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O59618 (G6PI_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgiA
Ordered Locus Names:PH1956
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_01410

Cofactor

Binds 1 iron ion per subunit By similarity. HAMAP-Rule MF_01410

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_01410

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01410

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01410.

Sequence similarities

Belongs to the archaeal-type GPI family.

Sequence caution

The sequence BAA31083.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Glucose-6-phosphate isomerase HAMAP-Rule MF_01410
PRO_0000185358

Sites

Metal binding881Iron By similarity
Metal binding901Iron By similarity
Metal binding971Iron By similarity
Metal binding1361Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
O59618 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: D7424F200F378C4F

FASTA18921,596
        10         20         30         40         50         60 
MYKEPLGVKV DFESGVIEGA KKLVRRLSDM KGYFLDEETW RELVEREDPV VYEVYAVEQE 

        70         80         90        100        110        120 
EKEGDLNFAT TVLYPGKVGK EFFFTKGHFH AKRDRAEVYI ALKGKGGMLL QTPEGEARWI 

       130        140        150        160        170        180 
PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA IYPADAGHDY GTIAEKGFSK IVIEENGEVK 


VVDNPRWKN 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000001 Genomic DNA. Translation: BAA31083.1. Different initiation.
PIRD71211.
RefSeqNP_143784.1. NC_000961.1.

3D structure databases

ProteinModelPortalO59618.
SMRO59618. Positions 1-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING70601.PH1956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA31083; BAA31083; BAA31083.
GeneID1442804.
KEGGpho:PH1956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2140.
HOGENOMHOG000243903.
KOK06859.
OMAYPADAGH.
ProtClustDBPRK04190.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-1962-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_01410. G6P_isomerase_arch.
InterProIPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF06560. GPI. 1 hit.
[Graphical view]
PIRSFPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG6PI_PYRHO
AccessionPrimary (citable) accession number: O59618
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: February 19, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways