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Protein

Aspartic proteinase yapsin-1

Gene

yps1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves at paired basic residues.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85By similarity1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.056

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-1 (EC:3.4.23.-)
Gene namesi
Name:yps1
ORF Names:SPCC1795.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1795.09
PomBaseiSPCC1795.09 yps1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 500ExtracellularSequence analysisAdd BLAST483
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell wall, Endoplasmic reticulum, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000025559818 – 521Aspartic proteinase yapsin-1Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO59774
PRIDEiO59774

Interactioni

Protein-protein interaction databases

BioGridi275503, 16 interactors
STRINGi4896.SPCC1795.09.1

Structurei

3D structure databases

ProteinModelPortaliO59774
SMRiO59774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 409Peptidase A1PROSITE-ProRule annotationAdd BLAST343

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi471 – 474Poly-Ser4

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO59774
OMAiRIWILIF
OrthoDBiEOG092C2HTB
PhylomeDBiO59774

Family and domain databases

Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O59774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIWILIFFS FIKLVSSLQY TGNGVLALDF VAKTFPNQEN QLEKRDYTYS
60 70 80 90 100
PSGITSFPLD LQSYTYYTTT LSIGRPSISY TVAIDLDMPY TWLTYYNVMA
110 120 130 140 150
FNPAYLGIVN SGTQWSTDEL RYFLCKKESD SCYFGNASSS FHFVTSPSTF
160 170 180 190 200
FIRYDDNITV AGINVQDSLS YSHYQALPDF QFGITLKEYV PSSMLPYKGV
210 220 230 240 250
LGLAASTEIN SIDYSDSISS FSPPTFLEQL VKEDILAYPA FSMYLDNQGN
260 270 280 290 300
GSLLLGAVDT SKYQGQFVAL KQTKLTHYAV SIYSVQFLNS TFFSNYSIIT
310 320 330 340 350
DAYFQTRETY IYLPAELAYS VMDNAGAYLS EGYFALNCDE IDLEAALIFQ
360 370 380 390 400
FGCNSTIKVP ISLLVIGQVS NICLLGIRPS TDSEIVLGLL FFRNAYTFYH
410 420 430 440 450
QSQKMIAIGQ AFYNATSNLS AIVDQHIPGA LTCSQYPTSV ASTQLVQTSH
460 470 480 490 500
FTSTSLSAVN ISESVVYSYT SSSSMPSSAI PSFNISLISQ NAVANAGNSF
510 520
SPLSAMVIMM MSAVFLGLGI I
Length:521
Mass (Da):57,623
Last modified:August 1, 1998 - v1
Checksum:i21F002CF829175EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA18644.1
PIRiT41134
RefSeqiNP_588035.1, NM_001023027.2

Genome annotation databases

EnsemblFungiiSPCC1795.09.1; SPCC1795.09.1:pep; SPCC1795.09
GeneIDi2538927
KEGGispo:SPCC1795.09

Similar proteinsi

Entry informationi

Entry nameiYPS1_SCHPO
AccessioniPrimary (citable) accession number: O59774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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