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Protein

Vacuolar membrane amino acid uptake transporter fnx2

Gene

fnx2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

MFS-type transporter involved in vacuolar amino acid uptake.1 Publication

GO - Molecular functioni

  • L-asparagine transmembrane transporter activity Source: PomBase
  • L-isoleucine transmembrane transporter activity Source: PomBase
  • L-lysine transmembrane transporter activity Source: PomBase

GO - Biological processi

  • asparagine transmembrane import into vacuole Source: PomBase
  • isoleucine transmembrane transport Source: PomBase
  • lysine transmembrane import into vacuole Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.48.4. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar membrane amino acid uptake transporter fnx2
Gene namesi
Name:fnx2
ORF Names:SPBC3E7.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3E7.06c.
PomBaseiSPBC3E7.06c. fnx2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei123 – 145HelicalSequence analysisAdd BLAST23
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • fungal-type vacuole Source: PomBase
  • fungal-type vacuole membrane Source: PomBase
  • integral component of vacuolar membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003727141 – 577Vacuolar membrane amino acid uptake transporter fnx2Add BLAST577

Proteomic databases

MaxQBiO59726.
PRIDEiO59726.

Interactioni

Protein-protein interaction databases

MINTiMINT-4675707.

Structurei

3D structure databases

ProteinModelPortaliO59726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000214685.
InParanoidiO59726.
OMAiQNTSWIA.
OrthoDBiEOG092C21WF.
PhylomeDBiO59726.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPRTKSPN TNRGQGLRSE RSALLNDSLS SLNGNSSYDS IKDSSKNNKD
60 70 80 90 100
VAEVNEYPRR PESSVSVVSN SPHRQDAATT NTVSTVSVSK VLPALLLGVV
110 120 130 140 150
LAALDNTIVA STYTKIGAEF GKFSQVSWTA TAYMISCTAF QPLFGKFCDI
160 170 180 190 200
YGRKKTLLAA YCVFGIGCFL CGTSRSLWQL VAARAIAGIG GGGMNSTVSI
210 220 230 240 250
LMSDIVPLKQ RGTYQGIINV FFAIGSSLGG PVGGYFADQY TWRIGFLIQV
260 270 280 290 300
PLIAIAFLCV YFTLNLPHHN HVSFMTRFRK IDLKGLILLI IGVTTMTCAF
310 320 330 340 350
TLGGNVREWN DPVVISLLIA SSISYLSFVY VEAFVAFEPL APMDVLTERT
360 370 380 390 400
CLSSYLCNFF HSVANFGWIY GMPLFFQSIK NEGAEKSGIR LIPMIIGSSL
410 420 430 440 450
GSLLGGAVIS LTGNYKKITV GSYFFGSVAA LFMLRYGYSN FNWEYAVYPF
460 470 480 490 500
SGGLGNGIAV TTTLVAIIHA SPSAFQASAI ATSYLFRSNG CVLGVSISSS
510 520 530 540 550
IVQTVLGIKL RKSLDFDVDE LLHHLRKDIS YVHRLPEEIR QTVLDALLGS
560 570
IHYSFLFVSF MFFCAFVCSM FIKNRNL
Length:577
Mass (Da):62,900
Last modified:August 1, 1998 - v1
Checksum:iF5999403CA97F64A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38Y → N in BAA87255 (PubMed:10759889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19010.1.
AB027951 Genomic DNA. Translation: BAA87255.1.
PIRiT40380.
RefSeqiNP_596093.1. NM_001022009.2.

Genome annotation databases

EnsemblFungiiSPBC3E7.06c.1; SPBC3E7.06c.1:pep; SPBC3E7.06c.
GeneIDi2541016.
KEGGispo:SPBC3E7.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19010.1.
AB027951 Genomic DNA. Translation: BAA87255.1.
PIRiT40380.
RefSeqiNP_596093.1. NM_001022009.2.

3D structure databases

ProteinModelPortaliO59726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4675707.

Protein family/group databases

TCDBi2.A.1.48.4. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiO59726.
PRIDEiO59726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC3E7.06c.1; SPBC3E7.06c.1:pep; SPBC3E7.06c.
GeneIDi2541016.
KEGGispo:SPBC3E7.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC3E7.06c.
PomBaseiSPBC3E7.06c. fnx2.

Phylogenomic databases

HOGENOMiHOG000214685.
InParanoidiO59726.
OMAiQNTSWIA.
OrthoDBiEOG092C21WF.
PhylomeDBiO59726.

Miscellaneous databases

PROiO59726.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFNX2_SCHPO
AccessioniPrimary (citable) accession number: O59726
Secondary accession number(s): Q9US91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.