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Protein

Probable proteasome subunit alpha type-7

Gene

pre10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.977

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-7 (EC:3.4.25.1)
Gene namesi
Name:pre10
ORF Names:SPCC1795.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1795.04c
PomBaseiSPCC1795.04c pre10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241011 – 253Probable proteasome subunit alpha type-7Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO59770
PaxDbiO59770
PRIDEiO59770

PTM databases

iPTMnetiO59770

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi275944, 5 interactors
STRINGi4896.SPCC1795.04c.1

Structurei

3D structure databases

ProteinModelPortaliO59770
SMRiO59770
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091086
InParanoidiO59770
KOiK02727
OMAiFELEMTW
OrthoDBiEOG092C47D8
PhylomeDBiO59770

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR037555 Proteasome_alpha_3
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF10 PTHR11599:SF10, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O59770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIGTGYDL GLFFSPDGRL FQAEYAYKAV ENASTCIGIK CEDGVILALE
60 70 80 90 100
KVVTSKLLKP RVNNRIGSVD RHIGIATTGF IPDGQHIVKR ARDEATSWRD
110 120 130 140 150
NYGSPIPGTV IADRLGNYVQ LFTCYSSVRP FGVMSFVATY DSEGPHLYMV
160 170 180 190 200
EPNGVYWGYN GAAAGKGRQV ARNELEKLNF SSLKMKDAVK EAARILYATH
210 220 230 240 250
DEENNKEHEI EMTWVGVETN GIHTPVPDEL LQEAEAYARR IADGEEEDIA

MQE
Length:253
Mass (Da):28,031
Last modified:August 1, 1998 - v1
Checksum:i2EE1087C8CDB9FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA18639.1
PIRiT41139
RefSeqiNP_588040.1, NM_001023032.2

Genome annotation databases

EnsemblFungiiSPCC1795.04c.1; SPCC1795.04c.1:pep; SPCC1795.04c
GeneIDi2539378
KEGGispo:SPCC1795.04c

Similar proteinsi

Entry informationi

Entry nameiPSA7_SCHPO
AccessioniPrimary (citable) accession number: O59770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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