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Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgiA)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88IronBy similarity1
Metal bindingi90IronBy similarity1
Metal bindingi97IronBy similarity1
Metal bindingi136IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1897-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgiA
Ordered Locus Names:PH1956
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853581 – 189Glucose-6-phosphate isomeraseAdd BLAST189

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1956

Structurei

3D structure databases

ProteinModelPortaliO59618
SMRiO59618
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.Curated

Phylogenomic databases

eggNOGiarCOG02602 Archaea
COG2140 LUCA
HOGENOMiHOG000243903
KOiK06859
OMAiYPADAGH
OrthoDBiPOG093Z0BUP

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_01410 G6P_isomerase_arch, 1 hit
InterProiView protein in InterPro
IPR016758 G6P_isomerase_archaea/bacteria
IPR010551 G6P_isomerase_prok
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF06560 GPI, 1 hit
PIRSFiPIRSF019325 Glucose-6-phosphate_isomerase, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

O59618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKEPLGVKV DFESGVIEGA KKLVRRLSDM KGYFLDEETW RELVEREDPV
60 70 80 90 100
VYEVYAVEQE EKEGDLNFAT TVLYPGKVGK EFFFTKGHFH AKRDRAEVYI
110 120 130 140 150
ALKGKGGMLL QTPEGEARWI PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA
160 170 180
IYPADAGHDY GTIAEKGFSK IVIEENGEVK VVDNPRWKN
Length:189
Mass (Da):21,596
Last modified:November 8, 2002 - v2
Checksum:iD7424F200F378C4F
GO

Sequence cautioni

The sequence BAA31083 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA31083.1 Different initiation.
PIRiD71211
RefSeqiWP_048053524.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA31083; BAA31083; BAA31083
GeneIDi1442804
KEGGipho:PH1956

Similar proteinsi

Entry informationi

Entry nameiG6PI_PYRHO
AccessioniPrimary (citable) accession number: O59618
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: April 25, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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