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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170GTPUniRule annotation1
Binding sitei174GTPUniRule annotation1
Binding sitei217GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 56GTPUniRule annotation5
Nucleotide bindingi139 – 141GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Ta0072
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144171 – 395Cell division protein FtsZAdd BLAST395

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta0072

Structurei

3D structure databases

ProteinModelPortaliO59635
SMRiO59635
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

O59635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDITDLLSK VSIDDVYDEW EDQASGSLPE DAEIENVYKT LNVKIKVIGC
60 70 80 90 100
GGGGSNTVNR LYDDALKNAD LIAINTDASH LRSIKVKHKL LIGQKTTKGL
110 120 130 140 150
GTGADPKVGE EAAIEEIVAI KKIVQNTDIT FVTAGLGGGT GTGCAPVIAR
160 170 180 190 200
AAKEAGSIVI SVVTLPFESE GPLRMDNAVI GLEKLAQFSD TLVAIPNQKL
210 220 230 240 250
LSEVPNAEMK VAFAYADKVL ADTIRSIVEI ITKTGIINID YSDIKTVMQS
260 270 280 290 300
GGVALIGMGQ SKKGGDRIMT ALEEALKPRL IDVDVSTAKD CVFKIIAPPD
310 320 330 340 350
ITVSEVGKAM DEIKKKINPR SRIIWGLTID KDLDKDVKVL IFMTGVSSAY
360 370 380 390
LVKDVESARK AGEHVHRIIC GRDRHGELDQ PMIRENIFFN LIITT
Length:395
Mass (Da):42,526
Last modified:August 1, 1998 - v1
Checksum:i9211322158445E10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199K → R in CAC11220 (PubMed:11029001).Curated1
Sequence conflicti361 – 395AGEHV…LIITT → LASMFTGSYAAEIDTVN in CAC11220 (PubMed:11029001).CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038845 Genomic DNA Translation: AAC24043.1
AL445063 Genomic DNA Translation: CAC11220.1
PIRiT37331
RefSeqiWP_010900500.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC11220; CAC11220; CAC11220
GeneIDi1455732
KEGGitac:Ta0072

Similar proteinsi

Entry informationi

Entry nameiFTSZ_THEAC
AccessioniPrimary (citable) accession number: O59635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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