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Protein
Submitted name:

Uncharacterized protein

Gene

PH1363

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451ATP; via amide nitrogenCombined sources
Binding sitei183 – 1831ATP; via amide nitrogen and carbonyl oxygenCombined sources
Binding sitei215 – 2151ATP; via carbonyl oxygenCombined sources
Binding sitei311 – 3111ATPCombined sources
Binding sitei351 – 3511ATPCombined sources
Binding sitei440 – 4401FMNCombined sources
Binding sitei446 – 4461FMN; via carbonyl oxygenCombined sources
Binding sitei479 – 4791FMNCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1192ATPCombined sources
Nucleotide bindingi137 – 1393ATPCombined sources
Nucleotide bindingi358 – 3614ATPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingCombined sources, Flavoprotein, FMNCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1371-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:PH1363Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi415 ↔ 454Combined sources

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1363.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y56X-ray2.86A1-493[»]
ProteinModelPortaliO59088.
SMRiO59088. Positions 3-492.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59088.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 257148FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini261 – 35393FAD/NAD-binding_domInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiarCOG01299. Archaea.
COG0446. LUCA.
HOGENOMiHOG000073903.
KOiK00302.
OMAiLAMGFCQ.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 2 hits.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

O59088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMRPLDLTE KRGKKVTIYF EGKELEAYEG EKLPVALLAN EIYWLTTSNE
60 70 80 90 100
GRKRGAFTFG PVPMTVNGVK GLEARRIKVK DGMKIERQGY YDFHEEPVVE
110 120 130 140 150
PGEIERVVVD VAIIGGGPAG IGAALELQQY LTVALIEERG WLGGDMWLKG
160 170 180 190 200
IKQEGFNKDS RKVVEELVGK LNENTKIYLE TSALGVFDKG EYFLVPVVRG
210 220 230 240 250
DKLIEILAKR VVLATGAIDS TMLFENNDMP GVFRRDFALE VMNVWEVAPG
260 270 280 290 300
RKVAVTGSKA DEVIQELERW GIDYVHIPNV KRVEGNEKVE RVIDMNNHEY
310 320 330 340 350
KVDALIFADG RRPDINPITQ AGGKLRFRRG YYSPVLDEYH RIKDGIYVAG
360 370 380 390 400
SAVSIKPHYA NYLEGKLVGA YILKEFGYDA QPCIYEEKLR EYEPESLSIP
410 420 430 440 450
RIPLDKFNLE DVQICGCDVS LKKVDEVIRK GITDLQIIKR LTHLAMGFCQ
460 470 480 490
GRYCLFNGAV VVSQRTGKKL SEIDLPVARS PIKNVKMGIL ARR
Length:493
Mass (Da):55,561
Last modified:August 1, 1998 - v1
Checksum:i0D0A77B4CE138117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30469.1.
PIRiE71008.

Genome annotation databases

EnsemblBacteriaiBAA30469; BAA30469; BAA30469.
KEGGipho:PH1363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30469.1.
PIRiE71008.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y56X-ray2.86A1-493[»]
ProteinModelPortaliO59088.
SMRiO59088. Positions 3-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30469; BAA30469; BAA30469.
KEGGipho:PH1363.

Phylogenomic databases

eggNOGiarCOG01299. Archaea.
COG0446. LUCA.
HOGENOMiHOG000073903.
KOiK00302.
OMAiLAMGFCQ.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1371-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO59088.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 2 hits.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3Imported.
  2. "Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii."
    Tsuge H., Kawakami R., Sakuraba H., Ago H., Miyano M., Aki K., Katunuma N., Ohshima T.
    J. Biol. Chem. 280:31045-31049(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) IN COMPLEX WITH ATP AND FMN, DISULFIDE BONDS.

Entry informationi

Entry nameiO59088_PYRHO
AccessioniPrimary (citable) accession number: O59088
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: April 13, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.