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Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881IronBy similarity
Metal bindingi90 – 901IronBy similarity
Metal bindingi97 – 971IronBy similarity
Metal bindingi136 – 1361IronBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1962-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgiA
Ordered Locus Names:PH1956
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Glucose-6-phosphate isomerasePRO_0000185358Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1956.

Structurei

3D structure databases

ProteinModelPortaliO59618.
SMRiO59618. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.Curated

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR016758. G6P_isomerase_archaea/bacteria.
IPR010551. G6P_isomerase_prok.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

O59618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKEPLGVKV DFESGVIEGA KKLVRRLSDM KGYFLDEETW RELVEREDPV
60 70 80 90 100
VYEVYAVEQE EKEGDLNFAT TVLYPGKVGK EFFFTKGHFH AKRDRAEVYI
110 120 130 140 150
ALKGKGGMLL QTPEGEARWI PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA
160 170 180
IYPADAGHDY GTIAEKGFSK IVIEENGEVK VVDNPRWKN
Length:189
Mass (Da):21,596
Last modified:November 8, 2002 - v2
Checksum:iD7424F200F378C4F
GO

Sequence cautioni

The sequence BAA31083.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA31083.1. Different initiation.
PIRiD71211.
RefSeqiNP_143784.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA31083; BAA31083; BAA31083.
GeneIDi1442804.
KEGGipho:PH1956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA31083.1. Different initiation.
PIRiD71211.
RefSeqiNP_143784.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO59618.
SMRiO59618. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA31083; BAA31083; BAA31083.
GeneIDi1442804.
KEGGipho:PH1956.

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciPHOR70601:GJWR-1962-MONOMER.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR016758. G6P_isomerase_archaea/bacteria.
IPR010551. G6P_isomerase_prok.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiG6PI_PYRHO
AccessioniPrimary (citable) accession number: O59618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: April 1, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.