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O59718 (NEM1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear envelope morphology protein 1

EC=3.1.3.16
Gene names
Name:nem1
ORF Names:SPBC3B8.10c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Component of the nem1-spo7 complex By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein By similarity Ref.2.

Sequence similarities

Belongs to the Dullard family.

Contains 1 FCP1 homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Nuclear envelope morphology protein 1
PRO_0000315975

Regions

Transmembrane123 – 13917Helical; Potential
Domain299 – 460162FCP1 homology
Compositional bias158 – 278121Ser-rich

Amino acid modifications

Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O59718 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 012BBD6EF067090F

FASTA47654,598
        10         20         30         40         50         60 
MNSIARLSDE INKAILATPL DDDEADKEKL ANARGRASSA TLRHYNRRRS SYSASSLSSL 

        70         80         90        100        110        120 
SSKPTEKEVP TRNEKPKHAN IMRVVVYWIR VFLKRIYTFF VHSARVFLYH FLNEEKEFTL 

       130        140        150        160        170        180 
ASFFWGLCRF VFFPVLLSYK RREMLPPQPS VRRPRFYSSY SYPSSHQDPA YSSFKRHRSS 

       190        200        210        220        230        240 
NSYSSSSNGN HVRFQPSIAE EEISFNSFSN SLNSEEDVCV SPMKPKEVSL MGKANSNRSG 

       250        260        270        280        290        300 
HSHQPQSTQF SPPANDNISK LPSSFTIVND PLKSPSSSRL RIRNITLCAD KIPRPLLNSK 

       310        320        330        340        350        360 
LPRKTLVLDL DETLIHSVSR GSRTTSGQPI EVHVPGEHPI LYYIHKRPHL DYFLSNVSQW 

       370        380        390        400        410        420 
FRLILFTASV QPYADPIIDY LERDKKIFAK RYYRQHCALV DSSFVKDISI CNIHLSRIMI 

       430        440        450        460        470 
IDNSPASYNA HKENAIPIEG WISDPSDVDL LNLLSFLHAL QYVHDVRDLL GLRLAK 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA18299.1.
PIRT40330.
RefSeqNP_596404.1. NM_001022323.2.

3D structure databases

ProteinModelPortalO59718.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277536. 93 interactions.
MINTMINT-4675647.
STRING4896.SPBC3B8.10c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC3B8.10c.1; SPBC3B8.10c.1:pep; SPBC3B8.10c.
GeneID2541021.
KEGGspo:SPBC3B8.10c.

Organism-specific databases

PomBaseSPBC3B8.10c.

Phylogenomic databases

eggNOGCOG5190.
KOK17617.
OrthoDBEOG7VDZ0W.
PhylomeDBO59718.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802135.

Entry information

Entry nameNEM1_SCHPO
AccessionPrimary (citable) accession number: O59718
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names