ID   G6PD2_SCHPO             Reviewed;         475 AA.
AC   O59812;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Probable glucose-6-phosphate 1-dehydrogenase C794.01c;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   ORFNames=SPCC794.01c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; CU329672; CAA19129.1; -; Genomic_DNA.
DR   PIR; T41610; T41610.
DR   RefSeq; NP_587749.1; -.
DR   HSSP; P11413; 1QKI.
DR   GeneID; 2539576; -.
DR   KEGG; spo:SPCC794.01c; -.
DR   NMPDR; fig|4896.1.peg.87; -.
DR   GeneDB_Spombe; SPCC794.01c; -.
DR   OMA; O59812; ASECTRI.
DR   ArrayExpress; O59812; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
DR   GO; GO:0006010; P:glucose 6-phosphate utilization; IC:GeneDB_SPombe.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IC:GeneDB_SPombe.
DR   InterPro; IPR001282; Glc-6-P_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Glucose metabolism; NADP; Oxidoreductase.
FT   CHAIN         1    475       Probable glucose-6-phosphate 1-
FT                                dehydrogenase C794.01c.
FT                                /FTId=PRO_0000337687.
FT   ACT_SITE    238    238       Proton acceptor (By similarity).
FT   BINDING      10     10       NADP (By similarity).
FT   BINDING      42     42       NADP (By similarity).
FT   BINDING     176    176       Substrate (By similarity).
SQ   SEQUENCE   475 AA;  53510 MW;  C2CBB43BD6E70C45 CRC64;
     MLSIIVFGAS GDLATKMTFP ALFALYVRKI IPEDFQIIGY ARSKLSQEAA NKIVTAHIPI
     DDTVGASQKA LNTFVEHYKY VPGTYDKPES FEMLNSIIAE KETAPASECT RIFYLVLPPH
     LFAPVSELIK SKAHPNGMVT RLIVEKPIGF DYKSADAILS DLSKHWSAKD TFKVDHFLGE
     DMIDGFTAIR FANSMFEPIW NREHIESVRV DFREDFGCEG RGGYFEGAGI LRDVVQNHLL
     QLLTLLCIEE PKSQDAEDII KCKVDFLKSL HPVSKEDIVY GQYTKSANGK VPGYRELDGV
     ADDSEVSTFC ALQLRSEAPR WKGIPIIISA GKGLDRDYFE ARITFKRREG GMFPTVDSSN
     VLVLRVYPKE FIALKGHIKQ PGFSRQIVPV TLDVKYPEAF PDTWIHKAYE VVIADAINGK
     HTHFISDDEV RTSWKIFDDV LDTTGDLSPL PYAFGSHHGP DATLEFFKKR NLEWD
//