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Protein

Intracellular protease 1

Gene

pfpI

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001Nucleophile
Active sitei101 – 1011PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1704-MONOMER.
RETL1328306-WGS:GSTH-3800-MONOMER.
BRENDAi3.4.22.B20. 5244.

Protein family/group databases

MEROPSiC56.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular protease 1 (EC:3.2.-.-)
Alternative name(s):
Intracellular protease I
Gene namesi
Name:pfpI
Ordered Locus Names:PH1704
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Intracellular protease 1PRO_0000157827Add
BLAST

Interactioni

Subunit structurei

Homohexamer formed by a dimer of trimers that assemble into a hollow ring structure.1 Publication

Protein-protein interaction databases

STRINGi70601.PH1704.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi13 – 2513Combined sources
Beta strandi29 – 4113Combined sources
Beta strandi47 – 504Combined sources
Helixi54 – 563Combined sources
Helixi59 – 613Combined sources
Beta strandi63 – 675Combined sources
Helixi72 – 765Combined sources
Helixi80 – 9112Combined sources
Beta strandi96 – 994Combined sources
Turni100 – 1034Combined sources
Helixi104 – 1096Combined sources
Helixi121 – 1233Combined sources
Helixi124 – 1296Combined sources
Beta strandi140 – 1423Combined sources
Beta strandi145 – 1484Combined sources
Helixi151 – 1533Combined sources
Helixi154 – 16512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G2IX-ray2.00A/B/C1-166[»]
ProteinModelPortaliO59413.
SMRiO59413. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59413.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 166166PfpI endopeptidasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C56 family.Curated
Contains 1 PfpI endopeptidase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00769. Archaea.
COG0693. LUCA.
HOGENOMiHOG000063195.
KOiK05520.
OMAiIQGFKHV.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR002818. DJ-1/PfpI.
IPR006286. Peptidase_C56.
[Graphical view]
PfamiPF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01382. PfpI. 1 hit.
PROSITEiPS51276. PEPTIDASE_C56_PFPI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLFLTANE FEDVELIYPY HRLKEEGHEV YIASFERGTI TGKHGYSVKV
60 70 80 90 100
DLTFDKVNPE EFDALVLPGG RAPERVRLNE KAVSIARKMF SEGKPVASIC
110 120 130 140 150
HGPQILISAG VLRGRKGTSY PGIKDDMINA GVEWVDAEVV VDGNWVSSRV
160
PADLYAWMRE FVKLLK
Length:166
Mass (Da):18,624
Last modified:August 1, 1998 - v1
Checksum:iCED046ED1789808C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30818.1.
PIRiC71178.
RefSeqiWP_010885770.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30818; BAA30818; BAA30818.
GeneIDi1442551.
KEGGipho:PH1704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30818.1.
PIRiC71178.
RefSeqiWP_010885770.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G2IX-ray2.00A/B/C1-166[»]
ProteinModelPortaliO59413.
SMRiO59413. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1704.

Protein family/group databases

MEROPSiC56.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30818; BAA30818; BAA30818.
GeneIDi1442551.
KEGGipho:PH1704.

Phylogenomic databases

eggNOGiarCOG00769. Archaea.
COG0693. LUCA.
HOGENOMiHOG000063195.
KOiK05520.
OMAiIQGFKHV.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1704-MONOMER.
RETL1328306-WGS:GSTH-3800-MONOMER.
BRENDAi3.4.22.B20. 5244.

Miscellaneous databases

EvolutionaryTraceiO59413.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR002818. DJ-1/PfpI.
IPR006286. Peptidase_C56.
[Graphical view]
PfamiPF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01382. PfpI. 1 hit.
PROSITEiPS51276. PEPTIDASE_C56_PFPI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.
  2. "Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution."
    Du X., Choi I.-G., Kim R., Wang W., Jancarik J., Yokota H., Kim S.-H.
    Proc. Natl. Acad. Sci. U.S.A. 97:14079-14084(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiPFPI_PYRHO
AccessioniPrimary (citable) accession number: O59413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.