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Protein

Chromatin modification-related protein vid21

Gene

vid21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein vid21
Alternative name(s):
Esa1-associated factor vid21
Vacuolar import and degradation protein 21
Gene namesi
Name:vid21
ORF Names:SPCC1795.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1795.08c.
PomBaseiSPCC1795.08c. vid21.

Subcellular locationi

GO - Cellular componenti

  • NuA4 histone acetyltransferase complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658221 – 994Chromatin modification-related protein vid21Add BLAST994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298Phosphoserine1 Publication1
Modified residuei378Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO59773.
PRIDEiO59773.

PTM databases

iPTMnetiO59773.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.1 Publication

Protein-protein interaction databases

BioGridi275686. 3 interactors.
IntActiO59773. 1 interactor.
MINTiMINT-8210866.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini475 – 548HSAPROSITE-ProRule annotationAdd BLAST74
Domaini713 – 773Myb-likePROSITE-ProRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili880 – 912Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi114 – 309Glu-richAdd BLAST196

Sequence similaritiesi

Belongs to the EAF1 family.Curated
Contains 1 HSA domain.PROSITE-ProRule annotation
Contains 1 Myb-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiO59773.
KOiK11397.
OMAiNVENHER.
OrthoDBiEOG092C3K1Y.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR014012. HSA_dom.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF07529. HSA. 1 hit.
[Graphical view]
SMARTiSM00573. HSA. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51204. HSA. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQKETKTSQ IALVDGEKLS ITDSFASLFT LDEEEENDSV DNEEIKLTKE
60 70 80 90 100
KHEKLLLLFW LHCKFPNGLE WLHSSSDLLP EQVSEWFNFY QKYRFKRGRN
110 120 130 140 150
FNLSARESVT PIVEEPIVPE EPDNLEGVSE ETPLKETSLE LSEEEIITSK
160 170 180 190 200
SPIPSPETIH KNIDVEEKET IEPTTPVKEV ETTAHAEEEK GPLTPDSEYA
210 220 230 240 250
ARQLTEELAN KSSQEEGVDK QLRVVEATEK EHEEDGNEEN VTVTKPVEVA
260 270 280 290 300
TDQVESKEVK KKEVSETTEP TAPPVTVAEV LEIEDKVPKV DEVEEVHSPE
310 320 330 340 350
AKVTENDVEN VQSGIDIEKT IQLLNNQEIP SEQQIISVDK ATESPVQEVA
360 370 380 390 400
VDVNEKPVDE IVEPSKLQME NKLPSEKSPT IDRTGVEAPL FELSVSMPLT
410 420 430 440 450
LIPPSKFSEP VKPELSSEAW LLRTEMSPLH LRLKNAHKYV LSDNWSHAYR
460 470 480 490 500
EEIVRQSLHH LTVAKEKGIW SFRQPKRQNE MPRLKTHRDY VLDEMQWMSI
510 520 530 540 550
DFSQERKWKI ILAHRMANWV MDYHQASDKC TVCTPASLSK NKKPYMQENE
560 570 580 590 600
HQKDSHEETF NEQIVSHFNL NDNNNNKVLS IPRDSLQFYN AVFSDDIFVT
610 620 630 640 650
TNSEQIQNCV LNVPMYGPPT ENNEYCEEIS EKYPITPVSR FAYAKTKLKS
660 670 680 690 700
TCAKASRKRL FNQLELSPPE SFMEKKARSD ENQLDGNKIK DDNQKLSSVG
710 720 730 740 750
TFSVRPPYPP SSKDIRPEAP WLPEEDELLL LLLRRYSFNW EFVASRLTPP
760 770 780 790 800
GLYIPLAEKR TAWDCFERWI QVDPRAANVQ LTGSHARLAQ QKLDESLRHS
810 820 830 840 850
DKVSQHLSLR DEGTPNHLIK HNSYFLLPTV SRHYRPITIF EAIRKILKKR
860 870 880 890 900
EFAKKPTMTK RAIAPSAAST EKLPPVPSPL ELSRLKSERE AQIQQIQAQR
910 920 930 940 950
NFAQLQSQNR ALRPQNAAVA AGAQQHNQQL AAFQAVAASQ NSSNNSSAGV
960 970 980 990
SPIAGRMVPR LQPYAVSSSL KLTPEQIHQL QQRKQTVPTT ERTQ
Length:994
Mass (Da):113,498
Last modified:July 11, 2012 - v2
Checksum:i0BBAA79E7CA8BD21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18643.2.
PIRiT41135.
RefSeqiNP_588036.2. NM_001023028.2.

Genome annotation databases

EnsemblFungiiSPCC1795.08c.1; SPCC1795.08c.1:pep; SPCC1795.08c.
GeneIDi2539114.
KEGGispo:SPCC1795.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA18643.2.
PIRiT41135.
RefSeqiNP_588036.2. NM_001023028.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275686. 3 interactors.
IntActiO59773. 1 interactor.
MINTiMINT-8210866.

PTM databases

iPTMnetiO59773.

Proteomic databases

MaxQBiO59773.
PRIDEiO59773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1795.08c.1; SPCC1795.08c.1:pep; SPCC1795.08c.
GeneIDi2539114.
KEGGispo:SPCC1795.08c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1795.08c.
PomBaseiSPCC1795.08c. vid21.

Phylogenomic databases

InParanoidiO59773.
KOiK11397.
OMAiNVENHER.
OrthoDBiEOG092C3K1Y.

Miscellaneous databases

PROiO59773.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR014012. HSA_dom.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF07529. HSA. 1 hit.
[Graphical view]
SMARTiSM00573. HSA. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51204. HSA. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAF_SCHPO
AccessioniPrimary (citable) accession number: O59773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 11, 2012
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.