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Protein

Probable thymidylate kinase

Gene

tmk

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1641-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:PH1695
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553951 – 205Probable thymidylate kinaseAdd BLAST205

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1695

Structurei

3D structure databases

ProteinModelPortaliO59366
SMRiO59366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01891 Archaea
COG0125 LUCA
HOGENOMiHOG000229077
KOiK00943
OMAiFLYTADH
OrthoDBiPOG093Z0A1C

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

O59366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGYFIVLEG IDGSGKTTQA KLLAEWFEDK GYEVLLTKEP TDSELGKLIR
60 70 80 90 100
RIILEESVID GSKISYEAEA LLFAADRAEH VKKIILPALS EGKVVICDRY
110 120 130 140 150
FYSSLAYQWA RGLDLNWLIQ VNSFAPRPDL AILLDLPVKE SLRRIKLRGT
160 170 180 190 200
LTEFDKIVEL QRKVRHNYLK LAEMFPEMRI VNALSSIEDI HSDIVALVKH

ELLGL
Length:205
Mass (Da):23,399
Last modified:August 1, 1998 - v1
Checksum:iE7F623520E97C11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30808.1
PIRiA71177
RefSeqiWP_010885760.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30808; BAA30808; BAA30808
GeneIDi1442541
KEGGipho:PH1695

Similar proteinsi

Entry informationi

Entry nameiKTHY_PYRHO
AccessioniPrimary (citable) accession number: O59366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health