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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NADBy similarity
Binding sitei159 – 1591NADBy similarity
Binding sitei181 – 1811NADBy similarity
Binding sitei204 – 2041SubstrateBy similarity
Metal bindingi226 – 2261ZincBy similarity
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi229 – 2291ZincBy similarity
Binding sitei229 – 2291SubstrateBy similarity
Active sitei274 – 2741Proton acceptorBy similarity
Active sitei275 – 2751Proton acceptorBy similarity
Binding sitei275 – 2751SubstrateBy similarity
Metal bindingi308 – 3081ZincBy similarity
Binding sitei308 – 3081SubstrateBy similarity
Binding sitei362 – 3621SubstrateBy similarity
Metal bindingi367 – 3671ZincBy similarity
Binding sitei367 – 3671SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PF1659
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Histidinol dehydrogenasePRO_0000135903Add
BLAST

Proteomic databases

PRIDEiO59626.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1659.

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWVVAAKR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEEYVREI LKDIRERGLE AIREYSKKFD GYEGPFEVSK EEFKEAEERI
60 70 80 90 100
PERDKEIIKR TLKRIEKYHR KQLKQDILYI ENGSLYGLIY KPLKRIGIYV
110 120 130 140 150
PGGKPLPSTL MMVGVPARVA GVKEIVVTNP PKDGKVNPYI LYIAKLLKIE
160 170 180 190 200
EVYKLGGIQA IAAMAYGIGM KKVQKIFGPG NKFVNEAKRQ VFGIVGIDSL
210 220 230 240 250
AGPSEIAVIA DESADKDFVL YDLLSQLEHG KDSKAWLLTT SKELADYCNR
260 270 280 290 300
EGITVIVCSS LEECCKKANE IAPEHLEIIT REPLKLVDLI ENAGAIYLGL
310 320 330 340 350
YTPVPAADYF LGVNHVLPTG GAAKFMGVLT VWDFMKPISI AMVSREEFIS
360 370
ERELGIRLAE IEGIELHKKS LEVRK
Length:375
Mass (Da):42,178
Last modified:April 3, 2002 - v2
Checksum:iF8874116A40B1A1B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971G → R in BAA25804 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013080 Genomic DNA. Translation: BAA25804.1.
AE009950 Genomic DNA. Translation: AAL81783.1.
RefSeqiNP_579388.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81783; AAL81783; PF1659.
GeneIDi1469536.
KEGGipfu:PF1659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013080 Genomic DNA. Translation: BAA25804.1.
AE009950 Genomic DNA. Translation: AAL81783.1.
RefSeqiNP_579388.1. NC_003413.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1659.

Proteomic databases

PRIDEiO59626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81783; AAL81783; PF1659.
GeneIDi1469536.
KEGGipfu:PF1659.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWVVAAKR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kanai A., Oida H., Hasegawa A., Doi H.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiHISX_PYRFU
AccessioniPrimary (citable) accession number: O59626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 3, 2002
Last modified: April 1, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.