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Protein

Aspartic proteinase yapsin-1

Gene

yps1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Cleaves at paired basic residues.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85By similarity1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: PomBase

GO - Biological processi

  • dibasic protein processing Source: PomBase
  • protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.056.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic proteinase yapsin-1 (EC:3.4.23.-)
Gene namesi
Name:yps1
ORF Names:SPCC1795.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1795.09.
PomBaseiSPCC1795.09. yps1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 500ExtracellularSequence analysisAdd BLAST483
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: PomBase
  • cell surface Source: PomBase
  • cell wall Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular region Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Endoplasmic reticulum, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000025559818 – 521Aspartic proteinase yapsin-1Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi460N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO59774.

Interactioni

Protein-protein interaction databases

BioGridi275503. 14 interactors.
MINTiMINT-4676089.

Structurei

3D structure databases

ProteinModelPortaliO59774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 409Peptidase A1PROSITE-ProRule annotationAdd BLAST343

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi471 – 474Poly-Ser4

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO59774.
OMAiFATENDQ.
OrthoDBiEOG092C2HTB.
PhylomeDBiO59774.

Family and domain databases

Gene3Di2.40.70.10. 3 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 3 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O59774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIWILIFFS FIKLVSSLQY TGNGVLALDF VAKTFPNQEN QLEKRDYTYS
60 70 80 90 100
PSGITSFPLD LQSYTYYTTT LSIGRPSISY TVAIDLDMPY TWLTYYNVMA
110 120 130 140 150
FNPAYLGIVN SGTQWSTDEL RYFLCKKESD SCYFGNASSS FHFVTSPSTF
160 170 180 190 200
FIRYDDNITV AGINVQDSLS YSHYQALPDF QFGITLKEYV PSSMLPYKGV
210 220 230 240 250
LGLAASTEIN SIDYSDSISS FSPPTFLEQL VKEDILAYPA FSMYLDNQGN
260 270 280 290 300
GSLLLGAVDT SKYQGQFVAL KQTKLTHYAV SIYSVQFLNS TFFSNYSIIT
310 320 330 340 350
DAYFQTRETY IYLPAELAYS VMDNAGAYLS EGYFALNCDE IDLEAALIFQ
360 370 380 390 400
FGCNSTIKVP ISLLVIGQVS NICLLGIRPS TDSEIVLGLL FFRNAYTFYH
410 420 430 440 450
QSQKMIAIGQ AFYNATSNLS AIVDQHIPGA LTCSQYPTSV ASTQLVQTSH
460 470 480 490 500
FTSTSLSAVN ISESVVYSYT SSSSMPSSAI PSFNISLISQ NAVANAGNSF
510 520
SPLSAMVIMM MSAVFLGLGI I
Length:521
Mass (Da):57,623
Last modified:August 1, 1998 - v1
Checksum:i21F002CF829175EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18644.1.
PIRiT41134.
RefSeqiNP_588035.1. NM_001023027.2.

Genome annotation databases

EnsemblFungiiSPCC1795.09.1; SPCC1795.09.1:pep; SPCC1795.09.
GeneIDi2538927.
KEGGispo:SPCC1795.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18644.1.
PIRiT41134.
RefSeqiNP_588035.1. NM_001023027.2.

3D structure databases

ProteinModelPortaliO59774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275503. 14 interactors.
MINTiMINT-4676089.

Protein family/group databases

MEROPSiA01.056.

Proteomic databases

PRIDEiO59774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1795.09.1; SPCC1795.09.1:pep; SPCC1795.09.
GeneIDi2538927.
KEGGispo:SPCC1795.09.

Organism-specific databases

EuPathDBiFungiDB:SPCC1795.09.
PomBaseiSPCC1795.09. yps1.

Phylogenomic databases

InParanoidiO59774.
OMAiFATENDQ.
OrthoDBiEOG092C2HTB.
PhylomeDBiO59774.

Miscellaneous databases

PROiO59774.

Family and domain databases

Gene3Di2.40.70.10. 3 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 3 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPS1_SCHPO
AccessioniPrimary (citable) accession number: O59774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.