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O59682

- LCB1_SCHPO

UniProt

O59682 - LCB1_SCHPO

Protein

Serine palmitoyltransferase 1

Gene

lcb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.By similarity

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.By similarity

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sphingolipid biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_188653. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine palmitoyltransferase 1 (EC:2.3.1.50)
    Short name:
    SPT 1
    Short name:
    SPT1
    Alternative name(s):
    Long chain base biosynthesis protein 1
    Gene namesi
    Name:lcb1By similarity
    ORF Names:SPBC18E5.02c, SPBC29A3.20c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC18E5.02c.

    Subcellular locationi

    Cytoplasm By similaritySequence Analysis. Endoplasmic reticulum 1 Publication. Membrane Sequence Analysis; Multi-pass membrane protein Curated

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. integral component of membrane Source: UniProtKB-KW
    3. serine C-palmitoyltransferase complex Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Serine palmitoyltransferase 1PRO_0000309453Add
    BLAST

    Proteomic databases

    MaxQBiO59682.

    Interactioni

    Subunit structurei

    Lcb1 and lcb2 encode essential subunits of the enzyme and form a heterodimer.By similarity

    Protein-protein interaction databases

    BioGridi277338. 4 interactions.
    MINTiMINT-4675422.
    STRINGi4896.SPBC18E5.02c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO59682.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000216602.
    KOiK00654.
    OMAiVNHQRIN.
    OrthoDBiEOG7XPZG0.
    PhylomeDBiO59682.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O59682-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYSYPFFDD VYAYYNQTVT FFGKALDVLP GSPIVKRYIK SSYQNDPLRT    50
    FIEFLLLVFA AYYVLRKPRT SPDNNYVEFT EKEINELVDD WKPEPLVAEL 100
    TDVEKLELKS IPVLESVHLH TKLIDGRPIT NFASFNFLDL AENKHITECA 150
    VATLRECGLG ACGPPGFYGT QDKHLRLEKD IASFIGVERA IVYAQSFQTI 200
    SSVIPAFSKR GDILVVDEAC NFAIQKGIQI SRTTIRYFKH NNMKDLERIL 250
    QELEDDFVKH NRPLTRRFII TEGISENYGD MVDLTKIVAL KKKYKYRLIL 300
    DETWSFGTCG RTGKGLTEHF GVPPTDVEII IGSLTTSLAG GGGFCAGSEL 350
    MVEHQRLSGM AYIYSAALPA SLAVAAYEAI SILSRDGGSM LNDLRSKSAL 400
    FHAKLSRNKF FETSSDIESP IIHLRFKDKD ISHDKQVFLL EEIVELCIAE 450
    GFLIARAKRV ESLERVKVQP SLRICISTGH SAEEIEKLAL LIKEKTEIVF 500
    DKHKVINQV 509
    Length:509
    Mass (Da):57,469
    Last modified:August 1, 1998 - v1
    Checksum:i26BC0BE6AA6D16A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA18397.1.
    PIRiT39753.
    RefSeqiNP_595848.1. NM_001021752.2.

    Genome annotation databases

    EnsemblFungiiSPBC18E5.02c.1; SPBC18E5.02c.1:pep; SPBC18E5.02c.
    GeneIDi2540820.
    KEGGispo:SPBC18E5.02c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA18397.1 .
    PIRi T39753.
    RefSeqi NP_595848.1. NM_001021752.2.

    3D structure databases

    ProteinModelPortali O59682.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277338. 4 interactions.
    MINTi MINT-4675422.
    STRINGi 4896.SPBC18E5.02c-1.

    Proteomic databases

    MaxQBi O59682.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC18E5.02c.1 ; SPBC18E5.02c.1:pep ; SPBC18E5.02c .
    GeneIDi 2540820.
    KEGGi spo:SPBC18E5.02c.

    Organism-specific databases

    PomBasei SPBC18E5.02c.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000216602.
    KOi K00654.
    OMAi VNHQRIN.
    OrthoDBi EOG7XPZG0.
    PhylomeDBi O59682.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_188653. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    NextBioi 20801937.
    PROi O59682.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLCB1_SCHPO
    AccessioniPrimary (citable) accession number: O59682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3