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O59291 (MVK_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mevalonate kinase

Short name=MK
Short name=MVK
EC=2.7.1.36
Gene names
Name:mvk
Ordered Locus Names:PH1625
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids By similarity. HAMAP-Rule MF_00217

Catalytic activity

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. HAMAP-Rule MF_00217

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00217

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. HAMAP-Rule MF_00217

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00217

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00217.

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processisopentenyl diphosphate biosynthetic process, mevalonate pathway

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mevalonate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Mevalonate kinase HAMAP-Rule MF_00217
PRO_0000156669

Regions

Nucleotide binding111 – 12111ATP Potential

Sites

Active site1621Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
O59291 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 17D0A9E1D22A1EB1

FASTA33535,686
        10         20         30         40         50         60 
MVKYVLASAP AKVILFGEHS VVYGKPAIAS AIELRTYVRA QFNDSGNIKI EAHDIKTPGL 

        70         80         90        100        110        120 
IVSFSEDKIY FETDYGKAAE VLSYVRYAIE LALEESDKRV GIDVSITSQI PVGAGLGSSA 

       130        140        150        160        170        180 
AVAVATIGAV SRLLGLELSK EEIAKLGHKV ELLVQGASSG IDPTVSAVGG FLYYKQGKFE 

       190        200        210        220        230        240 
PLPFMELPIV VGYTGSTGST KELVAMVRKR YEEMPELVEP ILEAMGKLVD KAKEIILSKL 

       250        260        270        280        290        300 
DEEEKLTKLG ELMNINHGLL DALGVSTKKL GELVYAARTA GAIGAKLTGA GGGGCMYALA 

       310        320        330 
PGRQREVATA IKIAGGIPMI TRVSREGLRI EEVSR 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000001 Genomic DNA. Translation: BAA30737.1.
PIRA71042.
RefSeqNP_143478.1. NC_000961.1.

3D structure databases

ProteinModelPortalO59291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING70601.PH1625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA30737; BAA30737; BAA30737.
GeneID1442477.
KEGGpho:PH1625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1577.
HOGENOMHOG000080810.
KOK00869.
OMAGCMIALP.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-1626-MONOMER.
UniPathwayUPA00057; UER00098.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00217. Mevalonate_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR022937. Mevalonate_kinase_arc.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10457:SF10. PTHR10457:SF10. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSPR00959. MEVGALKINASE.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00549. mevalon_kin. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMVK_PYRHO
AccessionPrimary (citable) accession number: O59291
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways