Reviewed, UniProtKB/Swiss-Prot O59240 (PDAD_PYRHO)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase
      Short name=PvlArgDC
    EC=4.1.1.19
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	PH1609

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity.
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 43	43	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_0000023332
	Chain	44 – 158	115	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_0000023333
Sites
	Site	43 – 44	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	44	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O59240-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 7D9CE49C99E8D7FB	FASTA	158	17,124
	10 20 30 40 50 60 MTWITPKKAI MLAAAAEGGT KLNAFDNALL KMGIGNVNLV KLSSVIPAHI EWLDELPKNI 70 80 90 100 110 120 PIGMLLPTVY AHIESDEPGS TISAALGVGI SEGNEGGLIY EYAGYCKREE AEDMVRKMVE 130 140 150 EGFKVRGWKL KEFKVVSAEI TVKEKPAAAV AAVIMFPY

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000001 Genomic DNA. Translation: BAA30721.1.
PIR	A71040.
RefSeq	NP_143462.1.
3D structure databases
HSSP	HSSP built from PDB template 1N2M based on UniProtKB Q57764.
ModBase	Search...
Genome annotation databases
GeneID	1442461.
GenomeReviews	Gene locus PH1609 in contig BA000001_GR.
KEGG	pho:PH1609.
NMPDR	fig|70601.1.peg.1575.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O59240.
OMA	LVPTAYG.
Enzyme and pathway databases
BRENDA	4.1.1.19. 74679.
Family and domain databases
HAMAP	MF_01404. [Tree]
InterPro	IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. DUF44. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00286. PvlArgDC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_PYRHO

Accession

Primary (citable) accession number: O59240

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)