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O59808

- BADH_SCHPO

UniProt

O59808 - BADH_SCHPO

Protein

Probable betaine aldehyde dehydrogenase

Gene

meu8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei173 – 1731Transition state stabilizerBy similarity
    Active sitei271 – 2711Proton acceptorPROSITE-ProRule annotation
    Active sitei305 – 3051NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi249 – 2546NADBy similarity

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
    2. meiotic cell cycle Source: PomBase
    3. meiotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_202243. Carnitine synthesis.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable betaine aldehyde dehydrogenase (EC:1.2.1.8)
    Short name:
    BADH
    Alternative name(s):
    Meiotic expression up-regulated protein 8
    Gene namesi
    Name:meu8
    ORF Names:SPCC550.10
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC550.10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Probable betaine aldehyde dehydrogenasePRO_0000056531Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi275834. 4 interactions.
    MINTiMINT-4676338.
    STRINGi4896.SPCC550.10-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59808.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiPFGGNRK.
    OrthoDBiEOG7S226Z.
    PhylomeDBiO59808.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59808-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI    50
    IGTCANASAK DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK 100
    RELLAGIDTI NCGKPTPYAL FDIDSCADMF EYYAEVAETD NPTVKVPLPN 150
    NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL WKLVPAIASG NCVVLKPSEL 200
    APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP KIAYLAFTGS 250
    LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN 300
    QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK 350
    TQFEKIVSYI QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW 400
    REEIFGPVLA VKTFHTNEEA LELANDSEYG LGSGVFSTNP KTLEFFSNNI 450
    EAGMCSLNNY HVVTHELPWI GWKHSGLGVG LSKHGYNEYM RLKQITQYVG 500
    Length:500
    Mass (Da):54,144
    Last modified:August 1, 1998 - v1
    Checksum:iBFFF9D7C1A11ACA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA19114.1.
    AB054529 mRNA. Translation: BAB60885.2.
    PIRiT41385.
    RefSeqiNP_588102.1. NM_001023093.2.

    Genome annotation databases

    EnsemblFungiiSPCC550.10.1; SPCC550.10.1:pep; SPCC550.10.
    GeneIDi2539264.
    KEGGispo:SPCC550.10.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA19114.1 .
    AB054529 mRNA. Translation: BAB60885.2 .
    PIRi T41385.
    RefSeqi NP_588102.1. NM_001023093.2.

    3D structure databases

    ProteinModelPortali O59808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275834. 4 interactions.
    MINTi MINT-4676338.
    STRINGi 4896.SPCC550.10-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC550.10.1 ; SPCC550.10.1:pep ; SPCC550.10 .
    GeneIDi 2539264.
    KEGGi spo:SPCC550.10.

    Organism-specific databases

    PomBasei SPCC550.10.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi PFGGNRK.
    OrthoDBi EOG7S226Z.
    PhylomeDBi O59808.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    Reactomei REACT_202243. Carnitine synthesis.

    Miscellaneous databases

    NextBioi 20800434.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe."
      Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.
      Nucleic Acids Res. 29:2327-2337(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 420-500.
      Strain: CD16-1.

    Entry informationi

    Entry nameiBADH_SCHPO
    AccessioniPrimary (citable) accession number: O59808
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3