O59819 (UGPA2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase

Gene names

ORF Names:

SPCC794.10

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Subcellular location	Cytoplasm. Nucleus Ref.2 Ref.3.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from sequence orthology. Source: PomBase
Cellular_component	cytosol Inferred from direct assay Ref.3. Source: PomBase nucleus Inferred from direct assay Ref.3. Source: PomBase
Molecular_function	nucleotidyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Probable UTP--glucose-1-phosphate uridylyltransferase		PRO_0000185764

Sequences

	Sequence		Length	Mass (Da)
	O59819 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 8DE4ABC3EC212A60	FASTA	499	56,740
	10 20 30 40 50 60 MLHRRIHFKS QSTLDFDSVA VSISASTMKN ELDKLVLNSR VSDKKTFGIQ MDNFFALYRR 70 80 90 100 110 120 YLLHTVKGYE CDWDSIRPLG PEDMIDYGDL PLCKNAGKYL NRLAVVKLNG GMGNALGVNY 130 140 150 160 170 180 PKAMIEVRDN QSFLDLSIRQ IEYLNRRYDV SVPFILMNSY DTNDETCKVL RKYAGCKIDI 190 200 210 220 230 240 STFEQSRYPR VFVDSQLPVP KAAPSPIEEW YPPGHGDIFD ALVHSGTIER LLAQGKDYLF 250 260 270 280 290 300 VSNIDNLGAS VDLNILSHVI DNQIEYSMEI TDKTKADIKV GILVNQDGLL RLLETNQVPE 310 320 330 340 350 360 QHREEFMSDK VFKYINTNNV WLYLPAVKRV VENRELNLDI MPNIETVYYN NEPARIIEFT 370 380 390 400 410 420 TAIGSAISQF KKTEGIRVSR PRFISVKNSS DLFLVRCDLY NVDHGSLKIE ESRLGFPPPV 430 440 450 460 470 480 VRMSNEFKDI AELFCRIPYM PSMKDLVSLS ISGNVYFGRN VILKGNIVIV ASENTILCIP 490 SNAVLENCVV TGNCKIMEC

References

[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library." Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y. Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 44-252, SUBCELLULAR LOCATION. Strain: ATCC 38364 / 968.
[3]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAA19137.1. AB027910 Genomic DNA. Translation: BAA87214.1.
PIR	T41618.
RefSeq	NP_587758.1. NM_001022751.2.
3D structure databases
ProteinModelPortal	O59819.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPCC794.10-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC794.10.1; SPCC794.10.1:pep; SPCC794.10.
GeneID	2539585.
KEGG	spo:SPCC794.10.
Organism-specific databases
PomBase	SPCC794.10.
Phylogenomic databases
HOGENOM	HOG000113618.
KO	K00963.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_subgr. [Graphical view]
PANTHER	PTHR11952. PTHR11952. 1 hit. PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...
Other
NextBio	20800743.

Entry information

Entry name

UGPA2_SCHPO

Accession

Primary (citable) accession number: O59819
Secondary accession number(s): Q9UTZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program