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Protein

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

hmgA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts HMG-CoA to mevalonate.By similarity

Catalytic activityi

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmgA)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Charge relay systemBy similarity1
Active sitei312Charge relay systemBy similarity1
Active sitei408Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00058; UER00103

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC:1.1.1.34)
Short name:
HMG-CoA reductase
Gene namesi
Name:hmgA
Ordered Locus Names:PH1805
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144641 – 4133-hydroxy-3-methylglutaryl-coenzyme A reductaseAdd BLAST413

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1805

Structurei

3D structure databases

ProteinModelPortaliO59469
SMRiO59469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.Curated

Phylogenomic databases

eggNOGiarCOG04260 Archaea
COG1257 LUCA
HOGENOMiHOG000050844
KOiK00021
OMAiMVTIATE
OrthoDBiPOG093Z03VV

Family and domain databases

CDDicd00643 HMG-CoA_reductase_classI, 1 hit
Gene3Di1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 2 hits
InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR023074 HMG_CoA_Rdtase_cat_sf
IPR023076 HMG_CoA_Rdtase_CS
IPR004554 HMG_CoA_Rdtase_eu_arc
IPR023282 HMG_CoA_Rdtase_N
IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572 PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368 HMG-CoA_red, 1 hit
PRINTSiPR00071 HMGCOARDTASE
SUPFAMiSSF55035 SSF55035, 1 hit
SSF56542 SSF56542, 2 hits
TIGRFAMsiTIGR00533 HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066 HMG_COA_REDUCTASE_1, 1 hit
PS00318 HMG_COA_REDUCTASE_2, 1 hit
PS50065 HMG_COA_REDUCTASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

O59469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGNLNIEE IIEKVANGEI KFYQVEKYVN GDKRLATEIR RKALEKRLGI
60 70 80 90 100
KLHHIGYYSI DPNELIGRNI ENMIGVVQIP MGVAGPLKIN GEYAKGEFYI
110 120 130 140 150
PLATTEGALV ASVNRGCSAL TEAGGVVTTL IDDKMTRAPL IRCPNARRAR
160 170 180 190 200
EVAKWVEENL DYLQEKAVSK VTRHGKLRGV KPFIVGNNLY LRFEFETGDA
210 220 230 240 250
MGMNMVTIAS EEIMKVIEEE FPDVRYLALS GNLCVDKKPN AVNFILGRGK
260 270 280 290 300
TVIAEAVVPR KIVEKKLKTT PELIAEVNYF KNLVGSAQAG SYGFNAHFAN
310 320 330 340 350
IVGAIFLATG QDEAQITEGA HGITIAEVTP DGDLYISITM PSLEIGTVGG
360 370 380 390 400
GTRVPSQREA LEIMGVAGGG DPPGINAKKF AEIVAGAVLA GELSLLAAIA
410
AKHLARAHKM LGR
Length:413
Mass (Da):44,554
Last modified:December 1, 2000 - v2
Checksum:i3FF84B70DA984B84
GO

Sequence cautioni

The sequence BAA30924 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30924.1 Different initiation.
PIRiE71191

Genome annotation databases

EnsemblBacteriaiBAA30924; BAA30924; BAA30924
KEGGipho:PH1805

Similar proteinsi

Entry informationi

Entry nameiHMDH_PYRHO
AccessioniPrimary (citable) accession number: O59469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health