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Protein

Histone deacetylase clr6

Gene

clr6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation.1 Publication

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138By similarity1

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • histone deacetylation Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of histone H3-K9 methylation Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase clr6 (EC:3.5.1.98)
Alternative name(s):
Cryptic loci regulator 6
Gene namesi
Name:clr6
ORF Names:SPBC36.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC36.05c.
PomBaseiSPBC36.05c. clr6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147401 – 405Histone deacetylase clr6Add BLAST405

Proteomic databases

MaxQBiO59702.
PRIDEiO59702.

Interactioni

Subunit structurei

Heterotetramer of alp13, clr6, prw1 and pst2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
pst2O139195EBI-904651,EBI-904686

Protein-protein interaction databases

BioGridi276897. 36 interactors.
DIPiDIP-29339N.
IntActiO59702. 4 interactors.
MINTiMINT-4675495.
STRINGi4896.SPBC36.05c.1.

Structurei

3D structure databases

ProteinModelPortaliO59702.
SMRiO59702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 318Histone deacetylaseAdd BLAST313

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiO59702.
KOiK06067.
OMAiEFCKISC.
OrthoDBiEOG092C1END.
PhylomeDBiO59702.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

O59702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGKKKVSY FYDEDVGNYH YGPQHPMKPH RVRMVHNLVV NYNLYEKLNV
60 70 80 90 100
ITPVRATRND MTRCHTDEYI EFLWRVTPDT MEKFQPHQLK FNVGDDCPVF
110 120 130 140 150
DGLYEFCSIS AGGSIGAAQE LNSGNAEIAI NWAGGLHHAK KREASGFCYV
160 170 180 190 200
NDIALAALEL LKYHQRVLYI DIDVHHGDGV EEFFYTTDRV MTCSFHKFGE
210 220 230 240 250
YFPGTGHIKD TGIGTGKNYA VNVPLRDGID DESYESVFKP VISHIMQWFR
260 270 280 290 300
PEAVILQCGT DSLAGDRLGC FNLSMKGHSM CVDFVKSFNL PMICVGGGGY
310 320 330 340 350
TVRNVARVWT YETGLLAGEE LDENLPYNDY LQYYGPDYKL NVLSNNMENH
360 370 380 390 400
NTRQYLDSIT SEIIENLRNL SFAPSVQMHK TPGDFTFENA EKQNIAKEEI

MDERV
Length:405
Mass (Da):46,112
Last modified:August 1, 1998 - v1
Checksum:i8EDEA43D5839E367
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064206 Genomic DNA. Translation: AAD05211.1.
CU329671 Genomic DNA. Translation: CAA19053.1.
PIRiT40300.
RefSeqiNP_595333.1. NM_001021241.2.

Genome annotation databases

EnsemblFungiiSPBC36.05c.1; SPBC36.05c.1:pep; SPBC36.05c.
GeneIDi2540368.
KEGGispo:SPBC36.05c.

Similar proteinsi

Entry informationi

Entry nameiCLR6_SCHPO
AccessioniPrimary (citable) accession number: O59702
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: August 1, 1998
Last modified: September 27, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families