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Protein

Probable glucose-6-phosphate 1-dehydrogenase C794.01c

Gene

SPCC794.01c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway:ipentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf1), Probable glucose-6-phosphate 1-dehydrogenase C794.01c (SPCC794.01c), Probable glucose-6-phosphate 1-dehydrogenase C7.13c (SPAC3C7.13c)
  2. Probable 6-phosphogluconolactonase (SPCC16C4.10)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SPBC660.16)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421NADPBy similarity
Binding sitei146 – 1461NADP; via carbonyl oxygenBy similarity
Binding sitei146 – 1461SubstrateBy similarity
Binding sitei214 – 2141SubstrateBy similarity
Binding sitei233 – 2331SubstrateBy similarity
Active sitei238 – 2381Proton acceptorBy similarity
Binding sitei332 – 3321SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate 1-dehydrogenase C794.01c (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
ORF Names:SPCC794.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC794.01c.
PomBaseiSPCC794.01c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Probable glucose-6-phosphate 1-dehydrogenase C794.01cPRO_0000337687Add
BLAST

Proteomic databases

MaxQBiO59812.

Interactioni

Protein-protein interaction databases

BioGridi276136. 25 interactions.
MINTiMINT-4676378.

Structurei

3D structure databases

ProteinModelPortaliO59812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1805Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
InParanoidiO59812.
KOiK00036.
OMAiASECTRI.
OrthoDBiEOG7TXKRP.
PhylomeDBiO59812.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.

Sequencei

Sequence statusi: Complete.

O59812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIIVFGAS GDLATKMTFP ALFALYVRKI IPEDFQIIGY ARSKLSQEAA
60 70 80 90 100
NKIVTAHIPI DDTVGASQKA LNTFVEHYKY VPGTYDKPES FEMLNSIIAE
110 120 130 140 150
KETAPASECT RIFYLVLPPH LFAPVSELIK SKAHPNGMVT RLIVEKPIGF
160 170 180 190 200
DYKSADAILS DLSKHWSAKD TFKVDHFLGE DMIDGFTAIR FANSMFEPIW
210 220 230 240 250
NREHIESVRV DFREDFGCEG RGGYFEGAGI LRDVVQNHLL QLLTLLCIEE
260 270 280 290 300
PKSQDAEDII KCKVDFLKSL HPVSKEDIVY GQYTKSANGK VPGYRELDGV
310 320 330 340 350
ADDSEVSTFC ALQLRSEAPR WKGIPIIISA GKGLDRDYFE ARITFKRREG
360 370 380 390 400
GMFPTVDSSN VLVLRVYPKE FIALKGHIKQ PGFSRQIVPV TLDVKYPEAF
410 420 430 440 450
PDTWIHKAYE VVIADAINGK HTHFISDDEV RTSWKIFDDV LDTTGDLSPL
460 470
PYAFGSHHGP DATLEFFKKR NLEWD
Length:475
Mass (Da):53,510
Last modified:August 1, 1998 - v1
Checksum:iC2CBB43BD6E70C45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19129.1.
PIRiT41610.
RefSeqiNP_587749.1. NM_001022743.2.

Genome annotation databases

EnsemblFungiiSPCC794.01c.1; SPCC794.01c.1:pep; SPCC794.01c.
GeneIDi2539576.
KEGGispo:SPCC794.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19129.1.
PIRiT41610.
RefSeqiNP_587749.1. NM_001022743.2.

3D structure databases

ProteinModelPortaliO59812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276136. 25 interactions.
MINTiMINT-4676378.

Proteomic databases

MaxQBiO59812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC794.01c.1; SPCC794.01c.1:pep; SPCC794.01c.
GeneIDi2539576.
KEGGispo:SPCC794.01c.

Organism-specific databases

EuPathDBiFungiDB:SPCC794.01c.
PomBaseiSPCC794.01c.

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
InParanoidiO59812.
KOiK00036.
OMAiASECTRI.
OrthoDBiEOG7TXKRP.
PhylomeDBiO59812.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Miscellaneous databases

NextBioi20800735.
PROiO59812.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiG6PD2_SCHPO
AccessioniPrimary (citable) accession number: O59812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.