Reviewed, UniProtKB/Swiss-Prot O59808 (BADH_SCHPO)

Names and origin

Protein names

Recommended name:
    Probable betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8
Alternative name(s):
    Meiotic expression up-regulated protein 8

Gene names

Name:	meu8
ORF Names:	SPCC550.10

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Meiosis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular response to stress Inferred from expression pattern. Source: GeneDB_SPombe meiosis Ref.2 Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Probable betaine aldehyde dehydrogenase		PRO_0000056531
Regions
	Nucleotide binding	249 – 254	6	NAD By similarity
Sites
	Active site	271	1	Proton acceptor By similarity
	Active site	305	1	Nucleophile By similarity
	Site	173	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	O59808-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: BFFF9D7C1A11ACA0	FASTA	500	54,144
	10 20 30 40 50 60 MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI IGTCANASAK 70 80 90 100 110 120 DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK RELLAGIDTI NCGKPTPYAL 130 140 150 160 170 180 FDIDSCADMF EYYAEVAETD NPTVKVPLPN NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL 190 200 210 220 230 240 WKLVPAIASG NCVVLKPSEL APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP 250 260 270 280 290 300 KIAYLAFTGS LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN 310 320 330 340 350 360 QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK TQFEKIVSYI 370 380 390 400 410 420 QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW REEIFGPVLA VKTFHTNEEA 430 440 450 460 470 480 LELANDSEYG LGSGVFSTNP KTLEFFSNNI EAGMCSLNNY HVVTHELPWI GWKHSGLGVG 490 500 LSKHGYNEYM RLKQITQYVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe." Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H. Nucleic Acids Res. 29:2327-2337(2001) [PubMed: 11376151] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 420-500. Strain: CD16-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329672 Genomic DNA. Translation: CAA19114.1. AB054529 mRNA. Translation: BAB60885.2.
PIR	T41385.
RefSeq	NP_588102.1.
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Genome annotation databases
GeneID	2539264.
KEGG	spo:SPCC550.10.
NMPDR	fig|4896.1.peg.440.
Organism-specific databases
GeneDB_Spombe	SPCC550.10.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000048-MON.
Gene expression databases
ArrayExpress	O59808.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH_SCHPO

Accession

Primary (citable) accession number: O59808

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	August 1, 1998
Last modified:	November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)