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O59827

- GST2_SCHPO

UniProt

O59827 - GST2_SCHPO

Protein

Glutathione S-transferase 2

Gene

gst2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Involved in the oxidative stress response and detoxification.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: PomBase

    GO - Biological processi

    1. cellular response to oxidative stress Source: PomBase
    2. metabolic process Source: GOC
    3. response to drug Source: PomBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 2 (EC:2.5.1.18)
    Alternative name(s):
    GST-II
    Gene namesi
    Name:gst2
    ORF Names:SPCC965.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC965.07c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Glutathione S-transferase 2PRO_0000185985Add
    BLAST

    Proteomic databases

    MaxQBiO59827.
    PaxDbiO59827.

    Expressioni

    Inductioni

    By O-dinitrobenzene.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi276159. 2 interactions.
    MINTiMINT-4676496.
    STRINGi4896.SPCC965.07c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59827.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8685GST N-terminalAdd
    BLAST
    Domaini93 – 230138GST C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125752.
    KOiK00799.
    OMAiLAFVPWH.
    OrthoDBiEOG7KWSWX.
    PhylomeDBiO59827.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59827-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHFTLYSHA GGPNPWKVVL ALKELNLSYE QIFYDFQKGE QKCKEHLALN    50
    PNGRVPTLVD HKNNDYTIWE SDAILIYLAD KYDTDRKISL SFDDPEYYKL 100
    IQYLFFQASG QGVIWGQAGW FNFFHHEPVV SAVTRYRNEI KRVLGVLEDI 150
    LKDRDYLVAN KYTIADLSFI PWNYNLGGLF GEGKFSFKEE VPQLDFEKEF 200
    PKAYAWNQRL LARPAVKATF EELAKAKEQH 230
    Length:230
    Mass (Da):26,843
    Last modified:August 1, 1998 - v1
    Checksum:i5B96437DD51CCB2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF395117 Genomic DNA. Translation: AAK77864.1.
    CU329672 Genomic DNA. Translation: CAA19067.1.
    PIRiT41660.
    RefSeqiNP_588517.1. NM_001023506.2.

    Genome annotation databases

    EnsemblFungiiSPCC965.07c.1; SPCC965.07c.1:pep; SPCC965.07c.
    GeneIDi2539601.
    KEGGispo:SPCC965.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF395117 Genomic DNA. Translation: AAK77864.1 .
    CU329672 Genomic DNA. Translation: CAA19067.1 .
    PIRi T41660.
    RefSeqi NP_588517.1. NM_001023506.2.

    3D structure databases

    ProteinModelPortali O59827.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276159. 2 interactions.
    MINTi MINT-4676496.
    STRINGi 4896.SPCC965.07c-1.

    Proteomic databases

    MaxQBi O59827.
    PaxDbi O59827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC965.07c.1 ; SPCC965.07c.1:pep ; SPCC965.07c .
    GeneIDi 2539601.
    KEGGi spo:SPCC965.07c.

    Organism-specific databases

    PomBasei SPCC965.07c.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125752.
    KOi K00799.
    OMAi LAFVPWH.
    OrthoDBi EOG7KWSWX.
    PhylomeDBi O59827.

    Miscellaneous databases

    NextBioi 20800758.
    PROi O59827.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe."
      Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
      Biochim. Biophys. Acta 1574:399-402(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiGST2_SCHPO
    AccessioniPrimary (citable) accession number: O59827
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3