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Protein

Pyruvoyl-dependent arginine decarboxylase

Gene

pdaD

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

pyruvateUniRule annotationNote: Binds 1 pyruvoyl group covalently per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyruvate

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1561-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvoyl-dependent arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
PvlArgDCUniRule annotation
Cleaved into the following 2 chains:
Pyruvoyl-dependent arginine decarboxylase subunit betaUniRule annotation
Pyruvoyl-dependent arginine decarboxylase subunit alphaUniRule annotation
Gene namesi
Name:pdaDUniRule annotation
Ordered Locus Names:PH1609
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000233321 – 43Pyruvoyl-dependent arginine decarboxylase subunit betaUniRule annotationAdd BLAST43
ChainiPRO_000002333344 – 158Pyruvoyl-dependent arginine decarboxylase subunit alphaUniRule annotationAdd BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44Pyruvic acid (Ser)UniRule annotation1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43 – 44Cleavage (non-hydrolytic)UniRule annotation2

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1609

Structurei

3D structure databases

ProteinModelPortaliO59240
SMRiO59240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdaD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04490 Archaea
COG1945 LUCA
HOGENOMiHOG000012204
KOiK02626
OMAiAAALWYK
OrthoDBiPOG093Z0D0B

Family and domain databases

Gene3Di3.50.20.10, 1 hit
HAMAPiMF_01404 PvlArgDC, 1 hit
InterProiView protein in InterPro
IPR016104 Pyr-dep_his/arg-deCO2ase
IPR016105 Pyr-dep_his/arg-deCO2ase_sand
IPR002724 Pyruvoyl-dep_arg_deCO2ase
PANTHERiPTHR40438 PTHR40438, 1 hit
PfamiView protein in Pfam
PF01862 PvlArgDC, 1 hit
PIRSFiPIRSF005216 Pyruvoyl-dep_arg_deCO2ase, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010449 Pyruvoyl-dep_arg_deCO2ase, 1 hit
SFLDiSFLDG01170 Pyruvoyl-dependent_arginine_de, 1 hit
SUPFAMiSSF56271 SSF56271, 1 hit
TIGRFAMsiTIGR00286 TIGR00286, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O59240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWITPKKAI MLAAAAEGGT KLNAFDNALL KMGIGNVNLV KLSSVIPAHI
60 70 80 90 100
EWLDELPKNI PIGMLLPTVY AHIESDEPGS TISAALGVGI SEGNEGGLIY
110 120 130 140 150
EYAGYCKREE AEDMVRKMVE EGFKVRGWKL KEFKVVSAEI TVKEKPAAAV

AAVIMFPY
Length:158
Mass (Da):17,124
Last modified:August 1, 1998 - v1
Checksum:i7D9CE49C99E8D7FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30721.1
PIRiA71040
RefSeqiWP_010885682.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30721; BAA30721; BAA30721
GeneIDi1442461
KEGGipho:PH1609

Similar proteinsi

Entry informationi

Entry nameiPDAD_PYRHO
AccessioniPrimary (citable) accession number: O59240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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