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O59147

- SYR_PYRHO

UniProt

O59147 - SYR_PYRHO

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-1477-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:argS
    Ordered Locus Names:PH1478
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 629629Arginine--tRNA ligasePRO_0000151653Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi70601.PH1478.

    Structurei

    Secondary structure

    1
    629
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 2015
    Helixi36 – 383
    Beta strandi40 – 434
    Helixi45 – 539
    Helixi57 – 6812
    Beta strandi76 – 827
    Beta strandi85 – 906
    Helixi92 – 10615
    Helixi107 – 1093
    Turni115 – 1184
    Beta strandi120 – 1245
    Helixi136 – 15419
    Beta strandi158 – 1658
    Helixi170 – 18112
    Helixi183 – 19614
    Helixi203 – 22018
    Helixi222 – 2243
    Helixi225 – 23713
    Beta strandi238 – 2403
    Helixi243 – 26018
    Beta strandi265 – 2695
    Helixi270 – 2756
    Helixi278 – 28710
    Beta strandi296 – 2983
    Turni299 – 3024
    Beta strandi304 – 3074
    Turni309 – 3113
    Beta strandi313 – 3164
    Beta strandi319 – 3235
    Helixi331 – 34212
    Beta strandi351 – 3544
    Beta strandi356 – 3583
    Beta strandi360 – 3623
    Beta strandi377 – 3848
    Helixi385 – 3873
    Helixi388 – 40013
    Helixi404 – 4085
    Beta strandi410 – 4156
    Beta strandi418 – 4203
    Turni427 – 4348
    Helixi437 – 45519
    Helixi461 – 48121
    Helixi493 – 4964
    Beta strandi500 – 5034
    Helixi504 – 52320
    Helixi530 – 5367
    Helixi544 – 56522
    Helixi570 – 58920
    Helixi599 – 62022

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZUEX-ray2.00A1-629[»]
    2ZUFX-ray2.30A1-629[»]
    ProteinModelPortaliO59147.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO59147.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi128 – 13811"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247213.
    KOiK01887.
    OMAiNFERNSA.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 2 hits.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59147-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMEIRESVK ERIEEIIKEI APQWEGEIEL KETPDPKLGD FGTPIAFKLA    50
    KLLKRPPIEI AEKIVEKLKL NLPEGIKDVK AVNGYINVFI DYPHFARILI 100
    NDILAKGDRF GSSEIGKGKK VIVEHTSVNP TKPLHMGHAR NAILGDVMAR 150
    ILRFLGYEVE VQNYIDDLGI QFAQVYWGYL RLKEEFERIM NELRERGLKD 200
    NPIDHALGLL YVEVNRRLED NPELENEIRD IMKKLESGEL YGRKLAEEVV 250
    RAQMVTTYKL GVKYDLLVWE SDIVRRKLFE IALELLSKNE NFYIPSDGKY 300
    RGAFVMDLRK LFPDMKNPIL VLRRSDGTAT YTGKDIAYHL WKFGKIDVDL 350
    LYKEWDSTTW TTAPDGKSMP NKFGNANIVI NVIGAEQKHP QLAIKYALQL 400
    LGFEDAAANL YHLAYEHVER PEGKFSGRKG TWVGFTVDEV IQEAVKRARE 450
    LIEEKNPALS DEEKAEVAEK VGIGAIRYNL IKYSPDKKII FRWEDVLNFE 500
    GESAPYIQYA HARCSSILRK AEEEGIKVDP ETLFKNADFT KLSERERELV 550
    IMLSKFPRIV EQAGKDVKPH LIAWFANELA SLFNKFYMDH PVLKAEEGVR 600
    EARLLLVMAV EQVLKNALYL MGIEAPERM 629
    Length:629
    Mass (Da):72,340
    Last modified:August 1, 1998 - v1
    Checksum:i34CE2D841DBAD48A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30585.1.
    PIRiA71023.
    RefSeqiNP_143342.1. NC_000961.1.
    WP_010885558.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA30585; BAA30585; BAA30585.
    GeneIDi1443796.
    KEGGipho:PH1478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30585.1 .
    PIRi A71023.
    RefSeqi NP_143342.1. NC_000961.1.
    WP_010885558.1. NC_000961.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZUE X-ray 2.00 A 1-629 [» ]
    2ZUF X-ray 2.30 A 1-629 [» ]
    ProteinModelPortali O59147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH1478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA30585 ; BAA30585 ; BAA30585 .
    GeneIDi 1443796.
    KEGGi pho:PH1478.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247213.
    KOi K01887.
    OMAi NFERNSA.

    Enzyme and pathway databases

    BioCyci PHOR70601:GJWR-1477-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O59147.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 2 hits.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiSYR_PYRHO
    AccessioniPrimary (citable) accession number: O59147
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3