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Protein

Copper-transporting ATPase ccc2

Gene

ccc2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone atx1 and incorporates it into trans-Golgi vesicles (By similarity).By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13CopperPROSITE-ProRule annotation1
Metal bindingi16CopperPROSITE-ProRule annotation1
Active sitei5294-aspartylphosphate intermediateBy similarity1
Metal bindingi742MagnesiumPROSITE-ProRule annotation1
Metal bindingi746MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: PomBase
  • copper ion export Source: PomBase

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.5.29 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase ccc2 (EC:3.6.3.54)
Alternative name(s):
Cu(2+)-ATPase
Gene namesi
Name:ccc2
ORF Names:SPBC29A3.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC29A3.01
PomBaseiSPBC29A3.01 ccc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 172CytoplasmicBy similarityAdd BLAST172
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 197Lumenal, vesicleBy similarity4
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 246CytoplasmicBy similarityAdd BLAST28
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 278Lumenal, vesicleBy similarityAdd BLAST11
Transmembranei279 – 296HelicalSequence analysisAdd BLAST18
Topological domaini297 – 431CytoplasmicBy similarityAdd BLAST135
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 469Lumenal, vesicleBy similarityAdd BLAST17
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 805CytoplasmicBy similarityAdd BLAST315
Transmembranei806 – 826HelicalSequence analysisAdd BLAST21
Topological domaini827 – 828Lumenal, vesicleBy similarity2
Transmembranei829 – 849HelicalSequence analysisAdd BLAST21
Topological domaini850 – 904CytoplasmicBy similarityAdd BLAST55

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147531 – 904Copper-transporting ATPase ccc2Add BLAST904

Proteomic databases

MaxQBiO59666
PaxDbiO59666
PRIDEiO59666

PTM databases

iPTMnetiO59666

Interactioni

Protein-protein interaction databases

BioGridi277053, 2 interactors
STRINGi4896.SPBC29A3.01.1

Structurei

3D structure databases

ProteinModelPortaliO59666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 69HMAPROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi480 – 483Poly-Val4
Compositional biasi645 – 648Poly-Ser4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397
InParanoidiO59666
KOiK17686
OMAiHIFGGPL
OrthoDBiEOG092C0DN9
PhylomeDBiO59666

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O59666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTTTLSVQG MTCTSCVASI QSMLEGVEGI EQFTISLLLE RAIAVHDPSI
60 70 80 90 100
ISPDQIAEKI EDCGFDASVI SSTEGEHGVM ANYLLLSPMQ AEQWTKVHNH
110 120 130 140 150
INELQGVLSV NCSSSPDAAI RVIYDSEITG PRSIMKEILS MGVKCTFQPV
160 170 180 190 200
DSSTSRILSL QRGSQIRVWK IRFIISISFS LAVMFLPQIF DSCDSMRAAF
210 220 230 240 250
LVPHYFGICA GHIISLVLSL PVQFGVGRVY YSAAYHALKR GTANMDVLVS
260 270 280 290 300
LGSTVAFAAS IFFMILYSAR HADNPAPIFF DTADMLLTFV TLGRYLESKA
310 320 330 340 350
KGSTSAALSQ LLSLAPSSAT IIEDNEQIEI LADLIERGDL ILVKPGEIIP
360 370 380 390 400
VDGTVVEGSS YVDESSVSGE PVPVHKTIDD ELLSGTANGN GRLLVKATKS
410 420 430 440 450
PRESQLAVIV DLVQRAQISH APIQQFADRV AGIFVPVIVA LSISTFTFWF
460 470 480 490 500
LFTKYSSKYP SVFDDPMGKF AVCLKLTISV VVVACPCALG LSTPTAVMVG
510 520 530 540 550
TGVGALNGII IKGGEILERL NQVDTVVFDK TGTLTVGKLS VTDISIVDNL
560 570 580 590 600
EELLDIPKNI FWAFVKASES SSEHPIGKAI TEKASEFTDV SEIGIESFNA
610 620 630 640 650
VPGEGVDVVL RWKERTFHAL LGNSLLLEHN NVSIPDDFDS KLKLSSSSGL
660 670 680 690 700
TCVRIAIDGQ FVGFLGCMDQ VRPDSYQTVS ALKQLGKKVC LLTGDQKATA
710 720 730 740 750
RRVAQGLEID FSDVYAEAVP SQKAEIIQKL KDQKHCVAMV GDGINDSPSL
760 770 780 790 800
VLADVGIAPI NGSGIALESA DVILVRKGVL LDTAVSFDLS RVIVKRIKMN
810 820 830 840 850
LVWACIYNFV MIPIAMGFFL PWGIYLNPMW ASAAMMFSSL SVLASSLLLR
860 870 880 890 900
RWKKPKSLIF SEADDVETES STNSSVLQKV YTATRSIFGR NKSSNKYQPV

ANEV
Length:904
Mass (Da):97,895
Last modified:August 1, 1998 - v1
Checksum:i546EE3C8AAECE146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18378.1
PIRiT40072
RefSeqiNP_595829.1, NM_001021733.2

Genome annotation databases

EnsemblFungiiSPBC29A3.01.1; SPBC29A3.01.1:pep; SPBC29A3.01
GeneIDi2540525
KEGGispo:SPBC29A3.01

Similar proteinsi

Entry informationi

Entry nameiATU2_SCHPO
AccessioniPrimary (citable) accession number: O59666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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