Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translation initiation factor IF-2, mitochondrial

Gene

SPBC1271.15c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1858GTPBy similarity
Nucleotide bindingi226 – 2305GTPBy similarity
Nucleotide bindingi280 – 2834GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2, mitochondrial
Short name:
IF-2(Mt)
Short name:
IF-2Mt
Short name:
IF2(mt)
Gene namesi
ORF Names:SPBC1271.15c, SPBC2F6.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1271.15c.
PomBaseiSPBC1271.15c.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 686Translation initiation factor IF-2, mitochondrialPRO_0000014482
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO59683.

Interactioni

Protein-protein interaction databases

MINTiMINT-4675431.

Structurei

3D structure databases

ProteinModelPortaliO59683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 344176tr-type GPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni178 – 1858G1PROSITE-ProRule annotation
Regioni203 – 2075G2PROSITE-ProRule annotation
Regioni226 – 2294G3PROSITE-ProRule annotation
Regioni280 – 2834G4PROSITE-ProRule annotation
Regioni316 – 3183G5PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076906.
InParanoidiO59683.
KOiK02519.
OMAiSTILCFN.
OrthoDBiEOG7SV14K.
PhylomeDBiO59683.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O59683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLSACTSW RHVHNAGFTF ITKFPFVRNV HKLSYHISPL SSRFSLADIS
60 70 80 90 100
VKENNHPNGP QLRLQTHFFH SSSPMHATKG FRFPKSSTPL TLPAVLSVAS
110 120 130 140 150
FANLLQIPTR RILRDLNRLG IKDVFPEYLI TYEYSSLLAE EYGFDVQEAA
160 170 180 190 200
AYSAPSPKSL NSKKDSGPLR PPVVTLMGHV DHGKTTLLDA FRKSTIASTE
210 220 230 240 250
HGGITQKIGA FTVPFDKGSK FITFLDTPGH MAFEAMRKRG ANIADIVVLV
260 270 280 290 300
VAGDDGVKPQ TVEAIKHIQS ADVPVVVALT KSDRPGTPIH KIYEQLLNNG
310 320 330 340 350
IQVEALGGET QIIPISAKTG KGIPELEAAI LTLAEIMEIR ASPRDPFQGW
360 370 380 390 400
IVESSVTKGV GSSATVVVKR GTVKKGMYLV AGKSWCKVRS LVDVNKKSIK
410 420 430 440 450
QVLPGQAAQV YGWKDLPIAG DLAYEVKSES EAKRILSDIY RQSNEQNFYE
460 470 480 490 500
LAESQNEQRV SALAAKKSGP AAIQEETSVS KSFNIIAKCE DTGSMEALSD
510 520 530 540 550
YLKPLQFGKV KSRVLYTGVG PVTETDIERA ETSDAIIISF GVSVPKATFR
560 570 580 590 600
LAEKHNVKLL FHNVIYHLMD DVRKLFALRL PPILVQRVTG EAIISAIFDI
610 620 630 640 650
KAKRAVVHVA GCRVTNGTIE KSHKIRLVRN DKIIWSGEID SLKHLKEEVT
660 670 680
SIKKGRECGI LLKNFDEIVT GDKLQTFVEE YKPPDF
Length:686
Mass (Da):75,611
Last modified:August 1, 1998 - v1
Checksum:i6F5B5CEDC6F3A5CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22205.1.
PIRiT39351.
RefSeqiNP_595135.1. NM_001021043.2.

Genome annotation databases

EnsemblFungiiSPBC1271.15c.1; SPBC1271.15c.1:pep; SPBC1271.15c.
GeneIDi2540181.
KEGGispo:SPBC1271.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22205.1.
PIRiT39351.
RefSeqiNP_595135.1. NM_001021043.2.

3D structure databases

ProteinModelPortaliO59683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4675431.

Proteomic databases

MaxQBiO59683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1271.15c.1; SPBC1271.15c.1:pep; SPBC1271.15c.
GeneIDi2540181.
KEGGispo:SPBC1271.15c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1271.15c.
PomBaseiSPBC1271.15c.

Phylogenomic databases

HOGENOMiHOG000076906.
InParanoidiO59683.
KOiK02519.
OMAiSTILCFN.
OrthoDBiEOG7SV14K.
PhylomeDBiO59683.

Miscellaneous databases

PROiO59683.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiIF2M_SCHPO
AccessioniPrimary (citable) accession number: O59683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.