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Protein

Probable glucose-6-phosphate 1-dehydrogenase C794.01c

Gene

SPCC794.01c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf1), Probable glucose-6-phosphate 1-dehydrogenase C794.01c (SPCC794.01c), Probable glucose-6-phosphate 1-dehydrogenase C7.13c (SPAC3C7.13c)
  2. Probable 6-phosphogluconolactonase (SPCC16C4.10)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SPBC660.16)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42NADPBy similarity1
Binding sitei146NADP; via carbonyl oxygenBy similarity1
Binding sitei146SubstrateBy similarity1
Binding sitei214SubstrateBy similarity1
Binding sitei233SubstrateBy similarity1
Active sitei238Proton acceptorBy similarity1
Binding sitei332SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate 1-dehydrogenase C794.01c (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
ORF Names:SPCC794.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC794.01c
PomBaseiSPCC794.01c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003376871 – 475Probable glucose-6-phosphate 1-dehydrogenase C794.01cAdd BLAST475

Proteomic databases

MaxQBiO59812
PaxDbiO59812
PRIDEiO59812

Interactioni

Protein-protein interaction databases

BioGridi276136, 25 interactors
STRINGi4896.SPCC794.01c.1

Structurei

3D structure databases

ProteinModelPortaliO59812
SMRiO59812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 180Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000046192
InParanoidiO59812
KOiK00036
OMAiSETHPPV
OrthoDBiEOG092C2MOH
PhylomeDBiO59812

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit

Sequencei

Sequence statusi: Complete.

O59812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIIVFGAS GDLATKMTFP ALFALYVRKI IPEDFQIIGY ARSKLSQEAA
60 70 80 90 100
NKIVTAHIPI DDTVGASQKA LNTFVEHYKY VPGTYDKPES FEMLNSIIAE
110 120 130 140 150
KETAPASECT RIFYLVLPPH LFAPVSELIK SKAHPNGMVT RLIVEKPIGF
160 170 180 190 200
DYKSADAILS DLSKHWSAKD TFKVDHFLGE DMIDGFTAIR FANSMFEPIW
210 220 230 240 250
NREHIESVRV DFREDFGCEG RGGYFEGAGI LRDVVQNHLL QLLTLLCIEE
260 270 280 290 300
PKSQDAEDII KCKVDFLKSL HPVSKEDIVY GQYTKSANGK VPGYRELDGV
310 320 330 340 350
ADDSEVSTFC ALQLRSEAPR WKGIPIIISA GKGLDRDYFE ARITFKRREG
360 370 380 390 400
GMFPTVDSSN VLVLRVYPKE FIALKGHIKQ PGFSRQIVPV TLDVKYPEAF
410 420 430 440 450
PDTWIHKAYE VVIADAINGK HTHFISDDEV RTSWKIFDDV LDTTGDLSPL
460 470
PYAFGSHHGP DATLEFFKKR NLEWD
Length:475
Mass (Da):53,510
Last modified:August 1, 1998 - v1
Checksum:iC2CBB43BD6E70C45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA19129.1
PIRiT41610
RefSeqiNP_587749.1, NM_001022743.2

Genome annotation databases

EnsemblFungiiSPCC794.01c.1; SPCC794.01c.1:pep; SPCC794.01c
KEGGispo:SPCC794.01c

Entry informationi

Entry nameiG6PD2_SCHPO
AccessioniPrimary (citable) accession number: O59812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health