ID   O59504_PYRHO            Unreviewed;       507 AA.
AC   O59504;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=507aa long hypothetical methyl-accepting chemotaxis protein {ECO:0000313|EMBL:BAA30973.1};
GN   OrderedLocusNames=PH1852 {ECO:0000313|EMBL:BAA30973.1};
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA30973.1, ECO:0000313|Proteomes:UP000000752};
RN   [1] {ECO:0000313|EMBL:BAA30973.1, ECO:0000313|Proteomes:UP000000752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
RC   {ECO:0000313|Proteomes:UP000000752};
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y.,
RA   Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; BA000001; BAA30973.1; -; Genomic_DNA.
DR   PIR; F71197; F71197.
DR   AlphaFoldDB; O59504; -.
DR   STRING; 70601.gene:9378856; -.
DR   EnsemblBacteria; BAA30973; BAA30973; BAA30973.
DR   KEGG; pho:PH1852; -.
DR   eggNOG; arCOG02320; Archaea.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF18947; HAMP_2; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..152
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          216..466
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   REGION          453..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          213..244
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        454..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  55973 MW;  385458338C1E6561 CRC64;
     MRGMKFSRKL TLSIFIPLVL VVITAIIIQN IAISDLYDNL EKTMEAVRAG ASIQTVQSTI
     EFAKSQLKKT LWMSIGVMTI VAGVSGVIGF RIMNSVMKPV SEMAKVAEEI ADGKLSHAGE
     LISRIKYREK DEIGKLLEGF RAISTEVLQT LEVITDRMEK ISKGDVTEEL TLHAKGDFES
     ILNSMRKTIV QLRNLMKTVR DLAVTLETRA DDLARISSEI TEAVNQVAEA IQQVSTEAQR
     QQENITQIMD GMNLTADVTQ RTVEAMEEFS SVVNEVISIA REGKEKGEKA ISQVGDIQNA
     MRVISQAVQE VAEMSKNVGE IINAIADIAE QTNLLALNAA IEAARAGELG RGFAVVAQEV
     RNLAEESKEA AERIREILNQ IQDKVEKAVE ETEKGVKIVD NSVDFLRETV GYLMNVGELL
     DDVEDKLQAV KSELANTQEH VENAKKALEN LAASAEETTA SAEEVSASAE EQASSLEEVR
     RNIVELRDIV KKLREAVEFI KVEKEER
//