Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Intracellular protease 1

Gene

pfpI

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100Nucleophile1
Active sitei101PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.22.B20. 5244.

Protein family/group databases

MEROPSiC56.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular protease 1 (EC:3.2.-.-)
Alternative name(s):
Intracellular protease I
Gene namesi
Name:pfpI
Ordered Locus Names:PH1704
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001578271 – 166Intracellular protease 1Add BLAST166

Interactioni

Subunit structurei

Homohexamer formed by a dimer of trimers that assemble into a hollow ring structure.1 Publication

Protein-protein interaction databases

STRINGi70601.PH1704.

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi13 – 25Combined sources13
Beta strandi29 – 41Combined sources13
Beta strandi47 – 50Combined sources4
Helixi54 – 56Combined sources3
Helixi59 – 61Combined sources3
Beta strandi63 – 67Combined sources5
Helixi72 – 76Combined sources5
Helixi80 – 91Combined sources12
Beta strandi96 – 99Combined sources4
Turni100 – 103Combined sources4
Helixi104 – 109Combined sources6
Helixi121 – 123Combined sources3
Helixi124 – 129Combined sources6
Beta strandi140 – 142Combined sources3
Beta strandi145 – 148Combined sources4
Helixi151 – 153Combined sources3
Helixi154 – 165Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G2IX-ray2.00A/B/C1-166[»]
ProteinModelPortaliO59413.
SMRiO59413.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59413.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 166PfpI endopeptidasePROSITE-ProRule annotationAdd BLAST166

Sequence similaritiesi

Belongs to the peptidase C56 family.Curated
Contains 1 PfpI endopeptidase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00769. Archaea.
COG0693. LUCA.
HOGENOMiHOG000063195.
KOiK05520.
OMAiVATICHG.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR002818. DJ-1/PfpI.
IPR006286. Peptidase_C56.
[Graphical view]
PfamiPF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01382. PfpI. 1 hit.
PROSITEiPS51276. PEPTIDASE_C56_PFPI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLFLTANE FEDVELIYPY HRLKEEGHEV YIASFERGTI TGKHGYSVKV
60 70 80 90 100
DLTFDKVNPE EFDALVLPGG RAPERVRLNE KAVSIARKMF SEGKPVASIC
110 120 130 140 150
HGPQILISAG VLRGRKGTSY PGIKDDMINA GVEWVDAEVV VDGNWVSSRV
160
PADLYAWMRE FVKLLK
Length:166
Mass (Da):18,624
Last modified:August 1, 1998 - v1
Checksum:iCED046ED1789808C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30818.1.
PIRiC71178.
RefSeqiWP_010885770.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30818; BAA30818; BAA30818.
GeneIDi1442551.
KEGGipho:PH1704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30818.1.
PIRiC71178.
RefSeqiWP_010885770.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G2IX-ray2.00A/B/C1-166[»]
ProteinModelPortaliO59413.
SMRiO59413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1704.

Protein family/group databases

MEROPSiC56.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30818; BAA30818; BAA30818.
GeneIDi1442551.
KEGGipho:PH1704.

Phylogenomic databases

eggNOGiarCOG00769. Archaea.
COG0693. LUCA.
HOGENOMiHOG000063195.
KOiK05520.
OMAiVATICHG.

Enzyme and pathway databases

BRENDAi3.4.22.B20. 5244.

Miscellaneous databases

EvolutionaryTraceiO59413.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR002818. DJ-1/PfpI.
IPR006286. Peptidase_C56.
[Graphical view]
PfamiPF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01382. PfpI. 1 hit.
PROSITEiPS51276. PEPTIDASE_C56_PFPI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPFPI_PYRHO
AccessioniPrimary (citable) accession number: O59413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.