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O59291

- MVK_PYRHO

UniProt

O59291 - MVK_PYRHO

Protein

Mevalonate kinase

Gene

mvk

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.UniRule annotation

    Catalytic activityi

    ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei162 – 1621Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi111 – 12111ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. mevalonate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-1626-MONOMER.
    UniPathwayiUPA00057; UER00098.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mevalonate kinaseUniRule annotation (EC:2.7.1.36UniRule annotation)
    Short name:
    MKUniRule annotation
    Short name:
    MVKUniRule annotation
    Gene namesi
    Name:mvkUniRule annotation
    Ordered Locus Names:PH1625
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Mevalonate kinasePRO_0000156669Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi70601.PH1625.

    Structurei

    3D structure databases

    ProteinModelPortaliO59291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. Mevalonate kinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1577.
    HOGENOMiHOG000080810.
    KOiK00869.
    OMAiGCMIALP.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00217. Mevalonate_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006205. Mev_gal_kin.
    IPR006206. Mevalonate/galactokinase.
    IPR022937. Mevalonate_kinase_arc.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10457:SF10. PTHR10457:SF10. 1 hit.
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PRINTSiPR00959. MEVGALKINASE.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59291-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKYVLASAP AKVILFGEHS VVYGKPAIAS AIELRTYVRA QFNDSGNIKI    50
    EAHDIKTPGL IVSFSEDKIY FETDYGKAAE VLSYVRYAIE LALEESDKRV 100
    GIDVSITSQI PVGAGLGSSA AVAVATIGAV SRLLGLELSK EEIAKLGHKV 150
    ELLVQGASSG IDPTVSAVGG FLYYKQGKFE PLPFMELPIV VGYTGSTGST 200
    KELVAMVRKR YEEMPELVEP ILEAMGKLVD KAKEIILSKL DEEEKLTKLG 250
    ELMNINHGLL DALGVSTKKL GELVYAARTA GAIGAKLTGA GGGGCMYALA 300
    PGRQREVATA IKIAGGIPMI TRVSREGLRI EEVSR 335
    Length:335
    Mass (Da):35,686
    Last modified:August 1, 1998 - v1
    Checksum:i17D0A9E1D22A1EB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30737.1.
    PIRiA71042.
    RefSeqiNP_143478.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA30737; BAA30737; BAA30737.
    GeneIDi1442477.
    KEGGipho:PH1625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30737.1 .
    PIRi A71042.
    RefSeqi NP_143478.1. NC_000961.1.

    3D structure databases

    ProteinModelPortali O59291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH1625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA30737 ; BAA30737 ; BAA30737 .
    GeneIDi 1442477.
    KEGGi pho:PH1625.

    Phylogenomic databases

    eggNOGi COG1577.
    HOGENOMi HOG000080810.
    KOi K00869.
    OMAi GCMIALP.

    Enzyme and pathway databases

    UniPathwayi UPA00057 ; UER00098 .
    BioCyci PHOR70601:GJWR-1626-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00217. Mevalonate_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006205. Mev_gal_kin.
    IPR006206. Mevalonate/galactokinase.
    IPR022937. Mevalonate_kinase_arc.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10457:SF10. PTHR10457:SF10. 1 hit.
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00959. MEVGALKINASE.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00549. mevalon_kin. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiMVK_PYRHO
    AccessioniPrimary (citable) accession number: O59291
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3