ID   BADH_SCHPO              Reviewed;         500 AA.
AC   O59808;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 149.
DE   RecName: Full=Probable betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
DE   AltName: Full=Meiotic expression up-regulated protein 8;
GN   Name=meu8; ORFNames=SPCC550.10;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 420-500.
RC   STRAIN=CD16-1;
RX   PubMed=11376151; DOI=10.1093/nar/29.11.2327;
RA   Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y.,
RA   Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.;
RT   "Comprehensive isolation of meiosis-specific genes identifies novel
RT   proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.";
RL   Nucleic Acids Res. 29:2327-2337(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15710, ChEBI:CHEBI:17750, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.8;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CU329672; CAA19114.1; -; Genomic_DNA.
DR   EMBL; AB054529; BAB60885.2; -; mRNA.
DR   PIR; T41385; T41385.
DR   RefSeq; NP_588102.1; NM_001023093.2.
DR   AlphaFoldDB; O59808; -.
DR   SMR; O59808; -.
DR   BioGRID; 275834; 7.
DR   STRING; 284812.O59808; -.
DR   PaxDb; 4896-SPCC550-10-1; -.
DR   EnsemblFungi; SPCC550.10.1; SPCC550.10.1:pep; SPCC550.10.
DR   GeneID; 2539264; -.
DR   KEGG; spo:SPCC550.10; -.
DR   PomBase; SPCC550.10; -.
DR   VEuPathDB; FungiDB:SPCC550.10; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_2_1; -.
DR   InParanoid; O59808; -.
DR   OMA; GDHTSYV; -.
DR   PhylomeDB; O59808; -.
DR   UniPathway; UPA00529; UER00386.
DR   PRO; PR:O59808; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070458; P:cellular detoxification of nitrogen compound; IC:PomBase.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd07078; ALDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR43860; BETAINE ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43860:SF2; BETAINE ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Meiosis; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..500
FT                   /note="Probable betaine aldehyde dehydrogenase"
FT                   /id="PRO_0000056531"
FT   ACT_SITE        271
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007,
FT                   ECO:0000255|PROSITE-ProRule:PRU10008"
FT   ACT_SITE        305
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007,
FT                   ECO:0000255|PROSITE-ProRule:PRU10008"
FT   BINDING         249..254
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   SITE            173
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   500 AA;  54144 MW;  BFFF9D7C1A11ACA0 CRC64;
     MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI IGTCANASAK
     DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK RELLAGIDTI NCGKPTPYAL
     FDIDSCADMF EYYAEVAETD NPTVKVPLPN NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL
     WKLVPAIASG NCVVLKPSEL APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP
     KIAYLAFTGS LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN
     QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK TQFEKIVSYI
     QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW REEIFGPVLA VKTFHTNEEA
     LELANDSEYG LGSGVFSTNP KTLEFFSNNI EAGMCSLNNY HVVTHELPWI GWKHSGLGVG
     LSKHGYNEYM RLKQITQYVG
//