activity

Inferred from physical interaction. Source: GeneDB_Spombe

protein homodimerization activity

Inferred from physical interaction. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Glutathione S-transferase 2
PRO_0000185985

Regions

Domain2 – 8685GST N-terminal
Domain93 – 230138GST C-terminal

Sequences

Sequence LengthMass (Da)Tools
O59827 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 5B96437DD51CCB2A

FASTA23026,843
        10         20         30         40         50         60 
MAHFTLYSHA GGPNPWKVVL ALKELNLSYE QIFYDFQKGE QKCKEHLALN PNGRVPTLVD 

        70         80         90        100        110        120 
HKNNDYTIWE SDAILIYLAD KYDTDRKISL SFDDPEYYKL IQYLFFQASG QGVIWGQAGW 

       130        140        150        160        170        180 
FNFFHHEPVV SAVTRYRNEI KRVLGVLEDI LKDRDYLVAN KYTIADLSFI PWNYNLGGLF 

       190        200        210        220        230 
GEGKFSFKEE VPQLDFEKEF PKAYAWNQRL LARPAVKATF EELAKAKEQH

« Hide

References

« Hide 'large scale' references
[1]"A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe."
Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
Biochim. Biophys. Acta 1574:399-402(2002) [PubMed: 11997110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF395117 Genomic DNA. Translation: AAK77864.1.
CU329672 Genomic DNA. Translation: CAA19067.1.
PIRT41660.
RefSeqNP_588517.1. NM_001023506.1.

3D structure databases

ProteinModelPortalO59827.
ModBaseSearch...

Protein-protein interaction databases

STRINGO59827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC965.07c.1; SPCC965.07c.1:pep; SPCC965.07c.
GeneID2539601.
GenomeReviewsGene locus gst2 in contig CU329672_GR.
KEGGspo:SPCC965.07c.
NMPDRfig|4896.1.peg.855.

Organism-specific databases

GeneDB_SpombeSPCC965.07c.

Phylogenomic databases

eggNOGfuNOG04827.
GeneTreeEFGT00050000001327.
HOGENOMHBG753188.
OMAACPKRVL.
OrthoDBEOG4BP4MZ.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-000418-MONOMER.

Gene expression databases

ArrayExpressO59827.

Family and domain databases

InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK00799.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. GST_C_like. 1 hit.
SSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST2_SCHPO
AccessionPrimary (citable) accession number: O59827
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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