ID   BADH_SCHPO              Reviewed;         500 AA.
AC   O59808;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 60.
DE   RecName: Full=Probable betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
DE   AltName: Full=Meiotic expression up-regulated protein 8;
GN   Name=meu8; ORFNames=SPCC550.10;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 420-500.
RC   STRAIN=CD16-1;
RX   MEDLINE=21270454; PubMed=11376151; DOI=10.1093/nar/29.11.2327;
RA   Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y.,
RA   Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.;
RT   "Comprehensive isolation of meiosis-specific genes identifies novel
RT   proteins and unusual non-coding transcripts in Schizosaccharomyces
RT   pombe.";
RL   Nucleic Acids Res. 29:2327-2337(2001).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CU329672; CAA19114.1; -; Genomic_DNA.
DR   EMBL; AB054529; BAB60885.2; -; mRNA.
DR   PIR; T41385; T41385.
DR   RefSeq; NP_588102.1; -.
DR   HSSP; P51977; 1BXS.
DR   GeneID; 2539264; -.
DR   KEGG; spo:SPCC550.10; -.
DR   NMPDR; fig|4896.1.peg.440; -.
DR   GeneDB_Spombe; SPCC550.10; -.
DR   OMA; O59808; CANASAK.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000048-MON; -.
DR   BRENDA; 1.2.1.8; 653.
DR   ArrayExpress; O59808; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_SPombe.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC.
DR   GO; GO:0033554; P:cellular response to stress; IEP:GeneDB_SPombe.
DR   GO; GO:0007126; P:meiosis; IEP:GeneDB_SPombe.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Meiosis; NAD; Oxidoreductase.
FT   CHAIN         1    500       Probable betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056531.
FT   NP_BIND     249    254       NAD (By similarity).
FT   ACT_SITE    271    271       Proton acceptor (By similarity).
FT   ACT_SITE    305    305       Nucleophile (By similarity).
FT   SITE        173    173       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   500 AA;  54144 MW;  BFFF9D7C1A11ACA0 CRC64;
     MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI IGTCANASAK
     DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK RELLAGIDTI NCGKPTPYAL
     FDIDSCADMF EYYAEVAETD NPTVKVPLPN NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL
     WKLVPAIASG NCVVLKPSEL APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP
     KIAYLAFTGS LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN
     QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK TQFEKIVSYI
     QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW REEIFGPVLA VKTFHTNEEA
     LELANDSEYG LGSGVFSTNP KTLEFFSNNI EAGMCSLNNY HVVTHELPWI GWKHSGLGVG
     LSKHGYNEYM RLKQITQYVG
//