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O59682

- LCB1_SCHPO

UniProt

O59682 - LCB1_SCHPO

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Protein

Serine palmitoyltransferase 1

Gene

lcb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.By similarity

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sphingolipid biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_188653. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 1 (EC:2.3.1.50)
Short name:
SPT 1
Short name:
SPT1
Alternative name(s):
Long chain base biosynthesis protein 1
Gene namesi
Name:lcb1By similarity
ORF Names:SPBC18E5.02c, SPBC29A3.20c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC18E5.02c.

Subcellular locationi

Cytoplasm By similaritySequence Analysis. Endoplasmic reticulum 1 Publication. Membrane Sequence Analysis; Multi-pass membrane protein Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. integral component of membrane Source: UniProtKB-KW
  3. serine C-palmitoyltransferase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Serine palmitoyltransferase 1PRO_0000309453Add
BLAST

Proteomic databases

MaxQBiO59682.

Interactioni

Subunit structurei

Lcb1 and lcb2 encode essential subunits of the enzyme and form a heterodimer.By similarity

Protein-protein interaction databases

BioGridi277338. 3 interactions.
MINTiMINT-4675422.
STRINGi4896.SPBC18E5.02c-1.

Structurei

3D structure databases

ProteinModelPortaliO59682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000216602.
InParanoidiO59682.
KOiK00654.
OMAiVNHQRIN.
OrthoDBiEOG7XPZG0.
PhylomeDBiO59682.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

O59682-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYSYPFFDD VYAYYNQTVT FFGKALDVLP GSPIVKRYIK SSYQNDPLRT
60 70 80 90 100
FIEFLLLVFA AYYVLRKPRT SPDNNYVEFT EKEINELVDD WKPEPLVAEL
110 120 130 140 150
TDVEKLELKS IPVLESVHLH TKLIDGRPIT NFASFNFLDL AENKHITECA
160 170 180 190 200
VATLRECGLG ACGPPGFYGT QDKHLRLEKD IASFIGVERA IVYAQSFQTI
210 220 230 240 250
SSVIPAFSKR GDILVVDEAC NFAIQKGIQI SRTTIRYFKH NNMKDLERIL
260 270 280 290 300
QELEDDFVKH NRPLTRRFII TEGISENYGD MVDLTKIVAL KKKYKYRLIL
310 320 330 340 350
DETWSFGTCG RTGKGLTEHF GVPPTDVEII IGSLTTSLAG GGGFCAGSEL
360 370 380 390 400
MVEHQRLSGM AYIYSAALPA SLAVAAYEAI SILSRDGGSM LNDLRSKSAL
410 420 430 440 450
FHAKLSRNKF FETSSDIESP IIHLRFKDKD ISHDKQVFLL EEIVELCIAE
460 470 480 490 500
GFLIARAKRV ESLERVKVQP SLRICISTGH SAEEIEKLAL LIKEKTEIVF

DKHKVINQV
Length:509
Mass (Da):57,469
Last modified:August 1, 1998 - v1
Checksum:i26BC0BE6AA6D16A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18397.1.
PIRiT39753.
RefSeqiNP_595848.1. NM_001021752.2.

Genome annotation databases

EnsemblFungiiSPBC18E5.02c.1; SPBC18E5.02c.1:pep; SPBC18E5.02c.
GeneIDi2540820.
KEGGispo:SPBC18E5.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18397.1 .
PIRi T39753.
RefSeqi NP_595848.1. NM_001021752.2.

3D structure databases

ProteinModelPortali O59682.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277338. 3 interactions.
MINTi MINT-4675422.
STRINGi 4896.SPBC18E5.02c-1.

Proteomic databases

MaxQBi O59682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC18E5.02c.1 ; SPBC18E5.02c.1:pep ; SPBC18E5.02c .
GeneIDi 2540820.
KEGGi spo:SPBC18E5.02c.

Organism-specific databases

PomBasei SPBC18E5.02c.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000216602.
InParanoidi O59682.
KOi K00654.
OMAi VNHQRIN.
OrthoDBi EOG7XPZG0.
PhylomeDBi O59682.

Enzyme and pathway databases

UniPathwayi UPA00222 .
Reactomei REACT_188653. Sphingolipid de novo biosynthesis.

Miscellaneous databases

NextBioi 20801937.
PROi O59682.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLCB1_SCHPO
AccessioniPrimary (citable) accession number: O59682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3