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O59711

- LYS9_SCHPO

UniProt

O59711 - LYS9_SCHPO

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Protein

Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

Gene

lys9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH.

Pathwayi

GO - Molecular functioni

  1. saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Source: PomBase

GO - Biological processi

  1. lysine biosynthetic process Source: PomBase
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_208292. Lysine catabolism.
UniPathwayiUPA00033; UER00033.

Names & Taxonomyi

Protein namesi
Recommended name:
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] (EC:1.5.1.10)
Alternative name(s):
Saccharopine reductase
Gene namesi
Name:lys9By similarity
ORF Names:SPBC3B8.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC3B8.03.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]PRO_0000316856Add
BLAST

Proteomic databases

MaxQBiO59711.
PaxDbiO59711.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277424. 6 interactions.
MINTiMINT-4675591.
STRINGi4896.SPBC3B8.03-1.

Structurei

3D structure databases

ProteinModelPortaliO59711.
SMRiO59711. Positions 3-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the saccharopine dehydrogenase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG1748.
HOGENOMiHOG000023158.
InParanoidiO59711.
KOiK00293.
OMAiYAVKTIE.
OrthoDBiEOG7FJH8S.
PhylomeDBiO59711.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR005097. Saccharopine_DH/HSpermid_syn.
[Graphical view]
PfamiPF03435. Saccharop_dh. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59711-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSILLLGSG FVAHPTLEYL SRRKENNITV ACRTLSKAEA FINGIPNSKA
60 70 80 90 100
IALDVNDEAA LEKAVSEHDL TISLIPYTYH ATVMKAAIKH GKHVCTTSYV
110 120 130 140 150
NPKMAELEEA AIKAGSICMN EIGVDPGIDH LYAIKTIEEV HKAGGKIKSF
160 170 180 190 200
LSYCGGLPAP EDSNNPLGYK FSWSSRGVLL ALRNSAKFYE NGKLVEIDGK
210 220 230 240 250
DLMETAKPYF IYPGYAFVCY PNRDSTVYQE RYQIPEAETI IRGTLRYQGF
260 270 280 290 300
PEFIHCLVDM GFLDETAQEY LSPEAPALPW KEVTARVIKA ESSSEADLIK
310 320 330 340 350
KISSIHKFKD EDDKKRILNG LKWLGMFSSK PVTPRGNPLD TLCATLEELM
360 370 380 390 400
QYEEGERDML ILQHKFEVET KEGKRQTRTC TLLDYGVPNG YTSMAKLVGV
410 420 430 440 450
PCGVATQQIL DGVINTPGVL APNDMKLCGP LIDTLAKEGI RLEEEIIDEE
Length:450
Mass (Da):49,938
Last modified:August 1, 1998 - v1
Checksum:i1AEE17A423715C71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA18292.1.
PIRiT40337.
RefSeqiNP_596411.1. NM_001022330.2.

Genome annotation databases

EnsemblFungiiSPBC3B8.03.1; SPBC3B8.03.1:pep; SPBC3B8.03.
GeneIDi2540908.
KEGGispo:SPBC3B8.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA18292.1 .
PIRi T40337.
RefSeqi NP_596411.1. NM_001022330.2.

3D structure databases

ProteinModelPortali O59711.
SMRi O59711. Positions 3-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277424. 6 interactions.
MINTi MINT-4675591.
STRINGi 4896.SPBC3B8.03-1.

Proteomic databases

MaxQBi O59711.
PaxDbi O59711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC3B8.03.1 ; SPBC3B8.03.1:pep ; SPBC3B8.03 .
GeneIDi 2540908.
KEGGi spo:SPBC3B8.03.

Organism-specific databases

PomBasei SPBC3B8.03.

Phylogenomic databases

eggNOGi COG1748.
HOGENOMi HOG000023158.
InParanoidi O59711.
KOi K00293.
OMAi YAVKTIE.
OrthoDBi EOG7FJH8S.
PhylomeDBi O59711.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00033 .
Reactomei REACT_208292. Lysine catabolism.

Miscellaneous databases

NextBioi 20802023.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR016040. NAD(P)-bd_dom.
IPR005097. Saccharopine_DH/HSpermid_syn.
[Graphical view ]
Pfami PF03435. Saccharop_dh. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLYS9_SCHPO
AccessioniPrimary (citable) accession number: O59711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3