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O59147

- SYR_PYRHO

UniProt

O59147 - SYR_PYRHO

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1477-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:PH1478
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629Arginine--tRNA ligasePRO_0000151653Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1478.

Structurei

Secondary structure

1
629
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2015
Helixi36 – 383
Beta strandi40 – 434
Helixi45 – 539
Helixi57 – 6812
Beta strandi76 – 827
Beta strandi85 – 906
Helixi92 – 10615
Helixi107 – 1093
Turni115 – 1184
Beta strandi120 – 1245
Helixi136 – 15419
Beta strandi158 – 1658
Helixi170 – 18112
Helixi183 – 19614
Helixi203 – 22018
Helixi222 – 2243
Helixi225 – 23713
Beta strandi238 – 2403
Helixi243 – 26018
Beta strandi265 – 2695
Helixi270 – 2756
Helixi278 – 28710
Beta strandi296 – 2983
Turni299 – 3024
Beta strandi304 – 3074
Turni309 – 3113
Beta strandi313 – 3164
Beta strandi319 – 3235
Helixi331 – 34212
Beta strandi351 – 3544
Beta strandi356 – 3583
Beta strandi360 – 3623
Beta strandi377 – 3848
Helixi385 – 3873
Helixi388 – 40013
Helixi404 – 4085
Beta strandi410 – 4156
Beta strandi418 – 4203
Turni427 – 4348
Helixi437 – 45519
Helixi461 – 48121
Helixi493 – 4964
Beta strandi500 – 5034
Helixi504 – 52320
Helixi530 – 5367
Helixi544 – 56522
Helixi570 – 58920
Helixi599 – 62022

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZUEX-ray2.00A1-629[»]
2ZUFX-ray2.30A1-629[»]
ProteinModelPortaliO59147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59147.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 13811"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiNFERNSA.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59147-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMEIRESVK ERIEEIIKEI APQWEGEIEL KETPDPKLGD FGTPIAFKLA
60 70 80 90 100
KLLKRPPIEI AEKIVEKLKL NLPEGIKDVK AVNGYINVFI DYPHFARILI
110 120 130 140 150
NDILAKGDRF GSSEIGKGKK VIVEHTSVNP TKPLHMGHAR NAILGDVMAR
160 170 180 190 200
ILRFLGYEVE VQNYIDDLGI QFAQVYWGYL RLKEEFERIM NELRERGLKD
210 220 230 240 250
NPIDHALGLL YVEVNRRLED NPELENEIRD IMKKLESGEL YGRKLAEEVV
260 270 280 290 300
RAQMVTTYKL GVKYDLLVWE SDIVRRKLFE IALELLSKNE NFYIPSDGKY
310 320 330 340 350
RGAFVMDLRK LFPDMKNPIL VLRRSDGTAT YTGKDIAYHL WKFGKIDVDL
360 370 380 390 400
LYKEWDSTTW TTAPDGKSMP NKFGNANIVI NVIGAEQKHP QLAIKYALQL
410 420 430 440 450
LGFEDAAANL YHLAYEHVER PEGKFSGRKG TWVGFTVDEV IQEAVKRARE
460 470 480 490 500
LIEEKNPALS DEEKAEVAEK VGIGAIRYNL IKYSPDKKII FRWEDVLNFE
510 520 530 540 550
GESAPYIQYA HARCSSILRK AEEEGIKVDP ETLFKNADFT KLSERERELV
560 570 580 590 600
IMLSKFPRIV EQAGKDVKPH LIAWFANELA SLFNKFYMDH PVLKAEEGVR
610 620
EARLLLVMAV EQVLKNALYL MGIEAPERM
Length:629
Mass (Da):72,340
Last modified:August 1, 1998 - v1
Checksum:i34CE2D841DBAD48A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA30585.1.
PIRiA71023.
RefSeqiNP_143342.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30585; BAA30585; BAA30585.
GeneIDi1443796.
KEGGipho:PH1478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA30585.1 .
PIRi A71023.
RefSeqi NP_143342.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZUE X-ray 2.00 A 1-629 [» ]
2ZUF X-ray 2.30 A 1-629 [» ]
ProteinModelPortali O59147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH1478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA30585 ; BAA30585 ; BAA30585 .
GeneIDi 1443796.
KEGGi pho:PH1478.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247213.
KOi K01887.
OMAi NFERNSA.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-1477-MONOMER.

Miscellaneous databases

EvolutionaryTracei O59147.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiSYR_PYRHO
AccessioniPrimary (citable) accession number: O59147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3