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O59648 (GLNA_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

Short name=GS
EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:MMP1206
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the glutamine synthetase family.

Caution

Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Glutamine synthetase
PRO_0000153205

Sequences

Sequence LengthMass (Da)Tools
O59648 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: DDE984106651122A

FASTA44649,421
        10         20         30         40         50         60 
MNAVEQAMEY IKTNNVKFIR FQFVDIHGEP KNIAYPVKAG AAGEEELYDV LEKGVYFDGS 

        70         80         90        100        110        120 
SIEGFVSIES SDMMLKPDLK TLSVLPWRPT EKSVARVICD VYTTNGKPFE GDPRGCLKRV 

       130        140        150        160        170        180 
LAKFDEELGG EFFVGPEPEF FILKEDACGS WVPADDAGYF DLEPLDGGCD IRRKIVFALE 

       190        200        210        220        230        240 
NLGFHVEASH HEVAEGQHEV DFKFADAVKT ADSVVTFKTT IKTLAAQDGL KATFMPKPFF 

       250        260        270        280        290        300 
GINGSGMHCH QSIWLNGEPS FYDESAQYQL SETCMSYVAG ILDHAKSIVA VTNPTVNSYK 

       310        320        330        340        350        360 
RLVPGYEAPV NIAWANSNRS AIVRVPAPRG KGTRIEFRAP DPACNPYLAF TVMLAAGLDG 

       370        380        390        400        410        420 
VKRKLSAIEP VEKNIFAMSE AQKKAEGIES VPANLKAALD ELENNSVLKD ALGKHIFENF 

       430        440 
IEIKNAEWDS FRTAVTDWET KQYLKI 

« Hide

References

« Hide 'large scale' references
[1]"Function and regulation of glnA in the methanogenic archaeon Methanococcus maripaludis."
Cohen-Kupiec R., Marx C.J., Leigh J.A.
J. Bacteriol. 181:256-261(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S2 / LL.
[2]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF062391 Genomic DNA. Translation: AAD04845.1.
BX950229 Genomic DNA. Translation: CAF30762.1.
RefSeqNP_988326.1. NC_005791.1.

3D structure databases

ProteinModelPortalO59648.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267377.MMP1206.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF30762; CAF30762; MMP1206.
GeneID2761968.
KEGGmmp:MMP1206.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0174.
HOGENOMHOG000005156.
KOK01915.
OMAIEWDMFR.

Enzyme and pathway databases

BioCycMMAR267377:GJ77-1237-MONOMER.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_METMP
AccessionPrimary (citable) accession number: O59648
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families