Reviewed,
UniProtKB/Swiss-Prot O59711 (LYS9_SCHPO)
Last modified
February 9, 2010.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Saccharopine dehydrogenase [NADP+, L-glutamate-forming] EC=1.5.1.10 Alternative name(s): Saccharopine reductase | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 450 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH. UniProtKB Q9P4R4 |
| Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3. UniProtKB Q9P4R4 |
| Subunit structure | Homodimer By similarity. UniProtKB Q9P4R4 |
| Subcellular location | |
| Sequence similarities | Belongs to the saccharopine dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Lysine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Ref.2 Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NADP+, L-glutamate-forming) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 450 | 450 | Saccharopine dehydrogenase [NADP+, L-glutamate-forming] | PRO_0000316856 | |||
Sequences
| ||||||||||||||||||
References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329671 Genomic DNA. Translation: CAA18292.1. |
| PIR | T40337. |
| RefSeq | NP_596411.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FF9 based on UniProtKB Q9P4R4. |
| SMR | O59711. Positions 3-447. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O59711. |
Genome annotation databases | |
| GeneID | 2540908. |
| GenomeReviews | Gene locus lys9 in contig CU329671_GR. |
| KEGG | spo:SPBC3B8.03. |
| NMPDR | fig|4896.1.peg.2277. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC3B8.03. |
Phylogenomic databases | |
| eggNOG | fuNOG05861. |
| HOGENOM | HBG324692. |
| OMA | PYFIYPG. |
| OrthoDB | EOG9576Q0. |
| PhylomeDB | O59711. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.10. 653. |
Gene expression databases | |
| ArrayExpress | O59711. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR005097. Saccharopine_DH/HSpermid_syn. [Graphical view] |
| Pfam | PF03435. Saccharop_dh. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LYS9_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O59711 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


