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Protein

Probable betaine aldehyde dehydrogenase

Gene

meu8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei173 – 1731Transition state stabilizerBy similarity
Active sitei271 – 2711Proton acceptorPROSITE-ProRule annotation
Active sitei305 – 3051NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi249 – 2546NADBy similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: GO_Central

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
  2. meiotic cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Meiosis

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_202243. Carnitine synthesis.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Meiotic expression up-regulated protein 8
Gene namesi
Name:meu8
ORF Names:SPCC550.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC550.10.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Probable betaine aldehyde dehydrogenasePRO_0000056531Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi275834. 4 interactions.
MINTiMINT-4676338.
STRINGi4896.SPCC550.10-1.

Structurei

3D structure databases

ProteinModelPortaliO59808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiO59808.
KOiK00130.
OMAiAYCEQKS.
OrthoDBiEOG7S226Z.
PhylomeDBiO59808.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI
60 70 80 90 100
IGTCANASAK DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK
110 120 130 140 150
RELLAGIDTI NCGKPTPYAL FDIDSCADMF EYYAEVAETD NPTVKVPLPN
160 170 180 190 200
NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL WKLVPAIASG NCVVLKPSEL
210 220 230 240 250
APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP KIAYLAFTGS
260 270 280 290 300
LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN
310 320 330 340 350
QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK
360 370 380 390 400
TQFEKIVSYI QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW
410 420 430 440 450
REEIFGPVLA VKTFHTNEEA LELANDSEYG LGSGVFSTNP KTLEFFSNNI
460 470 480 490 500
EAGMCSLNNY HVVTHELPWI GWKHSGLGVG LSKHGYNEYM RLKQITQYVG
Length:500
Mass (Da):54,144
Last modified:August 1, 1998 - v1
Checksum:iBFFF9D7C1A11ACA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19114.1.
AB054529 mRNA. Translation: BAB60885.2.
PIRiT41385.
RefSeqiNP_588102.1. NM_001023093.2.

Genome annotation databases

EnsemblFungiiSPCC550.10.1; SPCC550.10.1:pep; SPCC550.10.
GeneIDi2539264.
KEGGispo:SPCC550.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19114.1.
AB054529 mRNA. Translation: BAB60885.2.
PIRiT41385.
RefSeqiNP_588102.1. NM_001023093.2.

3D structure databases

ProteinModelPortaliO59808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275834. 4 interactions.
MINTiMINT-4676338.
STRINGi4896.SPCC550.10-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC550.10.1; SPCC550.10.1:pep; SPCC550.10.
GeneIDi2539264.
KEGGispo:SPCC550.10.

Organism-specific databases

PomBaseiSPCC550.10.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiO59808.
KOiK00130.
OMAiAYCEQKS.
OrthoDBiEOG7S226Z.
PhylomeDBiO59808.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.
ReactomeiREACT_202243. Carnitine synthesis.

Miscellaneous databases

NextBioi20800434.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe."
    Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.
    Nucleic Acids Res. 29:2327-2337(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 420-500.
    Strain: CD16-1.

Entry informationi

Entry nameiBADH_SCHPO
AccessioniPrimary (citable) accession number: O59808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: August 1, 1998
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.