Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative ATP-dependent RNA helicase C550.03c

Gene

SPCC550.03c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi302 – 3098ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase C550.03c (EC:3.6.4.-)
Gene namesi
ORF Names:SPCC550.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC550.03c.
PomBaseiSPCC550.03c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleolus Source: PomBase
  • Ski complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12131213Putative ATP-dependent RNA helicase C550.03cPRO_0000310785Add
BLAST

Proteomic databases

MaxQBiO59801.

Interactioni

Subunit structurei

Component of the SKI complex.By similarity

Protein-protein interaction databases

BioGridi275422. 62 interactions.
MINTiMINT-4676283.

Structurei

3D structure databases

ProteinModelPortaliO59801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini289 – 445157Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini545 – 736192Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi393 – 3964DEAH box

Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000163048.
InParanoidiO59801.
KOiK12599.
OMAiKMDPWSL.
OrthoDBiEOG7WT48P.
PhylomeDBiO59801.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR025696. rRNA_proc-arch_dom.
IPR016438. Ski2.
IPR012961. Ski2_C.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF08148. DSHCT. 1 hit.
PF00271. Helicase_C. 1 hit.
PF13234. rRNA_proc-arch. 1 hit.
[Graphical view]
PIRSFiPIRSF005198. Antiviral_helicase_SKI2. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM01142. DSHCT. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKLVDAIN EVAVSNKDKI ELDGIKDDSF DGHLSITEAT YDVDTFLKPS
60 70 80 90 100
PALSKDWIRK LQKKWDREIT YKGLYEYPET LARTQIRFQR HGLEGKIMGY
110 120 130 140 150
KEVPELIEDL NSKNSSSFLR KPSSKNEFVR GSTSNIPFLA DDSDVDAIAG
160 170 180 190 200
EPSVKMALYG EDGLLQVPPG FSRGLSMTAT STTDNLNDEF DPEKWDTKKV
210 220 230 240 250
KSSNRNFVTI HELNEHLKNV NSKHSEIDDL LPDKRSIVSL PPSTLNLHKQ
260 270 280 290 300
PDYAHVVDSS APIENFQQLV PEMALDFPFE LDNFQKEAIY HLEMGDSVFV
310 320 330 340 350
AAHTSAGKTV VAEYAIALAQ KHMTKAIYTS PIKALSNQKF RDFKHKFEDV
360 370 380 390 400
GILTGDVQVN PEGSCLLMTT EILRSMLYRG ADLIRDVEFV IFDEVHYVND
410 420 430 440 450
LERGVVWEEV IIMLPPHVTL ILLSATVPNT KEFASWVGRT KKKNIYVIST
460 470 480 490 500
LKRPVPLEHY LWVKQNMFKI VDQHGRFLMD GYKSANDALK KPDKPVIAKD
510 520 530 540 550
NKNSARGRGA ARGRGVQTNM MRGRGSAKSV ERRDANTWVH LIGHLHKQNL
560 570 580 590 600
LPVIVFVFSK KRCEEYVDTL TNRDLNNHQE KSEVHVVIEK AVARLKKEDR
610 620 630 640 650
LLPQIGRMRE MLSRGLAVHH GGLLPIIKEI VEILFQRGLV KVLFATETFA
660 670 680 690 700
MGVNMPAKSV VFSGTQKHDG RNFRDLLPGE YTQCSGRAGR RGLDVTGTVI
710 720 730 740 750
ILSRSELPDT ASLRHMIMGP SSKLISQFRL TYNMILNLLR VETLRIEDMI
760 770 780 790 800
KRSFSENVNQ TLVPQHEEKI KSFEEKLSAL KKEMSDVDLK EIKSCLLSSE
810 820 830 840 850
SFKEYTKKMH FRAITTANGK RIFKDGRVIV FQQLDFTRTV GVLLGTSIRT
860 870 880 890 900
NASDCTLEVA YLNPQNNLKR PSDLLAFADA FNDVYDNAIF DESNQFKYGL
910 920 930 940 950
INLSGIERVC NTILRIDSGG IRDRRGGAFR KLSEQFASIK KFSDLLFEEV
960 970 980 990 1000
NWSKVRDFEF CEAFEKRNFL QNKLSGNPII STPNFLTHFA LAYQEYELES
1010 1020 1030 1040 1050
NIDNLSSYIS DQNLELLPDY EQRIKVLQEL GYIDAERTVL LKGRVACEIN
1060 1070 1080 1090 1100
STSELVLTEL ILENSLADFS CEETIALLSA FVFDEKTEVE PTISPHLQKG
1110 1120 1130 1140 1150
KEMILSVAEK VNQIQEHYQV LYFNEGNDFE SQPRFGLMEV CYEWARGMSF
1160 1170 1180 1190 1200
NRITDLTDVL EGSIVRTIIR LDEVLRECRG AARVVGDSSM YTKMEECQNL
1210
IRRNIVFCPS LYM
Length:1,213
Mass (Da):138,028
Last modified:August 1, 1998 - v1
Checksum:i2F9BE2ABF8068A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19107.1.
PIRiT41378.
RefSeqiNP_588095.1. NM_001023086.2.

Genome annotation databases

EnsemblFungiiSPCC550.03c.1; SPCC550.03c.1:pep; SPCC550.03c.
GeneIDi2538841.
KEGGispo:SPCC550.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19107.1.
PIRiT41378.
RefSeqiNP_588095.1. NM_001023086.2.

3D structure databases

ProteinModelPortaliO59801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275422. 62 interactions.
MINTiMINT-4676283.

Proteomic databases

MaxQBiO59801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC550.03c.1; SPCC550.03c.1:pep; SPCC550.03c.
GeneIDi2538841.
KEGGispo:SPCC550.03c.

Organism-specific databases

EuPathDBiFungiDB:SPCC550.03c.
PomBaseiSPCC550.03c.

Phylogenomic databases

HOGENOMiHOG000163048.
InParanoidiO59801.
KOiK12599.
OMAiKMDPWSL.
OrthoDBiEOG7WT48P.
PhylomeDBiO59801.

Miscellaneous databases

NextBioi20800023.
PROiO59801.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR025696. rRNA_proc-arch_dom.
IPR016438. Ski2.
IPR012961. Ski2_C.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF08148. DSHCT. 1 hit.
PF00271. Helicase_C. 1 hit.
PF13234. rRNA_proc-arch. 1 hit.
[Graphical view]
PIRSFiPIRSF005198. Antiviral_helicase_SKI2. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM01142. DSHCT. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSKI2_SCHPO
AccessioniPrimary (citable) accession number: O59801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.