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O59626

- HISX_PYRFU

UniProt

O59626 - HISX_PYRFU

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Protein
Histidinol dehydrogenase
Gene
hisD, PF1659
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NAD By similarity
Binding sitei159 – 1591NAD By similarity
Binding sitei181 – 1811NAD By similarity
Binding sitei204 – 2041Substrate By similarity
Metal bindingi226 – 2261Zinc By similarity
Binding sitei226 – 2261Substrate By similarity
Metal bindingi229 – 2291Zinc By similarity
Binding sitei229 – 2291Substrate By similarity
Active sitei274 – 2741Proton acceptor By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei275 – 2751Substrate By similarity
Metal bindingi308 – 3081Zinc By similarity
Binding sitei308 – 3081Substrate By similarity
Binding sitei362 – 3621Substrate By similarity
Metal bindingi367 – 3671Zinc By similarity
Binding sitei367 – 3671Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PF1659
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Histidinol dehydrogenaseUniRule annotation
PRO_0000135903Add
BLAST

Proteomic databases

PRIDEiO59626.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1659.

Structurei

3D structure databases

ProteinModelPortaliO59626.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59626-1 [UniParc]FASTAAdd to Basket

« Hide

MDIEEYVREI LKDIRERGLE AIREYSKKFD GYEGPFEVSK EEFKEAEERI    50
PERDKEIIKR TLKRIEKYHR KQLKQDILYI ENGSLYGLIY KPLKRIGIYV 100
PGGKPLPSTL MMVGVPARVA GVKEIVVTNP PKDGKVNPYI LYIAKLLKIE 150
EVYKLGGIQA IAAMAYGIGM KKVQKIFGPG NKFVNEAKRQ VFGIVGIDSL 200
AGPSEIAVIA DESADKDFVL YDLLSQLEHG KDSKAWLLTT SKELADYCNR 250
EGITVIVCSS LEECCKKANE IAPEHLEIIT REPLKLVDLI ENAGAIYLGL 300
YTPVPAADYF LGVNHVLPTG GAAKFMGVLT VWDFMKPISI AMVSREEFIS 350
ERELGIRLAE IEGIELHKKS LEVRK 375
Length:375
Mass (Da):42,178
Last modified:April 3, 2002 - v2
Checksum:iF8874116A40B1A1B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971G → R in BAA25804. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013080 Genomic DNA. Translation: BAA25804.1.
AE009950 Genomic DNA. Translation: AAL81783.1.
RefSeqiNP_579388.1. NC_003413.1.
WP_011012805.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81783; AAL81783; PF1659.
GeneIDi1469536.
KEGGipfu:PF1659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013080 Genomic DNA. Translation: BAA25804.1 .
AE009950 Genomic DNA. Translation: AAL81783.1 .
RefSeqi NP_579388.1. NC_003413.1.
WP_011012805.1. NC_003413.1.

3D structure databases

ProteinModelPortali O59626.
ModBasei Search...

Protein-protein interaction databases

STRINGi 186497.PF1659.

Proteomic databases

PRIDEi O59626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL81783 ; AAL81783 ; PF1659 .
GeneIDi 1469536.
KEGGi pfu:PF1659.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 2 hits.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kanai A., Oida H., Hasegawa A., Doi H.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiHISX_PYRFU
AccessioniPrimary (citable) accession number: O59626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 3, 2002
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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