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O59718

- NEM1_SCHPO

UniProt

O59718 - NEM1_SCHPO

Protein

Nuclear envelope morphology protein 1

Gene

nem1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ascospore formation Source: PomBase
    2. nuclear envelope organization Source: PomBase
    3. protein dephosphorylation Source: PomBase
    4. regulation of lipid biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear envelope morphology protein 1 (EC:3.1.3.16)
    Gene namesi
    Name:nem1
    ORF Names:SPBC3B8.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC3B8.10c.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication. Nucleus membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. Nem1-Spo7 phosphatase complex Source: PomBase
    5. nuclear membrane Source: UniProtKB-SubCell
    6. nuclear outer membrane-endoplasmic reticulum membrane network Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Nuclear envelope morphology protein 1PRO_0000315975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO59718.

    Interactioni

    Subunit structurei

    Component of the nem1-spo7 complex.By similarity

    Protein-protein interaction databases

    BioGridi277536. 94 interactions.
    MINTiMINT-4675647.
    STRINGi4896.SPBC3B8.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59718.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei123 – 13917HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini299 – 460162FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi158 – 278121Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Dullard family.Curated
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5190.
    KOiK17617.
    OrthoDBiEOG7VDZ0W.
    PhylomeDBiO59718.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59718-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSIARLSDE INKAILATPL DDDEADKEKL ANARGRASSA TLRHYNRRRS    50
    SYSASSLSSL SSKPTEKEVP TRNEKPKHAN IMRVVVYWIR VFLKRIYTFF 100
    VHSARVFLYH FLNEEKEFTL ASFFWGLCRF VFFPVLLSYK RREMLPPQPS 150
    VRRPRFYSSY SYPSSHQDPA YSSFKRHRSS NSYSSSSNGN HVRFQPSIAE 200
    EEISFNSFSN SLNSEEDVCV SPMKPKEVSL MGKANSNRSG HSHQPQSTQF 250
    SPPANDNISK LPSSFTIVND PLKSPSSSRL RIRNITLCAD KIPRPLLNSK 300
    LPRKTLVLDL DETLIHSVSR GSRTTSGQPI EVHVPGEHPI LYYIHKRPHL 350
    DYFLSNVSQW FRLILFTASV QPYADPIIDY LERDKKIFAK RYYRQHCALV 400
    DSSFVKDISI CNIHLSRIMI IDNSPASYNA HKENAIPIEG WISDPSDVDL 450
    LNLLSFLHAL QYVHDVRDLL GLRLAK 476
    Length:476
    Mass (Da):54,598
    Last modified:August 1, 1998 - v1
    Checksum:i012BBD6EF067090F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA18299.1.
    PIRiT40330.
    RefSeqiNP_596404.1. NM_001022323.2.

    Genome annotation databases

    EnsemblFungiiSPBC3B8.10c.1; SPBC3B8.10c.1:pep; SPBC3B8.10c.
    GeneIDi2541021.
    KEGGispo:SPBC3B8.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA18299.1 .
    PIRi T40330.
    RefSeqi NP_596404.1. NM_001022323.2.

    3D structure databases

    ProteinModelPortali O59718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277536. 94 interactions.
    MINTi MINT-4675647.
    STRINGi 4896.SPBC3B8.10c-1.

    Proteomic databases

    MaxQBi O59718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC3B8.10c.1 ; SPBC3B8.10c.1:pep ; SPBC3B8.10c .
    GeneIDi 2541021.
    KEGGi spo:SPBC3B8.10c.

    Organism-specific databases

    PomBasei SPBC3B8.10c.

    Phylogenomic databases

    eggNOGi COG5190.
    KOi K17617.
    OrthoDBi EOG7VDZ0W.
    PhylomeDBi O59718.

    Miscellaneous databases

    NextBioi 20802135.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNEM1_SCHPO
    AccessioniPrimary (citable) accession number: O59718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3