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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.19. 5244.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:PH1478
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516531 – 629Arginine--tRNA ligaseAdd BLAST629

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1478.

Structurei

Secondary structure

1629
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 20Combined sources15
Helixi36 – 38Combined sources3
Beta strandi40 – 43Combined sources4
Helixi45 – 53Combined sources9
Helixi57 – 68Combined sources12
Beta strandi76 – 82Combined sources7
Beta strandi85 – 90Combined sources6
Helixi92 – 106Combined sources15
Helixi107 – 109Combined sources3
Turni115 – 118Combined sources4
Beta strandi120 – 124Combined sources5
Helixi136 – 154Combined sources19
Beta strandi158 – 165Combined sources8
Helixi170 – 181Combined sources12
Helixi183 – 196Combined sources14
Helixi203 – 220Combined sources18
Helixi222 – 224Combined sources3
Helixi225 – 237Combined sources13
Beta strandi238 – 240Combined sources3
Helixi243 – 260Combined sources18
Beta strandi265 – 269Combined sources5
Helixi270 – 275Combined sources6
Helixi278 – 287Combined sources10
Beta strandi296 – 298Combined sources3
Turni299 – 302Combined sources4
Beta strandi304 – 307Combined sources4
Turni309 – 311Combined sources3
Beta strandi313 – 316Combined sources4
Beta strandi319 – 323Combined sources5
Helixi331 – 342Combined sources12
Beta strandi351 – 354Combined sources4
Beta strandi356 – 358Combined sources3
Beta strandi360 – 362Combined sources3
Beta strandi377 – 384Combined sources8
Helixi385 – 387Combined sources3
Helixi388 – 400Combined sources13
Helixi404 – 408Combined sources5
Beta strandi410 – 415Combined sources6
Beta strandi418 – 420Combined sources3
Turni427 – 434Combined sources8
Helixi437 – 455Combined sources19
Helixi461 – 481Combined sources21
Helixi493 – 496Combined sources4
Beta strandi500 – 503Combined sources4
Helixi504 – 523Combined sources20
Helixi530 – 536Combined sources7
Helixi544 – 565Combined sources22
Helixi570 – 589Combined sources20
Helixi599 – 620Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZUEX-ray2.00A1-629[»]
2ZUFX-ray2.30A1-629[»]
ProteinModelPortaliO59147.
SMRiO59147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59147.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi128 – 138"HIGH" regionAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
HOGENOMiHOG000247213.
KOiK01887.
OMAiKLVGNYY.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 2 hits.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMEIRESVK ERIEEIIKEI APQWEGEIEL KETPDPKLGD FGTPIAFKLA
60 70 80 90 100
KLLKRPPIEI AEKIVEKLKL NLPEGIKDVK AVNGYINVFI DYPHFARILI
110 120 130 140 150
NDILAKGDRF GSSEIGKGKK VIVEHTSVNP TKPLHMGHAR NAILGDVMAR
160 170 180 190 200
ILRFLGYEVE VQNYIDDLGI QFAQVYWGYL RLKEEFERIM NELRERGLKD
210 220 230 240 250
NPIDHALGLL YVEVNRRLED NPELENEIRD IMKKLESGEL YGRKLAEEVV
260 270 280 290 300
RAQMVTTYKL GVKYDLLVWE SDIVRRKLFE IALELLSKNE NFYIPSDGKY
310 320 330 340 350
RGAFVMDLRK LFPDMKNPIL VLRRSDGTAT YTGKDIAYHL WKFGKIDVDL
360 370 380 390 400
LYKEWDSTTW TTAPDGKSMP NKFGNANIVI NVIGAEQKHP QLAIKYALQL
410 420 430 440 450
LGFEDAAANL YHLAYEHVER PEGKFSGRKG TWVGFTVDEV IQEAVKRARE
460 470 480 490 500
LIEEKNPALS DEEKAEVAEK VGIGAIRYNL IKYSPDKKII FRWEDVLNFE
510 520 530 540 550
GESAPYIQYA HARCSSILRK AEEEGIKVDP ETLFKNADFT KLSERERELV
560 570 580 590 600
IMLSKFPRIV EQAGKDVKPH LIAWFANELA SLFNKFYMDH PVLKAEEGVR
610 620
EARLLLVMAV EQVLKNALYL MGIEAPERM
Length:629
Mass (Da):72,340
Last modified:August 1, 1998 - v1
Checksum:i34CE2D841DBAD48A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30585.1.
PIRiA71023.
RefSeqiWP_010885558.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30585; BAA30585; BAA30585.
GeneIDi1443796.
KEGGipho:PH1478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30585.1.
PIRiA71023.
RefSeqiWP_010885558.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZUEX-ray2.00A1-629[»]
2ZUFX-ray2.30A1-629[»]
ProteinModelPortaliO59147.
SMRiO59147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30585; BAA30585; BAA30585.
GeneIDi1443796.
KEGGipho:PH1478.

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
HOGENOMiHOG000247213.
KOiK01887.
OMAiKLVGNYY.

Enzyme and pathway databases

BRENDAi6.1.1.19. 5244.

Miscellaneous databases

EvolutionaryTraceiO59147.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 2 hits.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYR_PYRHO
AccessioniPrimary (citable) accession number: O59147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.