Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O59812

- G6PD2_SCHPO

UniProt

O59812 - G6PD2_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glucose-6-phosphate 1-dehydrogenase C794.01c

Gene

SPCC794.01c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421NADPBy similarity
Binding sitei146 – 1461NADP; via carbonyl oxygenBy similarity
Binding sitei146 – 1461SubstrateBy similarity
Binding sitei214 – 2141SubstrateBy similarity
Binding sitei233 – 2331SubstrateBy similarity
Active sitei238 – 2381Proton acceptorBy similarity
Binding sitei332 – 3321SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158NADPBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: PomBase
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: PomBase
  2. pentose-phosphate shunt, oxidative branch Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate 1-dehydrogenase C794.01c (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
ORF Names:SPCC794.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC794.01c.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Probable glucose-6-phosphate 1-dehydrogenase C794.01cPRO_0000337687Add
BLAST

Proteomic databases

MaxQBiO59812.

Interactioni

Protein-protein interaction databases

BioGridi276136. 25 interactions.
MINTiMINT-4676378.
STRINGi4896.SPCC794.01c-1.

Structurei

3D structure databases

ProteinModelPortaliO59812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1805Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
InParanoidiO59812.
KOiK00036.
OMAiFRFANAF.
OrthoDBiEOG7TXKRP.
PhylomeDBiO59812.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.

Sequencei

Sequence statusi: Complete.

O59812-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSIIVFGAS GDLATKMTFP ALFALYVRKI IPEDFQIIGY ARSKLSQEAA
60 70 80 90 100
NKIVTAHIPI DDTVGASQKA LNTFVEHYKY VPGTYDKPES FEMLNSIIAE
110 120 130 140 150
KETAPASECT RIFYLVLPPH LFAPVSELIK SKAHPNGMVT RLIVEKPIGF
160 170 180 190 200
DYKSADAILS DLSKHWSAKD TFKVDHFLGE DMIDGFTAIR FANSMFEPIW
210 220 230 240 250
NREHIESVRV DFREDFGCEG RGGYFEGAGI LRDVVQNHLL QLLTLLCIEE
260 270 280 290 300
PKSQDAEDII KCKVDFLKSL HPVSKEDIVY GQYTKSANGK VPGYRELDGV
310 320 330 340 350
ADDSEVSTFC ALQLRSEAPR WKGIPIIISA GKGLDRDYFE ARITFKRREG
360 370 380 390 400
GMFPTVDSSN VLVLRVYPKE FIALKGHIKQ PGFSRQIVPV TLDVKYPEAF
410 420 430 440 450
PDTWIHKAYE VVIADAINGK HTHFISDDEV RTSWKIFDDV LDTTGDLSPL
460 470
PYAFGSHHGP DATLEFFKKR NLEWD
Length:475
Mass (Da):53,510
Last modified:August 1, 1998 - v1
Checksum:iC2CBB43BD6E70C45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA19129.1.
PIRiT41610.
RefSeqiNP_587749.1. NM_001022743.2.

Genome annotation databases

EnsemblFungiiSPCC794.01c.1; SPCC794.01c.1:pep; SPCC794.01c.
GeneIDi2539576.
KEGGispo:SPCC794.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA19129.1 .
PIRi T41610.
RefSeqi NP_587749.1. NM_001022743.2.

3D structure databases

ProteinModelPortali O59812.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276136. 25 interactions.
MINTi MINT-4676378.
STRINGi 4896.SPCC794.01c-1.

Proteomic databases

MaxQBi O59812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC794.01c.1 ; SPCC794.01c.1:pep ; SPCC794.01c .
GeneIDi 2539576.
KEGGi spo:SPCC794.01c.

Organism-specific databases

PomBasei SPCC794.01c.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
InParanoidi O59812.
KOi K00036.
OMAi FRFANAF.
OrthoDBi EOG7TXKRP.
PhylomeDBi O59812.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Miscellaneous databases

NextBioi 20800735.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiG6PD2_SCHPO
AccessioniPrimary (citable) accession number: O59812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3