Reviewed, UniProtKB/Swiss-Prot O59497 (THIL_PYRHO)

Names and origin

Protein names

Recommended name:
    Probable thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	PH1833

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Probable thiamine-monophosphate kinase		PRO_0000096204

Sequences

	Sequence		Length	Mass (Da)
	O59497-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 771B841B267F6511	FASTA	309	34,348
	10 20 30 40 50 60 MTKMRESEII RMFIEEFDNH ALGDDAGFVR FNDSWLLVTS DMLVWRTDVP DFMTPEEAGK 70 80 90 100 110 120 KVVTMNVSDI AAMGGLPLAF FFSLGVPENT DEKTLRGIAK GINKGAKEYG VKIVSGDTNE 130 140 150 160 170 180 AREIIIDGGA IGRGSRLLLR SNAKPGDLVC VTGELGRPLT ALLLWLKGEE IPPKILEKAK 190 200 210 220 230 240 NPKAREREGI ELSNYANSAI DISDGLSKEL WEIARSSNVR IVIDEDKIPV NEEVREIVKD 250 260 270 280 290 300 PIKIALASGE EFELVFTIPK ENLGNISFDF TIIGRVEEGE GVYIKREDKM ERLPILGWEH LKGGDYVNL

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000001 Genomic DNA. Translation: BAA30953.1.
PIR	B71195.
RefSeq	NP_143665.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1442675.
GenomeReviews	Gene locus PH1833 in contig BA000001_GR.
KEGG	pho:PH1833.
NMPDR	fig|70601.1.peg.1789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O59497.
OMA	DEYYFFG.
Enzyme and pathway databases
BRENDA	2.7.4.16. 74679.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_PYRHO

Accession

Primary (citable) accession number: O59497

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)