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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43UniRule annotation1
Metal bindingi43MagnesiumUniRule annotation1
Binding sitei48SubstrateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei91Proton acceptorUniRule annotation1
Binding sitei92SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei213SubstrateUniRule annotation1
Metal bindingi232MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1543-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:PH1590
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237391 – 264Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)Add BLAST264

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH1590

Structurei

3D structure databases

ProteinModelPortaliO59258
SMRiO59258
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 47Substrate bindingUniRule annotation4
Regioni88 – 90Substrate bindingUniRule annotation3
Regioni219 – 221Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532 Archaea
COG0020 LUCA
HOGENOMiHOG000006056
KOiK15888
OMAiFDRRDLW
OrthoDBiPOG093Z09YM

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

O59258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYRIISHIP KIFFKPAYDL YERYLIEKVK SGVLPKHVAI IMDGNRRWAR
60 70 80 90 100
KHEKPPWYGH LFGSKKLEEI LEWCHELGIR ILTVYAFSTE NFKRSKEEVD
110 120 130 140 150
RLMKLFEEKF RELVTDKRVH EYGVRVNVIG RKELLPKSVR DAVEEAERAT
160 170 180 190 200
RKYNNYILNV ALAYGGRSEI VDAVKDIARD VISGKLRIEE IDEELLRRYL
210 220 230 240 250
YVPNMPDPDI VIRTGGEVRI SNFLLYQIAY SELFFVDVYF PEFRKIDFLR
260
IIREFQKRER RFGR
Length:264
Mass (Da):31,640
Last modified:August 1, 1998 - v1
Checksum:i974DC34BECF7B686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30702.1
PIRiF71037
RefSeqiWP_010885664.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30702; BAA30702; BAA30702
GeneIDi1442443
KEGGipho:PH1590

Similar proteinsi

Entry informationi

Entry nameiUPPS_PYRHO
AccessioniPrimary (citable) accession number: O59258
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health