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O59390 (HOSA_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative homocitrate synthase
EC=2.3.3.14
Gene names
Ordered Locus Names:PH1727
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA.

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarboxylic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionhomocitrate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Putative homocitrate synthase
PRO_0000140422

Sequences

Sequence LengthMass (Da)Tools
O59390 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 3DCADFE85AF95794

FASTA36140,858
        10         20         30         40         50         60 
MILDSTLREG EQTPGVNYSP EQRLRIALAL DEIGVDFIEV GHPAVSKDVF IGIKLIASQD 

        70         80         90        100        110        120 
LNANLLAHSR ALLEDIDYVI QADVEWVGIF FCLSNACLRK RFRMSLSQAL ERISKAIEYA 

       130        140        150        160        170        180 
KDHGLKVRFT PEDTTRTEWE NLRRAIELAK ELKVDRISVA DTTGGTHPLR FYTLVKKVVN 

       190        200        210        220        230        240 
FGIPVNVHCH NDLGLALANA IMGIEGGATV VDATVNGLGE RAGIVDLAQI VTVLYYHYGV 

       250        260        270        280        290        300 
KKYRLDKLYE ISRMVSEITG IALQPNYPIV GENAFTHKAG LHVSAVLKDP RFYEFLPAEV 

       310        320        330        340        350        360 
FGRERTIYVD RFAGKDTIRY YLQKLGINDE EFVKVLLKRV KSSREPFTWD KFIEEVRRLK 


T

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References

[1]"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3."
Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. expand/collapse author list , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.
DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000001 Genomic DNA. Translation: BAA30841.1.
PIRB71181.
RefSeqNP_143566.1. NC_000961.1.

3D structure databases

ProteinModelPortalO59390.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000000775; EBPYRP00000000775; EBPYRG00000000775.
GeneID1442571.
GenomeReviewsGene locus PH1727 in contig BA000001_GR.
KEGGpho:PH1727.
NMPDRfig|70601.1.peg.1685.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022307.
HOGENOMHBG701974.
OMACLLAREI.
PhylomeDBO59390.
ProtClustDBPRK11858.

Enzyme and pathway databases

BioCycPHOR70601:PH1727-MONOMER.

Family and domain databases

InterProIPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR011872. Homocitrate_synth_fun/arc.
IPR000891. PYR_CT.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01649.
PfamPF00682. HMGL-like. 1 hit.
[Graphical view]
TIGRFAMsTIGR02146. LysS_fung_arch. 1 hit.
PROSITEPS00815. AIPM_HOMOCIT_SYNTH_1. False negative.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOSA_PYRHO
AccessionPrimary (citable) accession number: O59390
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: August 1, 1998
Last modified: December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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