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O59711

- LYS9_SCHPO

UniProt

O59711 - LYS9_SCHPO

Protein

Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

Gene

lys9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Source: PomBase

    GO - Biological processi

    1. lysine biosynthetic process Source: PomBase
    2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_208292. Lysine catabolism.
    UniPathwayiUPA00033; UER00033.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] (EC:1.5.1.10)
    Alternative name(s):
    Saccharopine reductase
    Gene namesi
    Name:lys9By similarity
    ORF Names:SPBC3B8.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC3B8.03.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]PRO_0000316856Add
    BLAST

    Proteomic databases

    MaxQBiO59711.
    PaxDbiO59711.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi277424. 6 interactions.
    MINTiMINT-4675591.
    STRINGi4896.SPBC3B8.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59711.
    SMRiO59711. Positions 3-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the saccharopine dehydrogenase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG1748.
    HOGENOMiHOG000023158.
    KOiK00293.
    OMAiYAVKTIE.
    OrthoDBiEOG7FJH8S.
    PhylomeDBiO59711.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR005097. Saccharopine_DH/HSpermid_syn.
    [Graphical view]
    PfamiPF03435. Saccharop_dh. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59711-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSILLLGSG FVAHPTLEYL SRRKENNITV ACRTLSKAEA FINGIPNSKA    50
    IALDVNDEAA LEKAVSEHDL TISLIPYTYH ATVMKAAIKH GKHVCTTSYV 100
    NPKMAELEEA AIKAGSICMN EIGVDPGIDH LYAIKTIEEV HKAGGKIKSF 150
    LSYCGGLPAP EDSNNPLGYK FSWSSRGVLL ALRNSAKFYE NGKLVEIDGK 200
    DLMETAKPYF IYPGYAFVCY PNRDSTVYQE RYQIPEAETI IRGTLRYQGF 250
    PEFIHCLVDM GFLDETAQEY LSPEAPALPW KEVTARVIKA ESSSEADLIK 300
    KISSIHKFKD EDDKKRILNG LKWLGMFSSK PVTPRGNPLD TLCATLEELM 350
    QYEEGERDML ILQHKFEVET KEGKRQTRTC TLLDYGVPNG YTSMAKLVGV 400
    PCGVATQQIL DGVINTPGVL APNDMKLCGP LIDTLAKEGI RLEEEIIDEE 450
    Length:450
    Mass (Da):49,938
    Last modified:August 1, 1998 - v1
    Checksum:i1AEE17A423715C71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA18292.1.
    PIRiT40337.
    RefSeqiNP_596411.1. NM_001022330.2.

    Genome annotation databases

    EnsemblFungiiSPBC3B8.03.1; SPBC3B8.03.1:pep; SPBC3B8.03.
    GeneIDi2540908.
    KEGGispo:SPBC3B8.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA18292.1 .
    PIRi T40337.
    RefSeqi NP_596411.1. NM_001022330.2.

    3D structure databases

    ProteinModelPortali O59711.
    SMRi O59711. Positions 3-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277424. 6 interactions.
    MINTi MINT-4675591.
    STRINGi 4896.SPBC3B8.03-1.

    Proteomic databases

    MaxQBi O59711.
    PaxDbi O59711.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC3B8.03.1 ; SPBC3B8.03.1:pep ; SPBC3B8.03 .
    GeneIDi 2540908.
    KEGGi spo:SPBC3B8.03.

    Organism-specific databases

    PomBasei SPBC3B8.03.

    Phylogenomic databases

    eggNOGi COG1748.
    HOGENOMi HOG000023158.
    KOi K00293.
    OMAi YAVKTIE.
    OrthoDBi EOG7FJH8S.
    PhylomeDBi O59711.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00033 .
    Reactomei REACT_208292. Lysine catabolism.

    Miscellaneous databases

    NextBioi 20802023.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR005097. Saccharopine_DH/HSpermid_syn.
    [Graphical view ]
    Pfami PF03435. Saccharop_dh. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLYS9_SCHPO
    AccessioniPrimary (citable) accession number: O59711
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3