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Protein

Mitochondrial Rho GTPase 1

Gene

gem1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTP 1Sequence analysis8
Nucleotide bindingi57 – 61GTP 1Sequence analysis5
Nucleotide bindingi113 – 116GTP 1Sequence analysis4
Calcium bindingi197 – 2081PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi317 – 3282PROSITE-ProRule annotationAdd BLAST12
Nucleotide bindingi428 – 435GTP 2Sequence analysis8
Nucleotide bindingi459 – 463GTP 2Sequence analysis5
Nucleotide bindingi527 – 530GTP 2Sequence analysis4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
Gene namesi
Name:gem1
ORF Names:SPCC320.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC320.04c.
PomBaseiSPCC320.04c. gem1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 598Mitochondrial intermembraneSequence analysisAdd BLAST598
Transmembranei599 – 619Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini620 – 630CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • cytosol Source: PomBase
  • ERMES complex Source: PomBase
  • integral component of mitochondrial outer membrane Source: InterPro
  • nuclear envelope Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393391 – 630Mitochondrial Rho GTPase 1Add BLAST630

Proteomic databases

MaxQBiO59781.
PRIDEiO59781.

Interactioni

Protein-protein interaction databases

BioGridi275487. 1 interactor.
MINTiMINT-4676138.

Structurei

3D structure databases

ProteinModelPortaliO59781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 155Miro 1Add BLAST155
Domaini184 – 219EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini304 – 339EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini415 – 561Miro 2Add BLAST147

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 Miro domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000215553.
InParanoidiO59781.
KOiK07870.
OMAiYERIALY.
OrthoDBiEOG092C13Q5.
PhylomeDBiO59781.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEVRVVICG DQGVGKSSLI SALIQEDNVT SIPKVFPIIS IPSNPDSNDD
60 70 80 90 100
VSLVLVDTQS DSNEREYLAA EIKKANVICL VYSDNYSYER VSIFWLPYFR
110 120 130 140 150
SLGVNVPIVL CENKSEDLDN YQGLHTIEHE MIPLINEFKE IEACILCSAL
160 170 180 190 200
EKINVNELFY MCRACVIYPI TPLWDAKERT MRKATIHALS RIFFLIDKNN
210 220 230 240 250
DDLLSVDELN SLSEKCFSKN LSIEDASEIL SKVKEICPEG VYEGQLTLPG
260 270 280 290 300
FLAYNRVQVE NGKQESTWGI LRAFHYTDSL SLDDSYLSPK FEVAPGQIVE
310 320 330 340 350
LSPKGYRFLV DLFYQFDRDN DGALNNEELS ALFRHTPGLP EIWVSSQFPN
360 370 380 390 400
STVLNEHGYV TYNGWLAQWS MITLFDYKTT LAYLAYLGFD TDGRGHNTDA
410 420 430 440 450
LKVMRKRVSQ NRKVSKYDRN VFLCFVVGSK SCGKTALLSS FINNNTNRLT
460 470 480 490 500
PNTVVNSVEF QSTQRYLVLS EIGETDLDIL AEPKSLEACD ILCLLYDSSN
510 520 530 540 550
PNSFSFIANL LNLYPDLQKI PCVFAATKAD LDRQQQRYPV QPDEFTKQLG
560 570 580 590 600
LPSPTHISTA AIWNTSKEFF IQLAESAQYP ASSIIRIPEE DSNKTNYQLV
610 620 630
AALTAFGALL LSVGGSLTWK IIKHQYYSKK
Length:630
Mass (Da):71,177
Last modified:August 1, 1998 - v1
Checksum:i9B36A65260CA3919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18306.1.
PIRiT41307.
RefSeqiNP_587725.1. NM_001022720.2.

Genome annotation databases

EnsemblFungiiSPCC320.04c.1; SPCC320.04c.1:pep; SPCC320.04c.
GeneIDi2538910.
KEGGispo:SPCC320.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18306.1.
PIRiT41307.
RefSeqiNP_587725.1. NM_001022720.2.

3D structure databases

ProteinModelPortaliO59781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275487. 1 interactor.
MINTiMINT-4676138.

Proteomic databases

MaxQBiO59781.
PRIDEiO59781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC320.04c.1; SPCC320.04c.1:pep; SPCC320.04c.
GeneIDi2538910.
KEGGispo:SPCC320.04c.

Organism-specific databases

EuPathDBiFungiDB:SPCC320.04c.
PomBaseiSPCC320.04c. gem1.

Phylogenomic databases

HOGENOMiHOG000215553.
InParanoidiO59781.
KOiK07870.
OMAiYERIALY.
OrthoDBiEOG092C13Q5.
PhylomeDBiO59781.

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.

Miscellaneous databases

PROiO59781.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGEM1_SCHPO
AccessioniPrimary (citable) accession number: O59781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.