Reviewed, UniProtKB/Swiss-Prot O59425 (RNP1_PYRHO)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 1
      Short name=RNase P component 1
    EC=3.1.26.5

Gene names

Name:	rnp1
Ordered Locus Names:	PH1771

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00754
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Cellular component	ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro ribonuclease P complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 127

127

Ribonuclease P protein component 1 HAMAP MF_00754

PRO_0000128437

Secondary structure

1

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127

Helix Strand Turn

Details...

Helix

42 – 44

3

Beta strand

52 – 60

9

Helix

61 – 63

3

Beta strand

67 – 73

7

Beta strand

75 – 90

16

Beta strand

93 – 98

6

Beta strand

104 – 108

5

Helix

109 – 112

4

Helix

116 – 119

4

Helix

120 – 123

4

Sequences

	Sequence		Length	Mass (Da)
	O59425-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 840FE2A1234FF0AD	FASTA	127	15,054
	10 20 30 40 50 60 MRRNSKERKN RATRRSQGSY QEIIGRTWIF RGAHRGRVTR RNIIWHELIG LRVRIVGSTH 70 80 90 100 110 120 PAFVGIEGYV IDETRNMLVI AGDRIWKVPK DVCIFEFEAD DGTKIKIPGE RLVGRPEMRL KKRWKKW

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

+

Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

BA000001 Genomic DNA. Translation: BAA30886.1.

PIR

G71186.

RefSeq

NP_143607.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V76	X-ray	2.00	A/B	32-127	[»]
2ZAE	X-ray	2.21	A/C	1-127	[»]

ModBase

Search...

Genome annotation databases

GeneID

1442614.

GenomeReviews

Gene locus PH1771 in contig BA000001_GR.

KEGG

pho:PH1771.

NMPDR

fig|70601.1.peg.1728.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

O59425.

OMA

VINETRN.

Enzyme and pathway databases

BRENDA

3.1.26.5. 74679.

Family and domain databases

HAMAP

MF_00754.
[Tree]

InterPro

IPR002730. RNase_P/MRP_p29-sub_euk/arc.
[Graphical view]

Gene3D

G3DSA:2.30.30.210. RNase_P_Rpp29. 1 hit.

Pfam

PF01868. UPF0086. 1 hit.
[Graphical view]

ProDom

PD009163. UPF0086. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00538. POP4. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RNP1_PYRHO

Accession

Primary (citable) accession number: O59425

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)