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Protein

Probable thymidylate kinase

Gene

tmk

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:PH1695
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553951 – 205Probable thymidylate kinaseAdd BLAST205

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1695.

Structurei

3D structure databases

ProteinModelPortaliO59366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiSSLAYQW.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGYFIVLEG IDGSGKTTQA KLLAEWFEDK GYEVLLTKEP TDSELGKLIR
60 70 80 90 100
RIILEESVID GSKISYEAEA LLFAADRAEH VKKIILPALS EGKVVICDRY
110 120 130 140 150
FYSSLAYQWA RGLDLNWLIQ VNSFAPRPDL AILLDLPVKE SLRRIKLRGT
160 170 180 190 200
LTEFDKIVEL QRKVRHNYLK LAEMFPEMRI VNALSSIEDI HSDIVALVKH

ELLGL
Length:205
Mass (Da):23,399
Last modified:August 1, 1998 - v1
Checksum:iE7F623520E97C11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30808.1.
PIRiA71177.
RefSeqiWP_010885760.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30808; BAA30808; BAA30808.
GeneIDi1442541.
KEGGipho:PH1695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30808.1.
PIRiA71177.
RefSeqiWP_010885760.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO59366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30808; BAA30808; BAA30808.
GeneIDi1442541.
KEGGipho:PH1695.

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiSSLAYQW.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_PYRHO
AccessioniPrimary (citable) accession number: O59366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.