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Protein

Probable NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

arh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Serves as the first electron transfer protein in all the mitochondrial P450 systems.By similarity
Acts as an electron transfer protein. Essential for viability.By similarity

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27FAD; via amide nitrogenBy similarity1
Binding sitei48FADBy similarity1
Binding sitei56FAD; via amide nitrogenBy similarity1
Binding sitei92FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei220NADPBy similarity1
Binding sitei375FAD; via amide nitrogenBy similarity1
Binding sitei382NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi164 – 167NADPBy similarity4
Nucleotide bindingi208 – 209NADPBy similarity2
Nucleotide bindingi382 – 384FADBy similarity3

GO - Molecular functioni

  • electron transfer activity Source: PomBase
  • ferredoxin-NADP+ reductase activity Source: PomBase
  • flavin adenine dinucleotide binding Source: PomBase
  • NADP binding Source: PomBase
  • NADPH-adrenodoxin reductase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiR-SPO-2395516 Electron transport from NADPH to Ferredoxin

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial (EC:1.18.1.6)
Short name:
AR
Short name:
Adrenodoxin reductase
Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name:
Ferredoxin reductase
Gene namesi
Name:arh1
ORF Names:SPBC3B8.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3B8.01c
PomBaseiSPBC3B8.01c arh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000033725939 – 469Probable NADPH:adrenodoxin oxidoreductase, mitochondrialAdd BLAST431

Proteomic databases

MaxQBiO59710
PaxDbiO59710
PRIDEiO59710

PTM databases

SwissPalmiO59710

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC3B8.01c.1

Structurei

3D structure databases

ProteinModelPortaliO59710
SMRiO59710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000249250
InParanoidiO59710
KOiK18914
OMAiWGLRFFR
OrthoDBiEOG092C2YAM
PhylomeDBiO59710

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O59710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRFIKRTY STQTSSPVVG IIGSGPAAFY TAHRLLRNDP NVKIDMFESR
60 70 80 90 100
PVPFGLVRYG VAPDHPEVKH VEHKFSEIAE STQFRFLGNV NVGTDVSLRD
110 120 130 140 150
LTKNYDCLVL AYGAAGDKRL GIPGEDLSGV YSAREVVGWY NSDPRNQNLE
160 170 180 190 200
LDLSQVEDAV VIGHGNVSLD VARILLSNPA QLSPTDINPL FLKSLERSNL
210 220 230 240 250
KRLHIVGRRN IFSVSFTIKE LRELFALSSA VFFAPSFNYS TKWMNETDAS
260 270 280 290 300
GLDRPRKRLL KLLVSEIQKA VSEKRVAPYS KDKKCWNLEF GLTPVEILGH
310 320 330 340 350
KGNVENVRFQ ITDSIRTDAE SKFTTIPAQL FIRSIGYKSM PLPGMKDVGV
360 370 380 390 400
PFDDAKGIVK NVNGFVRPGI YTSGWVKHGP IGVIATTMMD AFATADTITK
410 420 430 440 450
DWKSKKEFLK NSKLGWDGLK KNIKTPVIHW KDWKVIRNAE IERGLRHESL
460
SEKFRSNEDM IKLIYPGKK
Length:469
Mass (Da):52,716
Last modified:August 1, 1998 - v1
Checksum:i2AFBDBCF86C57291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18290.1
PIRiT40339
RefSeqiNP_596413.1, NM_001022332.2

Genome annotation databases

EnsemblFungiiSPBC3B8.01c.1; SPBC3B8.01c.1:pep; SPBC3B8.01c
GeneIDi2541049
KEGGispo:SPBC3B8.01c

Similar proteinsi

Entry informationi

Entry nameiADRO_SCHPO
AccessioniPrimary (citable) accession number: O59710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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