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O59648

- GLNA_METMP

UniProt

O59648 - GLNA_METMP

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Protein

Glutamine synthetase

Gene

glnA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-1237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:MMP1206
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Glutamine synthetasePRO_0000153205Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP1206.

Structurei

3D structure databases

ProteinModelPortaliO59648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiIEWDMFR.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59648-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAVEQAMEY IKTNNVKFIR FQFVDIHGEP KNIAYPVKAG AAGEEELYDV
60 70 80 90 100
LEKGVYFDGS SIEGFVSIES SDMMLKPDLK TLSVLPWRPT EKSVARVICD
110 120 130 140 150
VYTTNGKPFE GDPRGCLKRV LAKFDEELGG EFFVGPEPEF FILKEDACGS
160 170 180 190 200
WVPADDAGYF DLEPLDGGCD IRRKIVFALE NLGFHVEASH HEVAEGQHEV
210 220 230 240 250
DFKFADAVKT ADSVVTFKTT IKTLAAQDGL KATFMPKPFF GINGSGMHCH
260 270 280 290 300
QSIWLNGEPS FYDESAQYQL SETCMSYVAG ILDHAKSIVA VTNPTVNSYK
310 320 330 340 350
RLVPGYEAPV NIAWANSNRS AIVRVPAPRG KGTRIEFRAP DPACNPYLAF
360 370 380 390 400
TVMLAAGLDG VKRKLSAIEP VEKNIFAMSE AQKKAEGIES VPANLKAALD
410 420 430 440
ELENNSVLKD ALGKHIFENF IEIKNAEWDS FRTAVTDWET KQYLKI
Length:446
Mass (Da):49,421
Last modified:August 1, 1998 - v1
Checksum:iDDE984106651122A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF062391 Genomic DNA. Translation: AAD04845.1.
BX950229 Genomic DNA. Translation: CAF30762.1.
RefSeqiNP_988326.1. NC_005791.1.
WP_011171150.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF30762; CAF30762; MMP1206.
GeneIDi2761968.
KEGGimmp:MMP1206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF062391 Genomic DNA. Translation: AAD04845.1 .
BX950229 Genomic DNA. Translation: CAF30762.1 .
RefSeqi NP_988326.1. NC_005791.1.
WP_011171150.1. NC_005791.1.

3D structure databases

ProteinModelPortali O59648.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267377.MMP1206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF30762 ; CAF30762 ; MMP1206 .
GeneIDi 2761968.
KEGGi mmp:MMP1206.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005156.
KOi K01915.
OMAi IEWDMFR.

Enzyme and pathway databases

BioCyci MMAR267377:GJ77-1237-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Function and regulation of glnA in the methanogenic archaeon Methanococcus maripaludis."
    Cohen-Kupiec R., Marx C.J., Leigh J.A.
    J. Bacteriol. 181:256-261(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S2 / LL.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiGLNA_METMP
AccessioniPrimary (citable) accession number: O59648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3