Reviewed, UniProtKB/Swiss-Prot O59443 (KADA_PYRHO)

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adkA
Ordered Locus Names:	PH1753

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00234
Subcellular location	Cytoplasm By similarity HAMAP MF_00234.
Sequence similarities	Belongs to the archaeal adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Adenylate kinase HAMAP MF_00234		PRO_0000131823
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O59443-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 26C834A1BE944D5F	FASTA	196	22,413
	10 20 30 40 50 60 MPFVVIITGI PGVGKSTITK LALQRTRAKF KLINFGDLMF EEALKLKLVK HRDEMRKLPL 70 80 90 100 110 120 EVQRELQMNA AKKIAEMAKN YPILLDTHAT IKTPHGYLLG LPYEVIKILN PNFIVIIEAT 130 140 150 160 170 180 PSEILGRRLR DLKRDRDVET EEQIQRHQDL NRAAAITYAM HSNALIKIIE NHEDKGLEEA 190 VNELVKILDL AVKEYA

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA30867.1.
PIR	D71184.
RefSeq	NP_143591.1.
3D structure databases
SMR	O59443. Positions 4-188.
ModBase	Search...
Genome annotation databases
GeneID	1442598.
GenomeReviews	Gene locus PH1753 in contig BA000001_GR.
KEGG	pho:PH1753.
NMPDR	fig|70601.1.peg.1712.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG402542.
OMA	HRDEMRK.
ProtClustDB	PRK04040.
Enzyme and pathway databases
BioCyc	PHOR70601:PH1753-MONOMER.
BRENDA	2.7.4.3. 74679.
Family and domain databases
HAMAP	MF_00234. Adenylate_kinase_AdkA. [Tree]
ProtoNet	Search...

Entry information

Entry name

KADA_PYRHO

Accession

Primary (citable) accession number: O59443

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	March 2, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)