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Protein

Vacuolar membrane amino acid uptake transporter fnx2

Gene

fnx2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

MFS-type transporter involved in vacuolar amino acid uptake.1 Publication

GO - Molecular functioni

  • L-asparagine transmembrane transporter activity Source: PomBase
  • L-isoleucine transmembrane transporter activity Source: PomBase
  • L-lysine transmembrane transporter activity Source: PomBase

GO - Biological processi

  • asparagine transmembrane import into vacuole Source: PomBase
  • isoleucine transmembrane transport Source: PomBase

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.1.48.4 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar membrane amino acid uptake transporter fnx2
Gene namesi
Name:fnx2
ORF Names:SPBC3E7.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3E7.06c
PomBaseiSPBC3E7.06c fnx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei123 – 145HelicalSequence analysisAdd BLAST23
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003727141 – 577Vacuolar membrane amino acid uptake transporter fnx2Add BLAST577

Proteomic databases

MaxQBiO59726
PaxDbiO59726
PRIDEiO59726

PTM databases

iPTMnetiO59726

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC3E7.06c.1

Structurei

3D structure databases

ProteinModelPortaliO59726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000214685
InParanoidiO59726
OMAiWFTIRIP
OrthoDBiEOG092C21WF
PhylomeDBiO59726

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

O59726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPRTKSPN TNRGQGLRSE RSALLNDSLS SLNGNSSYDS IKDSSKNNKD
60 70 80 90 100
VAEVNEYPRR PESSVSVVSN SPHRQDAATT NTVSTVSVSK VLPALLLGVV
110 120 130 140 150
LAALDNTIVA STYTKIGAEF GKFSQVSWTA TAYMISCTAF QPLFGKFCDI
160 170 180 190 200
YGRKKTLLAA YCVFGIGCFL CGTSRSLWQL VAARAIAGIG GGGMNSTVSI
210 220 230 240 250
LMSDIVPLKQ RGTYQGIINV FFAIGSSLGG PVGGYFADQY TWRIGFLIQV
260 270 280 290 300
PLIAIAFLCV YFTLNLPHHN HVSFMTRFRK IDLKGLILLI IGVTTMTCAF
310 320 330 340 350
TLGGNVREWN DPVVISLLIA SSISYLSFVY VEAFVAFEPL APMDVLTERT
360 370 380 390 400
CLSSYLCNFF HSVANFGWIY GMPLFFQSIK NEGAEKSGIR LIPMIIGSSL
410 420 430 440 450
GSLLGGAVIS LTGNYKKITV GSYFFGSVAA LFMLRYGYSN FNWEYAVYPF
460 470 480 490 500
SGGLGNGIAV TTTLVAIIHA SPSAFQASAI ATSYLFRSNG CVLGVSISSS
510 520 530 540 550
IVQTVLGIKL RKSLDFDVDE LLHHLRKDIS YVHRLPEEIR QTVLDALLGS
560 570
IHYSFLFVSF MFFCAFVCSM FIKNRNL
Length:577
Mass (Da):62,900
Last modified:August 1, 1998 - v1
Checksum:iF5999403CA97F64A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38Y → N in BAA87255 (PubMed:10759889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19010.1
AB027951 Genomic DNA Translation: BAA87255.1
PIRiT40380
RefSeqiNP_596093.1, NM_001022009.2

Genome annotation databases

EnsemblFungiiSPBC3E7.06c.1; SPBC3E7.06c.1:pep; SPBC3E7.06c
GeneIDi2541016
KEGGispo:SPBC3E7.06c

Similar proteinsi

Entry informationi

Entry nameiFNX2_SCHPO
AccessioniPrimary (citable) accession number: O59726
Secondary accession number(s): Q9US91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health