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Protein

Glutamine synthetase

Gene

glnA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-1237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:MMP1206
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Glutamine synthetasePRO_0000153205Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP1206.

Structurei

3D structure databases

ProteinModelPortaliO59648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiFGEGTYA.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVEQAMEY IKTNNVKFIR FQFVDIHGEP KNIAYPVKAG AAGEEELYDV
60 70 80 90 100
LEKGVYFDGS SIEGFVSIES SDMMLKPDLK TLSVLPWRPT EKSVARVICD
110 120 130 140 150
VYTTNGKPFE GDPRGCLKRV LAKFDEELGG EFFVGPEPEF FILKEDACGS
160 170 180 190 200
WVPADDAGYF DLEPLDGGCD IRRKIVFALE NLGFHVEASH HEVAEGQHEV
210 220 230 240 250
DFKFADAVKT ADSVVTFKTT IKTLAAQDGL KATFMPKPFF GINGSGMHCH
260 270 280 290 300
QSIWLNGEPS FYDESAQYQL SETCMSYVAG ILDHAKSIVA VTNPTVNSYK
310 320 330 340 350
RLVPGYEAPV NIAWANSNRS AIVRVPAPRG KGTRIEFRAP DPACNPYLAF
360 370 380 390 400
TVMLAAGLDG VKRKLSAIEP VEKNIFAMSE AQKKAEGIES VPANLKAALD
410 420 430 440
ELENNSVLKD ALGKHIFENF IEIKNAEWDS FRTAVTDWET KQYLKI
Length:446
Mass (Da):49,421
Last modified:August 1, 1998 - v1
Checksum:iDDE984106651122A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062391 Genomic DNA. Translation: AAD04845.1.
BX950229 Genomic DNA. Translation: CAF30762.1.
RefSeqiNP_988326.1. NC_005791.1.
WP_011171150.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF30762; CAF30762; MMP1206.
GeneIDi2761968.
KEGGimmp:MMP1206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062391 Genomic DNA. Translation: AAD04845.1.
BX950229 Genomic DNA. Translation: CAF30762.1.
RefSeqiNP_988326.1. NC_005791.1.
WP_011171150.1. NC_005791.1.

3D structure databases

ProteinModelPortaliO59648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267377.MMP1206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF30762; CAF30762; MMP1206.
GeneIDi2761968.
KEGGimmp:MMP1206.

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiFGEGTYA.

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-1237-MONOMER.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Function and regulation of glnA in the methanogenic archaeon Methanococcus maripaludis."
    Cohen-Kupiec R., Marx C.J., Leigh J.A.
    J. Bacteriol. 181:256-261(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S2 / LL.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiGLNA_METMP
AccessioniPrimary (citable) accession number: O59648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.