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O59618

- G6PI_PYRHO

UniProt

O59618 - G6PI_PYRHO

Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (08 Nov 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881IronBy similarity
    Metal bindingi90 – 901IronBy similarity
    Metal bindingi97 – 971IronBy similarity
    Metal bindingi136 – 1361IronBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-1962-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgiA
    Ordered Locus Names:PH1956
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Glucose-6-phosphate isomerasePRO_0000185358Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi70601.PH1956.

    Structurei

    3D structure databases

    ProteinModelPortaliO59618.
    SMRiO59618. Positions 1-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal-type GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG2140.
    HOGENOMiHOG000243903.
    KOiK06859.
    OMAiYPADAGH.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    HAMAPiMF_01410. G6P_isomerase_arch.
    InterProiIPR010551. G6P_isomerase_prok.
    IPR016758. G6P_isomerase_subgr.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF06560. GPI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O59618-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKEPLGVKV DFESGVIEGA KKLVRRLSDM KGYFLDEETW RELVEREDPV    50
    VYEVYAVEQE EKEGDLNFAT TVLYPGKVGK EFFFTKGHFH AKRDRAEVYI 100
    ALKGKGGMLL QTPEGEARWI PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA 150
    IYPADAGHDY GTIAEKGFSK IVIEENGEVK VVDNPRWKN 189
    Length:189
    Mass (Da):21,596
    Last modified:November 8, 2002 - v2
    Checksum:iD7424F200F378C4F
    GO

    Sequence cautioni

    The sequence BAA31083.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA31083.1. Different initiation.
    PIRiD71211.
    RefSeqiNP_143784.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA31083; BAA31083; BAA31083.
    GeneIDi1442804.
    KEGGipho:PH1956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA31083.1 . Different initiation.
    PIRi D71211.
    RefSeqi NP_143784.1. NC_000961.1.

    3D structure databases

    ProteinModelPortali O59618.
    SMRi O59618. Positions 1-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH1956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA31083 ; BAA31083 ; BAA31083 .
    GeneIDi 1442804.
    KEGGi pho:PH1956.

    Phylogenomic databases

    eggNOGi COG2140.
    HOGENOMi HOG000243903.
    KOi K06859.
    OMAi YPADAGH.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci PHOR70601:GJWR-1962-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    HAMAPi MF_01410. G6P_isomerase_arch.
    InterProi IPR010551. G6P_isomerase_prok.
    IPR016758. G6P_isomerase_subgr.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF06560. GPI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiG6PI_PYRHO
    AccessioniPrimary (citable) accession number: O59618
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3