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O59808

- BADH_SCHPO

UniProt

O59808 - BADH_SCHPO

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Protein

Probable betaine aldehyde dehydrogenase

Gene
meu8, SPCC550.10
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei173 – 1731Transition state stabilizer By similarity
Active sitei271 – 2711Proton acceptor By similarity
Active sitei305 – 3051Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi249 – 2546NAD By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
  2. meiotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Meiosis

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_202243. Carnitine synthesis.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Meiotic expression up-regulated protein 8
Gene namesi
Name:meu8
ORF Names:SPCC550.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC550.10.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Probable betaine aldehyde dehydrogenasePRO_0000056531Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi275834. 4 interactions.
MINTiMINT-4676338.
STRINGi4896.SPCC550.10-1.

Structurei

3D structure databases

ProteinModelPortaliO59808.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiPFGGNRK.
OrthoDBiEOG7S226Z.
PhylomeDBiO59808.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59808-1 [UniParc]FASTAAdd to Basket

« Hide

MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI    50
IGTCANASAK DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK 100
RELLAGIDTI NCGKPTPYAL FDIDSCADMF EYYAEVAETD NPTVKVPLPN 150
NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL WKLVPAIASG NCVVLKPSEL 200
APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP KIAYLAFTGS 250
LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN 300
QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK 350
TQFEKIVSYI QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW 400
REEIFGPVLA VKTFHTNEEA LELANDSEYG LGSGVFSTNP KTLEFFSNNI 450
EAGMCSLNNY HVVTHELPWI GWKHSGLGVG LSKHGYNEYM RLKQITQYVG 500
Length:500
Mass (Da):54,144
Last modified:August 1, 1998 - v1
Checksum:iBFFF9D7C1A11ACA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA19114.1.
AB054529 mRNA. Translation: BAB60885.2.
PIRiT41385.
RefSeqiNP_588102.1. NM_001023093.2.

Genome annotation databases

EnsemblFungiiSPCC550.10.1; SPCC550.10.1:pep; SPCC550.10.
GeneIDi2539264.
KEGGispo:SPCC550.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA19114.1 .
AB054529 mRNA. Translation: BAB60885.2 .
PIRi T41385.
RefSeqi NP_588102.1. NM_001023093.2.

3D structure databases

ProteinModelPortali O59808.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275834. 4 interactions.
MINTi MINT-4676338.
STRINGi 4896.SPCC550.10-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC550.10.1 ; SPCC550.10.1:pep ; SPCC550.10 .
GeneIDi 2539264.
KEGGi spo:SPCC550.10.

Organism-specific databases

PomBasei SPCC550.10.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi PFGGNRK.
OrthoDBi EOG7S226Z.
PhylomeDBi O59808.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
Reactomei REACT_202243. Carnitine synthesis.

Miscellaneous databases

NextBioi 20800434.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe."
    Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.
    Nucleic Acids Res. 29:2327-2337(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 420-500.
    Strain: CD16-1.

Entry informationi

Entry nameiBADH_SCHPO
AccessioniPrimary (citable) accession number: O59808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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