O59819 (UGPA2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase

Gene names

ORF Names:

SPCC794.10

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Probable UTP--glucose-1-phosphate uridylyltransferase		PRO_0000185764

Sequences

	Sequence		Length	Mass (Da)
	O59819 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 8DE4ABC3EC212A60	FASTA	499	56,740
	10 20 30 40 50 60 MLHRRIHFKS QSTLDFDSVA VSISASTMKN ELDKLVLNSR VSDKKTFGIQ MDNFFALYRR 70 80 90 100 110 120 YLLHTVKGYE CDWDSIRPLG PEDMIDYGDL PLCKNAGKYL NRLAVVKLNG GMGNALGVNY 130 140 150 160 170 180 PKAMIEVRDN QSFLDLSIRQ IEYLNRRYDV SVPFILMNSY DTNDETCKVL RKYAGCKIDI 190 200 210 220 230 240 STFEQSRYPR VFVDSQLPVP KAAPSPIEEW YPPGHGDIFD ALVHSGTIER LLAQGKDYLF 250 260 270 280 290 300 VSNIDNLGAS VDLNILSHVI DNQIEYSMEI TDKTKADIKV GILVNQDGLL RLLETNQVPE 310 320 330 340 350 360 QHREEFMSDK VFKYINTNNV WLYLPAVKRV VENRELNLDI MPNIETVYYN NEPARIIEFT 370 380 390 400 410 420 TAIGSAISQF KKTEGIRVSR PRFISVKNSS DLFLVRCDLY NVDHGSLKIE ESRLGFPPPV 430 440 450 460 470 480 VRMSNEFKDI AELFCRIPYM PSMKDLVSLS ISGNVYFGRN VILKGNIVIV ASENTILCIP 490 SNAVLENCVV TGNCKIMEC

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAA19137.1.
PIR	T41618.
RefSeq	NP_587758.1. NM_001022751.1.
3D structure databases
ProteinModelPortal	O59819.
ModBase	Search...
Protein-protein interaction databases
STRING	O59819.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC794.10.1; SPCC794.10.1:pep; SPCC794.10.
GeneID	2539585.
KEGG	spo:SPCC794.10.
NMPDR	fig|4896.1.peg.96.
Organism-specific databases
GeneDB_Spombe	SPCC794.10.
Phylogenomic databases
eggNOG	fuNOG05246.
GeneTree	EFGT00050000004058.
HOGENOM	HBG316482.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-002117-MONOMER.
Gene expression databases
ArrayExpress	O59819.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_subgr. [Graphical view]
KO	K00963.
PANTHER	PTHR11952:SF1. PTHR11952:SF1. 1 hit. PTHR11952. UDPGP_trans. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UGPA2_SCHPO

Accession

Primary (citable) accession number: O59819

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program