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O59702

- CLR6_SCHPO

UniProt

O59702 - CLR6_SCHPO

Protein

Histone deacetylase clr6

Gene

clr6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation.1 Publication

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: PomBase
    2. histone deacetylase activity (H3-K9 specific) Source: PomBase
    3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    7. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin remodeling Source: PomBase
    2. chromatin silencing at centromere Source: PomBase
    3. chromatin silencing at silent mating-type cassette Source: PomBase
    4. chromosome condensation Source: PomBase
    5. histone deacetylation Source: PomBase
    6. histone H3 deacetylation Source: GOC
    7. mitotic sister chromatid segregation Source: PomBase
    8. negative regulation of transcription from RNA polymerase II promoter Source: PomBase
    9. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
    10. regulation of histone H3-K9 methylation Source: PomBase
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase clr6 (EC:3.5.1.98)
    Alternative name(s):
    Cryptic loci regulator 6
    Gene namesi
    Name:clr6
    ORF Names:SPBC36.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC36.05c.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nuclear chromatin Source: PomBase
    3. Rpd3L complex Source: PomBase
    4. Rpd3L-Expanded complex Source: PomBase
    5. Rpd3S complex Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Histone deacetylase clr6PRO_0000114740Add
    BLAST

    Proteomic databases

    MaxQBiO59702.

    Interactioni

    Subunit structurei

    Heterotetramer of alp13, clr6, prw1 and pst2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    pst2O139195EBI-904651,EBI-904686

    Protein-protein interaction databases

    BioGridi276897. 29 interactions.
    DIPiDIP-29339N.
    IntActiO59702. 4 interactions.
    MINTiMINT-4675495.
    STRINGi4896.SPBC36.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni6 – 318313Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225180.
    KOiK06067.
    OMAiHAMRDRA.
    OrthoDBiEOG78M0B2.
    PhylomeDBiO59702.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    O59702-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFGKKKVSY FYDEDVGNYH YGPQHPMKPH RVRMVHNLVV NYNLYEKLNV    50
    ITPVRATRND MTRCHTDEYI EFLWRVTPDT MEKFQPHQLK FNVGDDCPVF 100
    DGLYEFCSIS AGGSIGAAQE LNSGNAEIAI NWAGGLHHAK KREASGFCYV 150
    NDIALAALEL LKYHQRVLYI DIDVHHGDGV EEFFYTTDRV MTCSFHKFGE 200
    YFPGTGHIKD TGIGTGKNYA VNVPLRDGID DESYESVFKP VISHIMQWFR 250
    PEAVILQCGT DSLAGDRLGC FNLSMKGHSM CVDFVKSFNL PMICVGGGGY 300
    TVRNVARVWT YETGLLAGEE LDENLPYNDY LQYYGPDYKL NVLSNNMENH 350
    NTRQYLDSIT SEIIENLRNL SFAPSVQMHK TPGDFTFENA EKQNIAKEEI 400
    MDERV 405
    Length:405
    Mass (Da):46,112
    Last modified:August 1, 1998 - v1
    Checksum:i8EDEA43D5839E367
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064206 Genomic DNA. Translation: AAD05211.1.
    CU329671 Genomic DNA. Translation: CAA19053.1.
    PIRiT40300.
    RefSeqiNP_595333.1. NM_001021241.2.

    Genome annotation databases

    EnsemblFungiiSPBC36.05c.1; SPBC36.05c.1:pep; SPBC36.05c.
    GeneIDi2540368.
    KEGGispo:SPBC36.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064206 Genomic DNA. Translation: AAD05211.1 .
    CU329671 Genomic DNA. Translation: CAA19053.1 .
    PIRi T40300.
    RefSeqi NP_595333.1. NM_001021241.2.

    3D structure databases

    ProteinModelPortali O59702.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276897. 29 interactions.
    DIPi DIP-29339N.
    IntActi O59702. 4 interactions.
    MINTi MINT-4675495.
    STRINGi 4896.SPBC36.05c-1.

    Proteomic databases

    MaxQBi O59702.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC36.05c.1 ; SPBC36.05c.1:pep ; SPBC36.05c .
    GeneIDi 2540368.
    KEGGi spo:SPBC36.05c.

    Organism-specific databases

    PomBasei SPBC36.05c.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225180.
    KOi K06067.
    OMAi HAMRDRA.
    OrthoDBi EOG78M0B2.
    PhylomeDBi O59702.

    Miscellaneous databases

    NextBioi 20801496.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast."
      Grewal S.I.S., Bonaduce M.J., Klar A.J.S.
      Genetics 150:563-576(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity."
      Nakayama J., Xiao G., Noma K., Malikzay A., Bjerling P., Ekwall K., Kobayashi R., Grewal S.I.S.
      EMBO J. 22:2776-2787(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 340-368 AND 381-404, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCLR6_SCHPO
    AccessioniPrimary (citable) accession number: O59702
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3