Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O59147 (SYR_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:PH1478
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 629629Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151653

Regions

Motif128 – 13811"HIGH" region HAMAP-Rule MF_00123

Secondary structure

........................................................................................... 629
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O59147 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 34CE2D841DBAD48A

FASTA62972,340
        10         20         30         40         50         60 
MLMEIRESVK ERIEEIIKEI APQWEGEIEL KETPDPKLGD FGTPIAFKLA KLLKRPPIEI 

        70         80         90        100        110        120 
AEKIVEKLKL NLPEGIKDVK AVNGYINVFI DYPHFARILI NDILAKGDRF GSSEIGKGKK 

       130        140        150        160        170        180 
VIVEHTSVNP TKPLHMGHAR NAILGDVMAR ILRFLGYEVE VQNYIDDLGI QFAQVYWGYL 

       190        200        210        220        230        240 
RLKEEFERIM NELRERGLKD NPIDHALGLL YVEVNRRLED NPELENEIRD IMKKLESGEL 

       250        260        270        280        290        300 
YGRKLAEEVV RAQMVTTYKL GVKYDLLVWE SDIVRRKLFE IALELLSKNE NFYIPSDGKY 

       310        320        330        340        350        360 
RGAFVMDLRK LFPDMKNPIL VLRRSDGTAT YTGKDIAYHL WKFGKIDVDL LYKEWDSTTW 

       370        380        390        400        410        420 
TTAPDGKSMP NKFGNANIVI NVIGAEQKHP QLAIKYALQL LGFEDAAANL YHLAYEHVER 

       430        440        450        460        470        480 
PEGKFSGRKG TWVGFTVDEV IQEAVKRARE LIEEKNPALS DEEKAEVAEK VGIGAIRYNL 

       490        500        510        520        530        540 
IKYSPDKKII FRWEDVLNFE GESAPYIQYA HARCSSILRK AEEEGIKVDP ETLFKNADFT 

       550        560        570        580        590        600 
KLSERERELV IMLSKFPRIV EQAGKDVKPH LIAWFANELA SLFNKFYMDH PVLKAEEGVR 

       610        620 
EARLLLVMAV EQVLKNALYL MGIEAPERM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000001 Genomic DNA. Translation: BAA30585.1.
PIRA71023.
RefSeqNP_143342.1. NC_000961.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZUEX-ray2.00A1-629[»]
2ZUFX-ray2.30A1-629[»]
ProteinModelPortalO59147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING70601.PH1478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA30585; BAA30585; BAA30585.
GeneID1443796.
KEGGpho:PH1478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMANFERNSA.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-1477-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO59147.

Entry information

Entry nameSYR_PYRHO
AccessionPrimary (citable) accession number: O59147
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries