Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein 6

Gene

klp6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi134 – 141ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: PomBase
  • microtubule binding Source: PomBase

GO - Biological processi

  • chromosome movement towards spindle pole Source: PomBase
  • cytoplasmic microtubule depolymerization Source: PomBase
  • deactivation of mitotic spindle assembly checkpoint Source: PomBase
  • microtubule depolymerization Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • mitotic metaphase chromosome recapture Source: PomBase
  • mitotic sister chromatid biorientation Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • mitotic spindle organization Source: PomBase
  • protein localization to kinetochore Source: PomBase

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 6
Gene namesi
Name:klp6
ORF Names:SPBC1685.15c, SPBC649.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.15c
PomBaseiSPBC1685.15c klp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253891 – 784Kinesin-like protein 6Add BLAST784

Proteomic databases

MaxQBiO59751
PaxDbiO59751
PRIDEiO59751

PTM databases

iPTMnetiO59751

Interactioni

Subunit structurei

Heterodimer with klp5.

Binary interactionsi

WithEntry#Exp.IntActNotes
klp5O143433EBI-1561745,EBI-1561765

GO - Molecular functioni

  • microtubule binding Source: PomBase

Protein-protein interaction databases

BioGridi276253, 141 interactors
IntActiO59751, 1 interactor
STRINGi4896.SPBC1685.15c.1

Structurei

3D structure databases

ProteinModelPortaliO59751
SMRiO59751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 389Kinesin motorPROSITE-ProRule annotationAdd BLAST384

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili405 – 440Sequence analysisAdd BLAST36
Coiled coili463 – 483Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000183905
InParanoidiO59751
KOiK10401
OrthoDBiEOG092C2D4G
PhylomeDBiO59751

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O59751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGSSISVA VRVRPFTERE KGLLAETPKS KEFLGDGSLA VSNTSSNTFC
60 70 80 90 100
TNGIRKIVRV LDDNVLIFDP PEENPLAKVQ KSLLPAGKRF RDVRYAFDRL
110 120 130 140 150
FGEEASQEDV YKGTTEPLLD SVLQGYNATV FAYGATGCGK THTISGRPDD
160 170 180 190 200
PGIIFLTMRA LLDRVEGLKR TMNVDISVSY LEIYNEKIRD LLVQDPLSME
210 220 230 240 250
KPKSLNICED AEQNVSVPGL SYFTPTNLEE VMEIIIRGNS NRTMSPTEAN
260 270 280 290 300
AVSSRSHAVL QIYITQTPKS GEKQEESESQ NSHKVRSVFS FIDLAGSERA
310 320 330 340 350
SATKNRGKRL VEGANINRSL LALGNCINSL CEPRRRQHVP YRDSKLTRLL
360 370 380 390 400
KFSLGGNCRT CMIVCISPSS EHYDETHNTL KYGNRAKNIK TKVSRNVVSV
410 420 430 440 450
DRHVSEYVRT IYELRQKVSI LQKRIAEESK QLALNKEVRK ISSREIKMLD
460 470 480 490 500
ARSMLKNSFD GSRDLQKSLI EHVRTLRRIE DEITLTKMWI SIAKESDAMS
510 520 530 540 550
GHNIKSVETR LAKLYDQRSL ITAKVNPEEI CKTFQNSISH IVSSFKGEGA
560 570 580 590 600
DMYADMLQDD VDLLKSIIEN QILDAKHESE TFSSTSRKLI QNLFLLFPLL
610 620 630 640 650
PGNAIDVNES LARAFDQLVG IVPSEPTIQV PNLIEKGKAP LLSMFEIPRS
660 670 680 690 700
PSRFKARSPS KAARVLKKPL KKRVRFSEVP TTSSVPPVEI KNKDSKPKVE
710 720 730 740 750
KSLDKHNMNN DRSFLVPSRD ARNSLTSLSL HSNVAKNKSS HSSKWPTHTL
760 770 780
SPIITTALKQ PVRRISLVSQ PLQKTGGTEN TPNA
Length:784
Mass (Da):87,796
Last modified:August 1, 1998 - v1
Checksum:iEBE985FF79C18BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072925 Genomic DNA Translation: BAB69886.1
CU329671 Genomic DNA Translation: CAA20063.1
AB027906 Genomic DNA Translation: BAA87210.1
PIRiT40594
RefSeqiXP_001713122.1, XM_001713070.2

Genome annotation databases

EnsemblFungiiSPBC1685.15c.1; SPBC1685.15c.1:pep; SPBC1685.15c
KEGGispo:SPBC1685.15c

Similar proteinsi

Entry informationi

Entry nameiKLP6_SCHPO
AccessioniPrimary (citable) accession number: O59751
Secondary accession number(s): Q9UTZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health