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O59626

- HISX_PYRFU

UniProt

O59626 - HISX_PYRFU

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (03 Apr 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991NADBy similarity
    Binding sitei159 – 1591NADBy similarity
    Binding sitei181 – 1811NADBy similarity
    Binding sitei204 – 2041SubstrateBy similarity
    Metal bindingi226 – 2261ZincBy similarity
    Binding sitei226 – 2261SubstrateBy similarity
    Metal bindingi229 – 2291ZincBy similarity
    Binding sitei229 – 2291SubstrateBy similarity
    Active sitei274 – 2741Proton acceptorBy similarity
    Active sitei275 – 2751Proton acceptorBy similarity
    Binding sitei275 – 2751SubstrateBy similarity
    Metal bindingi308 – 3081ZincBy similarity
    Binding sitei308 – 3081SubstrateBy similarity
    Binding sitei362 – 3621SubstrateBy similarity
    Metal bindingi367 – 3671ZincBy similarity
    Binding sitei367 – 3671SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:PF1659
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Histidinol dehydrogenasePRO_0000135903Add
    BLAST

    Proteomic databases

    PRIDEiO59626.

    Interactioni

    Protein-protein interaction databases

    STRINGi186497.PF1659.

    Structurei

    3D structure databases

    ProteinModelPortaliO59626.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiNAMSILL.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 2 hits.
    [Graphical view]
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIEEYVREI LKDIRERGLE AIREYSKKFD GYEGPFEVSK EEFKEAEERI    50
    PERDKEIIKR TLKRIEKYHR KQLKQDILYI ENGSLYGLIY KPLKRIGIYV 100
    PGGKPLPSTL MMVGVPARVA GVKEIVVTNP PKDGKVNPYI LYIAKLLKIE 150
    EVYKLGGIQA IAAMAYGIGM KKVQKIFGPG NKFVNEAKRQ VFGIVGIDSL 200
    AGPSEIAVIA DESADKDFVL YDLLSQLEHG KDSKAWLLTT SKELADYCNR 250
    EGITVIVCSS LEECCKKANE IAPEHLEIIT REPLKLVDLI ENAGAIYLGL 300
    YTPVPAADYF LGVNHVLPTG GAAKFMGVLT VWDFMKPISI AMVSREEFIS 350
    ERELGIRLAE IEGIELHKKS LEVRK 375
    Length:375
    Mass (Da):42,178
    Last modified:April 3, 2002 - v2
    Checksum:iF8874116A40B1A1B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971G → R in BAA25804. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013080 Genomic DNA. Translation: BAA25804.1.
    AE009950 Genomic DNA. Translation: AAL81783.1.
    RefSeqiNP_579388.1. NC_003413.1.
    WP_011012805.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL81783; AAL81783; PF1659.
    GeneIDi1469536.
    KEGGipfu:PF1659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013080 Genomic DNA. Translation: BAA25804.1 .
    AE009950 Genomic DNA. Translation: AAL81783.1 .
    RefSeqi NP_579388.1. NC_003413.1.
    WP_011012805.1. NC_003413.1.

    3D structure databases

    ProteinModelPortali O59626.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF1659.

    Proteomic databases

    PRIDEi O59626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL81783 ; AAL81783 ; PF1659 .
    GeneIDi 1469536.
    KEGGi pfu:PF1659.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi NAMSILL.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 2 hits.
    [Graphical view ]
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kanai A., Oida H., Hasegawa A., Doi H.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
    2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiHISX_PYRFU
    AccessioniPrimary (citable) accession number: O59626
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: April 3, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3