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Protein

Probable UTP--glucose-1-phosphate uridylyltransferase

Gene

SPCC794.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221UTPBy similarity
Binding sitei185 – 1851UTPBy similarity
Binding sitei214 – 2141UTP; via amide nitrogenBy similarity
Binding sitei215 – 2151SubstrateBy similarity
Binding sitei245 – 2451UTPBy similarity
Binding sitei387 – 3871UTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SPO-173599. Formation of the active cofactor, UDP-glucuronate.
R-SPO-3322077. Glycogen synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
ORF Names:SPCC794.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC794.10.
PomBaseiSPCC794.10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Probable UTP--glucose-1-phosphate uridylyltransferasePRO_0000185764Add
BLAST

Proteomic databases

MaxQBiO59819.

Interactioni

Protein-protein interaction databases

BioGridi276144. 1 interaction.
MINTiMINT-4676422.

Structurei

3D structure databases

ProteinModelPortaliO59819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni108 – 1114UTP bindingBy similarity
Regioni110 – 1112Substrate bindingBy similarity
Regioni243 – 2453Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

HOGENOMiHOG000113618.
InParanoidiO59819.
KOiK00963.
OrthoDBiEOG092C1XSD.
PhylomeDBiO59819.

Family and domain databases

CDDicd00897. UGPase_euk. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
IPR016267. UDPGP_trans.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O59819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHRRIHFKS QSTLDFDSVA VSISASTMKN ELDKLVLNSR VSDKKTFGIQ
60 70 80 90 100
MDNFFALYRR YLLHTVKGYE CDWDSIRPLG PEDMIDYGDL PLCKNAGKYL
110 120 130 140 150
NRLAVVKLNG GMGNALGVNY PKAMIEVRDN QSFLDLSIRQ IEYLNRRYDV
160 170 180 190 200
SVPFILMNSY DTNDETCKVL RKYAGCKIDI STFEQSRYPR VFVDSQLPVP
210 220 230 240 250
KAAPSPIEEW YPPGHGDIFD ALVHSGTIER LLAQGKDYLF VSNIDNLGAS
260 270 280 290 300
VDLNILSHVI DNQIEYSMEI TDKTKADIKV GILVNQDGLL RLLETNQVPE
310 320 330 340 350
QHREEFMSDK VFKYINTNNV WLYLPAVKRV VENRELNLDI MPNIETVYYN
360 370 380 390 400
NEPARIIEFT TAIGSAISQF KKTEGIRVSR PRFISVKNSS DLFLVRCDLY
410 420 430 440 450
NVDHGSLKIE ESRLGFPPPV VRMSNEFKDI AELFCRIPYM PSMKDLVSLS
460 470 480 490
ISGNVYFGRN VILKGNIVIV ASENTILCIP SNAVLENCVV TGNCKIMEC
Length:499
Mass (Da):56,740
Last modified:August 1, 1998 - v1
Checksum:i8DE4ABC3EC212A60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19137.1.
AB027910 Genomic DNA. Translation: BAA87214.1.
PIRiT41618.
RefSeqiNP_587758.1. NM_001022751.2.

Genome annotation databases

EnsemblFungiiSPCC794.10.1; SPCC794.10.1:pep; SPCC794.10.
GeneIDi2539585.
KEGGispo:SPCC794.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19137.1.
AB027910 Genomic DNA. Translation: BAA87214.1.
PIRiT41618.
RefSeqiNP_587758.1. NM_001022751.2.

3D structure databases

ProteinModelPortaliO59819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276144. 1 interaction.
MINTiMINT-4676422.

Proteomic databases

MaxQBiO59819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC794.10.1; SPCC794.10.1:pep; SPCC794.10.
GeneIDi2539585.
KEGGispo:SPCC794.10.

Organism-specific databases

EuPathDBiFungiDB:SPCC794.10.
PomBaseiSPCC794.10.

Phylogenomic databases

HOGENOMiHOG000113618.
InParanoidiO59819.
KOiK00963.
OrthoDBiEOG092C1XSD.
PhylomeDBiO59819.

Enzyme and pathway databases

ReactomeiR-SPO-173599. Formation of the active cofactor, UDP-glucuronate.
R-SPO-3322077. Glycogen synthesis.

Miscellaneous databases

PROiO59819.

Family and domain databases

CDDicd00897. UGPase_euk. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
IPR016267. UDPGP_trans.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUGPA2_SCHPO
AccessioniPrimary (citable) accession number: O59819
Secondary accession number(s): Q9UTZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.