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O59827 (GST2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 2

EC=2.5.1.18
Alternative name(s):
GST-II
Gene names
Name:gst2
ORF Names:SPCC965.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the oxidative stress response and detoxification. Ref.1

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Induction

By O-dinitrobenzene. Ref.1

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Glutathione S-transferase 2
PRO_0000185985

Regions

Domain2 – 8685GST N-terminal
Domain93 – 230138GST C-terminal

Sequences

Sequence LengthMass (Da)Tools
O59827 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 5B96437DD51CCB2A

FASTA23026,843
        10         20         30         40         50         60 
MAHFTLYSHA GGPNPWKVVL ALKELNLSYE QIFYDFQKGE QKCKEHLALN PNGRVPTLVD 

        70         80         90        100        110        120 
HKNNDYTIWE SDAILIYLAD KYDTDRKISL SFDDPEYYKL IQYLFFQASG QGVIWGQAGW 

       130        140        150        160        170        180 
FNFFHHEPVV SAVTRYRNEI KRVLGVLEDI LKDRDYLVAN KYTIADLSFI PWNYNLGGLF 

       190        200        210        220        230 
GEGKFSFKEE VPQLDFEKEF PKAYAWNQRL LARPAVKATF EELAKAKEQH 

« Hide

References

« Hide 'large scale' references
[1]"A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe."
Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
Biochim. Biophys. Acta 1574:399-402(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF395117 Genomic DNA. Translation: AAK77864.1.
CU329672 Genomic DNA. Translation: CAA19067.1.
PIRT41660.
RefSeqNP_588517.1. NM_001023506.2.

3D structure databases

ProteinModelPortalO59827.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276159. 2 interactions.
MINTMINT-4676496.
STRING4896.SPCC965.07c-1.

Proteomic databases

MaxQBO59827.
PaxDbO59827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC965.07c.1; SPCC965.07c.1:pep; SPCC965.07c.
GeneID2539601.
KEGGspo:SPCC965.07c.

Organism-specific databases

PomBaseSPCC965.07c.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000125752.
KOK00799.
OMALAFVPWH.
OrthoDBEOG7KWSWX.
PhylomeDBO59827.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800758.
PROO59827.

Entry information

Entry nameGST2_SCHPO
AccessionPrimary (citable) accession number: O59827
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names