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Protein

Kinesin-like protein 6

Gene

klp6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 1418ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • meiotic nuclear division Source: PomBase
  • microtubule-based movement Source: GO_Central
  • microtubule cytoskeleton organization involved in mitosis Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 6
Gene namesi
Name:klp6
ORF Names:SPBC1685.15c, SPBC649.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.15c.
PomBaseiSPBC1685.15c. klp6.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication
  • Chromosomecentromerekinetochore 1 Publication
  • Cytoplasmcytoskeletonspindle 1 Publication

  • Note: Cytoplasmic microtubules in interphase, mitotic kinetochores in metaphase and spindle midzone in anaphase and telophase.

GO - Cellular componenti

  • condensed nuclear chromosome kinetochore Source: PomBase
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • kinesin complex Source: GO_Central
  • microtubule cytoskeleton Source: PomBase
  • microtubule plus-end Source: PomBase
  • mitotic spindle Source: PomBase
  • mitotic spindle midzone Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
  • plus-end kinesin complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784Kinesin-like protein 6PRO_0000125389Add
BLAST

Proteomic databases

MaxQBiO59751.

Interactioni

Subunit structurei

Heterodimer with klp5.

Binary interactionsi

WithEntry#Exp.IntActNotes
klp5O143433EBI-1561745,EBI-1561765

Protein-protein interaction databases

BioGridi276253. 140 interactions.
IntActiO59751. 1 interaction.
MINTiMINT-4675888.

Structurei

3D structure databases

ProteinModelPortaliO59751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 389384Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili405 – 44036Sequence analysisAdd
BLAST
Coiled coili463 – 48321Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000183905.
InParanoidiO59751.
KOiK10401.
OMAiMWISIAK.
OrthoDBiEOG092C2D4G.
PhylomeDBiO59751.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 5 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGSSISVA VRVRPFTERE KGLLAETPKS KEFLGDGSLA VSNTSSNTFC
60 70 80 90 100
TNGIRKIVRV LDDNVLIFDP PEENPLAKVQ KSLLPAGKRF RDVRYAFDRL
110 120 130 140 150
FGEEASQEDV YKGTTEPLLD SVLQGYNATV FAYGATGCGK THTISGRPDD
160 170 180 190 200
PGIIFLTMRA LLDRVEGLKR TMNVDISVSY LEIYNEKIRD LLVQDPLSME
210 220 230 240 250
KPKSLNICED AEQNVSVPGL SYFTPTNLEE VMEIIIRGNS NRTMSPTEAN
260 270 280 290 300
AVSSRSHAVL QIYITQTPKS GEKQEESESQ NSHKVRSVFS FIDLAGSERA
310 320 330 340 350
SATKNRGKRL VEGANINRSL LALGNCINSL CEPRRRQHVP YRDSKLTRLL
360 370 380 390 400
KFSLGGNCRT CMIVCISPSS EHYDETHNTL KYGNRAKNIK TKVSRNVVSV
410 420 430 440 450
DRHVSEYVRT IYELRQKVSI LQKRIAEESK QLALNKEVRK ISSREIKMLD
460 470 480 490 500
ARSMLKNSFD GSRDLQKSLI EHVRTLRRIE DEITLTKMWI SIAKESDAMS
510 520 530 540 550
GHNIKSVETR LAKLYDQRSL ITAKVNPEEI CKTFQNSISH IVSSFKGEGA
560 570 580 590 600
DMYADMLQDD VDLLKSIIEN QILDAKHESE TFSSTSRKLI QNLFLLFPLL
610 620 630 640 650
PGNAIDVNES LARAFDQLVG IVPSEPTIQV PNLIEKGKAP LLSMFEIPRS
660 670 680 690 700
PSRFKARSPS KAARVLKKPL KKRVRFSEVP TTSSVPPVEI KNKDSKPKVE
710 720 730 740 750
KSLDKHNMNN DRSFLVPSRD ARNSLTSLSL HSNVAKNKSS HSSKWPTHTL
760 770 780
SPIITTALKQ PVRRISLVSQ PLQKTGGTEN TPNA
Length:784
Mass (Da):87,796
Last modified:August 1, 1998 - v1
Checksum:iEBE985FF79C18BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072925 Genomic DNA. Translation: BAB69886.1.
CU329671 Genomic DNA. Translation: CAA20063.1.
AB027906 Genomic DNA. Translation: BAA87210.1.
PIRiT40594.
RefSeqiXP_001713122.1. XM_001713070.2.

Genome annotation databases

EnsemblFungiiSPBC1685.15c.1; SPBC1685.15c.1:pep; SPBC1685.15c.
GeneIDi2539700.
KEGGispo:SPBC1685.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072925 Genomic DNA. Translation: BAB69886.1.
CU329671 Genomic DNA. Translation: CAA20063.1.
AB027906 Genomic DNA. Translation: BAA87210.1.
PIRiT40594.
RefSeqiXP_001713122.1. XM_001713070.2.

3D structure databases

ProteinModelPortaliO59751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276253. 140 interactions.
IntActiO59751. 1 interaction.
MINTiMINT-4675888.

Proteomic databases

MaxQBiO59751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1685.15c.1; SPBC1685.15c.1:pep; SPBC1685.15c.
GeneIDi2539700.
KEGGispo:SPBC1685.15c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.15c.
PomBaseiSPBC1685.15c. klp6.

Phylogenomic databases

HOGENOMiHOG000183905.
InParanoidiO59751.
KOiK10401.
OMAiMWISIAK.
OrthoDBiEOG092C2D4G.
PhylomeDBiO59751.

Enzyme and pathway databases

ReactomeiR-SPO-983189. Kinesins.

Miscellaneous databases

PROiO59751.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 5 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLP6_SCHPO
AccessioniPrimary (citable) accession number: O59751
Secondary accession number(s): Q9UTZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.