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Protein

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

hmgA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts HMG-CoA to mevalonate.By similarity

Catalytic activityi

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmgA)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Charge relay systemBy similarity
Active sitei312 – 3121Charge relay systemBy similarity
Active sitei408 – 4081Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1802-MONOMER.
UniPathwayiUPA00058; UER00103.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC:1.1.1.34)
Short name:
HMG-CoA reductase
Gene namesi
Name:hmgA
Ordered Locus Names:PH1805
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4134133-hydroxy-3-methylglutaryl-coenzyme A reductasePRO_0000114464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1805.

Structurei

3D structure databases

ProteinModelPortaliO59469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.Curated

Phylogenomic databases

eggNOGiarCOG04260. Archaea.
COG1257. LUCA.
HOGENOMiHOG000050844.
KOiK00021.
OMAiFKTGDAM.

Family and domain databases

CDDicd00643. HMG-CoA_reductase_classI. 1 hit.
Gene3Di1.10.3270.10. 1 hit.
3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEiPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGNLNIEE IIEKVANGEI KFYQVEKYVN GDKRLATEIR RKALEKRLGI
60 70 80 90 100
KLHHIGYYSI DPNELIGRNI ENMIGVVQIP MGVAGPLKIN GEYAKGEFYI
110 120 130 140 150
PLATTEGALV ASVNRGCSAL TEAGGVVTTL IDDKMTRAPL IRCPNARRAR
160 170 180 190 200
EVAKWVEENL DYLQEKAVSK VTRHGKLRGV KPFIVGNNLY LRFEFETGDA
210 220 230 240 250
MGMNMVTIAS EEIMKVIEEE FPDVRYLALS GNLCVDKKPN AVNFILGRGK
260 270 280 290 300
TVIAEAVVPR KIVEKKLKTT PELIAEVNYF KNLVGSAQAG SYGFNAHFAN
310 320 330 340 350
IVGAIFLATG QDEAQITEGA HGITIAEVTP DGDLYISITM PSLEIGTVGG
360 370 380 390 400
GTRVPSQREA LEIMGVAGGG DPPGINAKKF AEIVAGAVLA GELSLLAAIA
410
AKHLARAHKM LGR
Length:413
Mass (Da):44,554
Last modified:December 1, 2000 - v2
Checksum:i3FF84B70DA984B84
GO

Sequence cautioni

The sequence BAA30924 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30924.1. Different initiation.
PIRiE71191.

Genome annotation databases

EnsemblBacteriaiBAA30924; BAA30924; BAA30924.
KEGGipho:PH1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30924.1. Different initiation.
PIRiE71191.

3D structure databases

ProteinModelPortaliO59469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30924; BAA30924; BAA30924.
KEGGipho:PH1805.

Phylogenomic databases

eggNOGiarCOG04260. Archaea.
COG1257. LUCA.
HOGENOMiHOG000050844.
KOiK00021.
OMAiFKTGDAM.

Enzyme and pathway databases

UniPathwayiUPA00058; UER00103.
BioCyciPHOR70601:GJWR-1802-MONOMER.

Family and domain databases

CDDicd00643. HMG-CoA_reductase_classI. 1 hit.
Gene3Di1.10.3270.10. 1 hit.
3.30.70.420. 1 hit.
3.90.770.10. 2 hits.
InterProiIPR002202. HMG_CoA_Rdtase.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR004554. HMG_CoA_Rdtase_eu_arc.
IPR023282. HMG_CoA_Rdtase_N.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd_dom.
IPR009029. HMG_CoA_Rdtase_sub-bd_dom.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PfamiPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSiPR00071. HMGCOARDTASE.
SUPFAMiSSF55035. SSF55035. 1 hit.
SSF56542. SSF56542. 2 hits.
TIGRFAMsiTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEiPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMDH_PYRHO
AccessioniPrimary (citable) accession number: O59469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.