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Protein

Translation initiation factor IF-2, mitochondrial

Gene

SPBC1271.15c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185GTPBy similarity8
Nucleotide bindingi226 – 230GTPBy similarity5
Nucleotide bindingi280 – 283GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2, mitochondrial
Short name:
IF-2(Mt)
Short name:
IF-2Mt
Short name:
IF2(mt)
Gene namesi
ORF Names:SPBC1271.15c, SPBC2F6.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1271.15c
PomBaseiSPBC1271.15c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000014482? – 686Translation initiation factor IF-2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO59683
PaxDbiO59683
PRIDEiO59683

Interactioni

Protein-protein interaction databases

BioGridi276714, 1 interactor
STRINGi4896.SPBC1271.15c.1

Structurei

3D structure databases

ProteinModelPortaliO59683
SMRiO59683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 344tr-type GPROSITE-ProRule annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 185G1PROSITE-ProRule annotation8
Regioni203 – 207G2PROSITE-ProRule annotation5
Regioni226 – 229G3PROSITE-ProRule annotation4
Regioni280 – 283G4PROSITE-ProRule annotation4
Regioni316 – 318G5PROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076906
InParanoidiO59683
KOiK02519
OMAiDNRTGGY
OrthoDBiEOG092C1PH8
PhylomeDBiO59683

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O59683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLSACTSW RHVHNAGFTF ITKFPFVRNV HKLSYHISPL SSRFSLADIS
60 70 80 90 100
VKENNHPNGP QLRLQTHFFH SSSPMHATKG FRFPKSSTPL TLPAVLSVAS
110 120 130 140 150
FANLLQIPTR RILRDLNRLG IKDVFPEYLI TYEYSSLLAE EYGFDVQEAA
160 170 180 190 200
AYSAPSPKSL NSKKDSGPLR PPVVTLMGHV DHGKTTLLDA FRKSTIASTE
210 220 230 240 250
HGGITQKIGA FTVPFDKGSK FITFLDTPGH MAFEAMRKRG ANIADIVVLV
260 270 280 290 300
VAGDDGVKPQ TVEAIKHIQS ADVPVVVALT KSDRPGTPIH KIYEQLLNNG
310 320 330 340 350
IQVEALGGET QIIPISAKTG KGIPELEAAI LTLAEIMEIR ASPRDPFQGW
360 370 380 390 400
IVESSVTKGV GSSATVVVKR GTVKKGMYLV AGKSWCKVRS LVDVNKKSIK
410 420 430 440 450
QVLPGQAAQV YGWKDLPIAG DLAYEVKSES EAKRILSDIY RQSNEQNFYE
460 470 480 490 500
LAESQNEQRV SALAAKKSGP AAIQEETSVS KSFNIIAKCE DTGSMEALSD
510 520 530 540 550
YLKPLQFGKV KSRVLYTGVG PVTETDIERA ETSDAIIISF GVSVPKATFR
560 570 580 590 600
LAEKHNVKLL FHNVIYHLMD DVRKLFALRL PPILVQRVTG EAIISAIFDI
610 620 630 640 650
KAKRAVVHVA GCRVTNGTIE KSHKIRLVRN DKIIWSGEID SLKHLKEEVT
660 670 680
SIKKGRECGI LLKNFDEIVT GDKLQTFVEE YKPPDF
Length:686
Mass (Da):75,611
Last modified:August 1, 1998 - v1
Checksum:i6F5B5CEDC6F3A5CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22205.1
PIRiT39351
RefSeqiNP_595135.1, NM_001021043.2

Genome annotation databases

EnsemblFungiiSPBC1271.15c.1; SPBC1271.15c.1:pep; SPBC1271.15c
GeneIDi2540181
KEGGispo:SPBC1271.15c

Similar proteinsi

Entry informationi

Entry nameiIF2M_SCHPO
AccessioniPrimary (citable) accession number: O59683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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