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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431UniRule annotation
Metal bindingi43 – 431MagnesiumUniRule annotation
Binding sitei48 – 481SubstrateUniRule annotation
Binding sitei60 – 601SubstrateUniRule annotation
Active sitei91 – 911Proton acceptorUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei213 – 2131SubstrateUniRule annotation
Metal bindingi232 – 2321MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1592-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:PH1590
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)PRO_0000123739Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH1590.

Structurei

3D structure databases

ProteinModelPortaliO59258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 474Substrate bindingUniRule annotation
Regioni88 – 903Substrate bindingUniRule annotation
Regioni219 – 2213Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK15888.
OMAiWNRPKLE.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYRIISHIP KIFFKPAYDL YERYLIEKVK SGVLPKHVAI IMDGNRRWAR
60 70 80 90 100
KHEKPPWYGH LFGSKKLEEI LEWCHELGIR ILTVYAFSTE NFKRSKEEVD
110 120 130 140 150
RLMKLFEEKF RELVTDKRVH EYGVRVNVIG RKELLPKSVR DAVEEAERAT
160 170 180 190 200
RKYNNYILNV ALAYGGRSEI VDAVKDIARD VISGKLRIEE IDEELLRRYL
210 220 230 240 250
YVPNMPDPDI VIRTGGEVRI SNFLLYQIAY SELFFVDVYF PEFRKIDFLR
260
IIREFQKRER RFGR
Length:264
Mass (Da):31,640
Last modified:August 1, 1998 - v1
Checksum:i974DC34BECF7B686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30702.1.
PIRiF71037.
RefSeqiWP_010885664.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30702; BAA30702; BAA30702.
GeneIDi1442443.
KEGGipho:PH1590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30702.1.
PIRiF71037.
RefSeqiWP_010885664.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO59258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30702; BAA30702; BAA30702.
GeneIDi1442443.
KEGGipho:PH1590.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK15888.
OMAiWNRPKLE.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1592-MONOMER.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPS_PYRHO
AccessioniPrimary (citable) accession number: O59258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.