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Protein

PWWP domain-containing protein 1

Gene

pdp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: PomBase
  • H4K20me3 modified histone binding Source: PomBase
  • histone binding Source: PomBase
  • methylated histone binding Source: PomBase
  • nucleosomal DNA binding Source: PomBase
  • nucleosomal histone binding Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein 1
Alternative name(s):
Set9-associated factor pdp1
Gene namesi
Name:pdp1
ORF Names:SPBC29A3.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC29A3.13
PomBaseiSPBC29A3.13 pdp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi66W → A: Reduces the association of set9 with nucleosome and the H4K20me3 levels. 1 Publication1
Mutagenesisi94F → A: Reduces the association of set9 with nucleosome and the H4K20me3 levels. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003039501 – 359PWWP domain-containing protein 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO59676
PaxDbiO59676
PRIDEiO59676

PTM databases

iPTMnetiO59676

Interactioni

Subunit structurei

Interacts with set9 and histone H4K20me1. Associates with nucleosomes.1 Publication

GO - Molecular functioni

  • H4K20me3 modified histone binding Source: PomBase
  • histone binding Source: PomBase
  • methylated histone binding Source: PomBase
  • nucleosomal histone binding Source: PomBase

Protein-protein interaction databases

BioGridi276883, 48 interactors
STRINGi4896.SPBC29A3.13.1

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi54 – 59Combined sources6
Beta strandi61 – 63Combined sources3
Beta strandi65 – 80Combined sources16
Beta strandi82 – 84Combined sources3
Beta strandi86 – 94Combined sources9
Turni95 – 98Combined sources4
Beta strandi99 – 103Combined sources5
Helixi105 – 107Combined sources3
Beta strandi108 – 110Combined sources3
Helixi113 – 121Combined sources9
Beta strandi123 – 125Combined sources3
Helixi128 – 137Combined sources10
Helixi140 – 142Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L89NMR-A45-152[»]
ProteinModelPortaliO59676
SMRiO59676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 114PWWPPROSITE-ProRule annotationAdd BLAST63

Domaini

The C-terminal region mediates association with set9, whereas the N-terminal PWWP domain recognizes H4K20me1.1 Publication

Phylogenomic databases

InParanoidiO59676
OMAiWPAVVFP
OrthoDBiEOG092C48L5
PhylomeDBiO59676

Family and domain databases

CDDicd05840 SPBC215_ISWI_like, 1 hit
InterProiView protein in InterPro
IPR035503 IOC4-like_PWWP
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequencei

Sequence statusi: Complete.

O59676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNARTNAKR RRLSSKQGGL SISEGKESNI PSVVEESKDN LEQASADDRL
60 70 80 90 100
NFGDRILVKA PGYPWWPALL LRRKETKDSL NTNSSFNVLY KVLFFPDFNF
110 120 130 140 150
AWVKRNSVKP LLDSEIAKFL GSSKRKSKEL IEAYEASKTP PDLKEESSTD
160 170 180 190 200
EEMDSLSAAE EKPNFLQKRK YHWETSLDES DAESISSGSL MSITSISEMY
210 220 230 240 250
GPTVASTSRS STQLSDQRYP LSSNFDHRGE AKGKGKQPLK NPQERGRISP
260 270 280 290 300
SSPLNDQTKA LMQRLLFFRH KLQKAFLSPD HLIVEEDFYN ASKYLNAISD
310 320 330 340 350
IPFLNYELIT STKLAKVLKR IAFLEHLEND ELYDIRQKCK NLLYSWAMFL

PNEPSIKGM
Length:359
Mass (Da):40,923
Last modified:August 1, 1998 - v1
Checksum:iA892EE06E5F7DB2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18390.1
AB027814 Genomic DNA Translation: BAA87118.1
PIRiT40084
RefSeqiNP_595841.1, NM_001021745.2

Genome annotation databases

EnsemblFungiiSPBC29A3.13.1; SPBC29A3.13.1:pep; SPBC29A3.13
GeneIDi2540354
KEGGispo:SPBC29A3.13

Entry informationi

Entry nameiPDP1_SCHPO
AccessioniPrimary (citable) accession number: O59676
Secondary accession number(s): Q9USE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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