O59181 (O59181_PYRHO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphorylase RuleBase RU000587
EC=2.4.1.1 RuleBase RU000587

Gene names

Ordered Locus Names:

PH1512

Organism

Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]

Taxonomic identifier

70601 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	837 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties By similarity. RuleBase RU000587
Catalytic activity	(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate. RuleBase RU000587
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000587
Sequence similarities	Belongs to the glycogen phosphorylase family. RuleBase RU004179

Ontologies

Keywords
Biological process	Carbohydrate metabolism RuleBase RU000587
Molecular function	Glycosyltransferase RuleBase RU000587 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphorylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O59181 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 0014DEDA5D26F832	FASTA	837	97,672
	10 20 30 40 50 60 MIMMKVDNST KERILEKLPE NLSRLADLAY NYWWSWDHKA MKLWQKIDEE HWREYKNPVK 70 80 90 100 110 120 LLLEAPESRL RELSRDDNFL DLYELVIERF DDYMKETATW FSTNYPRWDK PIIYLCMEYG 130 140 150 160 170 180 IGKSLPIYSG GLGILAGDHL KTASDLGLPM VAIGLLYKHG YFKQEIDING RQIERFPEYN 190 200 210 220 230 240 VKEMPIRQVL DNDGSPLLID VPIEDRMIKA RVFLVEVGRV KLYLLDTDVP ENSEADRKIC 250 260 270 280 290 300 DYLYNAEPDK RIKQEILIGI GGMRLLKALE IDPGVVHLNE GHAAFANFER IRWFIEKGLS 310 320 330 340 350 360 FEEALEIVRG TSVFTTHTPV PAGHDVFPVE FVREKLRAFF DGLPEDKLLG LGKVNDSDPN 370 380 390 400 410 420 FNMTVLAIRT SEFVNAVSKL HAKVTREMWA NLWPGVPPDE IPIEPITNGI HTPTWVNENL 430 440 450 460 470 480 AKLYEIYIGK IWREHVNLEG IWYAIERIPD HELWEAHLKA KRELIELIRR KIMKRNERLG 490 500 510 520 530 540 IDEPIPDVDE NALIIGFARR FATYKRAILL FTDLERLKRI VNNRDRPVYI IFGGKAHPMD 550 560 570 580 590 600 EAGKEYLRRV YEVSQMPEFK GKIILIENYD LGSARILISG VDVWLNTPKR PLEASGTSGM 610 620 630 640 650 660 KAGLNGVLNL STFDGWWVEG YNGRNGWVIG DATLEPETEE DDYLDAMSLY DLLENVVIPM 670 680 690 700 710 720 YYENREGWIR IMKESIKSIA PRFSTYRMLK EYMTKFYSRA METGIYLSRD NFRWAKELAS 730 740 750 760 770 780 WKEKIMLGWN DVEIEDVKVN ENRIEAIIRL GTIRPEDVRV ELYYGVRGDG KIMEPYTVEL 790 800 810 820 830 RKTKELGTGK YLYTYSGKAL KNFNHECWHY SIRVYAYHPM IPGKFLLGGY IKWRDLK

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 and OT3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA30620.1.
PIR	D71027.
RefSeq	NP_143372.1. NC_000961.1.
3D structure databases
ProteinModelPortal	O59181.
ModBase	Search...
Protein family/group databases
CAZy	GT35. Glycosyltransferase Family 35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000001785; EBPYRP00000001785; EBPYRG00000001785.
GeneID	1443828.
GenomeReviews	Gene locus PH1512 in contig BA000001_GR.
KEGG	pho:PH1512.
NMPDR	fig|70601.1.peg.1481.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023360.
HOGENOM	HBG302557.
OMA	GWWPEAC.
PhylomeDB	O59181.
ProtClustDB	CLSK785506.
Enzyme and pathway databases
BioCyc	PHOR70601:PH1512-MONOMER.
Family and domain databases
InterPro	IPR011834. Agluc_phsphrylas. IPR000811. Glyco_trans_35. IPR024517. Glycogen_phosphorylase_DUF3417. [Graphical view]
KO	K00688.
PANTHER	PTHR11468. Glyco_trans_35. 1 hit.
Pfam	PF11897. DUF3417. 1 hit. PF00343. Phosphorylase. 1 hit. [Graphical view]
PIRSF	PIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMs	TIGR02094. More_P_ylases. 1 hit.
PROSITE	PS00102. PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O59181_PYRHO

Accession

Primary (citable) accession number: O59181

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)