ID   O59483_PYRHO            Unreviewed;       183 AA.
AC   O59483;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   RecName: Full=CYTH domain-containing protein {ECO:0000259|PROSITE:PS51707};
GN   OrderedLocusNames=PH1819 {ECO:0000313|EMBL:BAA30938.1};
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA30938.1, ECO:0000313|Proteomes:UP000000752};
RN   [1] {ECO:0000313|EMBL:BAA30938.1, ECO:0000313|Proteomes:UP000000752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
RC   {ECO:0000313|Proteomes:UP000000752};
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y.,
RA   Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
RN   [2] {ECO:0007829|PDB:2EEN}
RP   X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS), AND DISULFIDE BONDS.
RA   Bagautdinov B., Kunishima N.;
RT   "Crystal structure of PH1819 protein from Pyrococcus Horikoshii OT3.";
RL   Submitted (FEB-2007) to the PDB data bank.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000001; BAA30938.1; -; Genomic_DNA.
DR   PIR; C71193; C71193.
DR   RefSeq; WP_010885878.1; NC_000961.1.
DR   PDB; 2EEN; X-ray; 1.65 A; A/B=1-183.
DR   PDBsum; 2EEN; -.
DR   AlphaFoldDB; O59483; -.
DR   SMR; O59483; -.
DR   STRING; 70601.gene:9378821; -.
DR   EnsemblBacteria; BAA30938; BAA30938; BAA30938.
DR   GeneID; 1442660; -.
DR   KEGG; pho:PH1819; -.
DR   eggNOG; arCOG01723; Archaea.
DR   OrthoDB; 46040at2157; -.
DR   EvolutionaryTrace; O59483; -.
DR   Proteomes; UP000000752; Chromosome.
DR   CDD; cd07890; CYTH-like_AC_IV-like; 1.
DR   Gene3D; 2.40.320.10; Hypothetical Protein Pfu-838710-001; 1.
DR   InterPro; IPR008173; Adenylyl_cyclase_CyaB.
DR   InterPro; IPR033469; CYTH-like_dom_sf.
DR   InterPro; IPR023577; CYTH_domain.
DR   NCBIfam; TIGR00318; cyaB; 1.
DR   PANTHER; PTHR21028:SF2; CYTH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR21028; SI:CH211-156B7.4; 1.
DR   Pfam; PF01928; CYTH; 1.
DR   SMART; SM01118; CYTH; 1.
DR   SUPFAM; SSF55154; CYTH-like phosphatases; 1.
DR   PROSITE; PS51707; CYTH; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2EEN}.
FT   DOMAIN          1..176
FT                   /note="CYTH"
FT                   /evidence="ECO:0000259|PROSITE:PS51707"
FT   DISULFID        39
FT                   /note="Interchain"
FT                   /evidence="ECO:0007829|PDB:2EEN"
SQ   SEQUENCE   183 AA;  22093 MW;  6DC018F8B7B014DC CRC64;
     MYEVELKGYA NDEIFEKVRE TFEFMRKEIH EDIYYQHPCR DFSKTDEALR IRIKRFNGHN
     EVFLTYKGPK IDEKSKTRLE IEVEIQEDVD KYFELLDRLG FKEVLKVVKT REKYYVEKGV
     TITLDEVEGL GKFIEIETLV KEKDEIPEAV EKLEKILREL GVEKFERRSY LELLLEKRTE
     LNI
//