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O59080

- PDXS_PYRHO

UniProt

O59080 - PDXS_PYRHO

Protein

Pyridoxal biosynthesis lyase PdxS

Gene

pdxS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-iminoacetate synthase activity Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-1361-MONOMER.
    UniPathwayiUPA00245.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxal biosynthesis lyase PdxSUniRule annotation (EC:4.-.-.-UniRule annotation)
    Gene namesi
    Name:pdxSUniRule annotation
    Ordered Locus Names:PH1355
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Pyridoxal biosynthesis lyase PdxSPRO_0000109445Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with PdxT.UniRule annotation

    Protein-protein interaction databases

    IntActiO59080. 1 interaction.
    MINTiMINT-1501312.
    STRINGi70601.PH1355.

    Structurei

    Secondary structure

    1
    335
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 2119
    Turni22 – 254
    Beta strandi26 – 338
    Helixi34 – 4310
    Beta strandi46 – 505
    Helixi55 – 606
    Helixi70 – 778
    Beta strandi84 – 896
    Helixi93 – 10210
    Beta strandi105 – 1139
    Helixi124 – 1263
    Beta strandi131 – 1377
    Helixi138 – 14710
    Beta strandi150 – 1545
    Helixi164 – 18118
    Helixi185 – 19511
    Helixi197 – 2004
    Helixi201 – 2099
    Beta strandi221 – 2233
    Helixi228 – 24518
    Beta strandi249 – 2546
    Helixi261 – 2699
    Beta strandi273 – 2775
    Helixi279 – 2824
    Beta strandi283 – 2853
    Helixi287 – 29913
    Turni300 – 3023
    Helixi304 – 3129

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FIQX-ray2.70A/B/C/D/E/F1-335[»]
    4FIRX-ray3.10A/B/C/D/E/F1-335[»]
    ProteinModelPortaliO59080.
    SMRiO59080. Positions 12-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxS/SNZ family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0214.
    HOGENOMiHOG000227586.
    KOiK06215.
    OMAiNECQNTI.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    HAMAPiMF_01824. PdxS.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR001852. Snz1p/Sor1.
    IPR008867. ThiG.
    [Graphical view]
    PfamiPF01680. SOR_SNZ. 1 hit.
    PF05690. ThiG. 1 hit.
    [Graphical view]
    PIRSFiPIRSF029271. Pdx1. 1 hit.
    SUPFAMiSSF51366. SSF51366. 2 hits.
    TIGRFAMsiTIGR00343. TIGR00343. 1 hit.
    PROSITEiPS01235. PDXS_SNZ_1. 1 hit.
    PS51129. PDXS_SNZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O59080-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKLKIIMEK GTERLKRGFA KMVKGGVIMD VTNAEQARIA EEAGAVAVMA    50
    LHKVPADIRK AGGVARMAPV EKIQEIMDAV TIPVMAKCRI GHEAEARILE 100
    ALGVDMIDES EVLTPADPFF HIYKKKFTAP FVCGARNLGE AVRRIWEGAA 150
    MIRTKGEAGT GNIIEAVRHV RLVNENIRLI QRMTDEEIYG VAEKFAEPYL 200
    RLAFSVKEIS GLPKRVLENE PIYEGFTYRE IVEDIYKILL EIKKLGRLPV 250
    VNFAAGGVAT PADAALMMAM GMDGVFVGSG IFKSSNPPKM ARAIVEAVNH 300
    WDEPDVLAEI SREIGEPMRG QAIEELQVRM EERGI 335
    Length:335
    Mass (Da):37,014
    Last modified:August 1, 1998 - v1
    Checksum:iD5E178BB654E5196
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30461.1.
    PIRiE71007.
    RefSeqiNP_143237.1. NC_000961.1.
    WP_010885443.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA30461; BAA30461; BAA30461.
    GeneIDi1443680.
    KEGGipho:PH1355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30461.1 .
    PIRi E71007.
    RefSeqi NP_143237.1. NC_000961.1.
    WP_010885443.1. NC_000961.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FIQ X-ray 2.70 A/B/C/D/E/F 1-335 [» ]
    4FIR X-ray 3.10 A/B/C/D/E/F 1-335 [» ]
    ProteinModelPortali O59080.
    SMRi O59080. Positions 12-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O59080. 1 interaction.
    MINTi MINT-1501312.
    STRINGi 70601.PH1355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA30461 ; BAA30461 ; BAA30461 .
    GeneIDi 1443680.
    KEGGi pho:PH1355.

    Phylogenomic databases

    eggNOGi COG0214.
    HOGENOMi HOG000227586.
    KOi K06215.
    OMAi NECQNTI.

    Enzyme and pathway databases

    UniPathwayi UPA00245 .
    BioCyci PHOR70601:GJWR-1361-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    HAMAPi MF_01824. PdxS.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR001852. Snz1p/Sor1.
    IPR008867. ThiG.
    [Graphical view ]
    Pfami PF01680. SOR_SNZ. 1 hit.
    PF05690. ThiG. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF029271. Pdx1. 1 hit.
    SUPFAMi SSF51366. SSF51366. 2 hits.
    TIGRFAMsi TIGR00343. TIGR00343. 1 hit.
    PROSITEi PS01235. PDXS_SNZ_1. 1 hit.
    PS51129. PDXS_SNZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiPDXS_PYRHO
    AccessioniPrimary (citable) accession number: O59080
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3