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O59080

- PDXS_PYRHO

UniProt

O59080 - PDXS_PYRHO

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Protein

Pyridoxal biosynthesis lyase PdxS

Gene

pdxS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-iminoacetate synthase activity Source: InterPro

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1361-MONOMER.
UniPathwayiUPA00245.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal biosynthesis lyase PdxSUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:pdxSUniRule annotation
Ordered Locus Names:PH1355
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Pyridoxal biosynthesis lyase PdxSPRO_0000109445Add
BLAST

Interactioni

Subunit structurei

Forms a complex with PdxT.UniRule annotation

Protein-protein interaction databases

IntActiO59080. 1 interaction.
MINTiMINT-1501312.
STRINGi70601.PH1355.

Structurei

Secondary structure

1
335
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2119Combined sources
Turni22 – 254Combined sources
Beta strandi26 – 338Combined sources
Helixi34 – 4310Combined sources
Beta strandi46 – 505Combined sources
Helixi55 – 606Combined sources
Helixi70 – 778Combined sources
Beta strandi84 – 896Combined sources
Helixi93 – 10210Combined sources
Beta strandi105 – 1139Combined sources
Helixi124 – 1263Combined sources
Beta strandi131 – 1377Combined sources
Helixi138 – 14710Combined sources
Beta strandi150 – 1545Combined sources
Helixi164 – 18118Combined sources
Helixi185 – 19511Combined sources
Helixi197 – 2004Combined sources
Helixi201 – 2099Combined sources
Beta strandi221 – 2233Combined sources
Helixi228 – 24518Combined sources
Beta strandi249 – 2546Combined sources
Helixi261 – 2699Combined sources
Beta strandi273 – 2775Combined sources
Helixi279 – 2824Combined sources
Beta strandi283 – 2853Combined sources
Helixi287 – 29913Combined sources
Turni300 – 3023Combined sources
Helixi304 – 3129Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FIQX-ray2.70A/B/C/D/E/F1-335[»]
4FIRX-ray3.10A/B/C/D/E/F1-335[»]
ProteinModelPortaliO59080.
SMRiO59080. Positions 12-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxS/SNZ family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0214.
HOGENOMiHOG000227586.
KOiK06215.
OMAiNECQNTI.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_01824. PdxS.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR001852. Snz1p/Sor1.
IPR008867. ThiG.
[Graphical view]
PfamiPF01680. SOR_SNZ. 1 hit.
PF05690. ThiG. 1 hit.
[Graphical view]
PIRSFiPIRSF029271. Pdx1. 1 hit.
SUPFAMiSSF51366. SSF51366. 2 hits.
TIGRFAMsiTIGR00343. TIGR00343. 1 hit.
PROSITEiPS01235. PDXS_SNZ_1. 1 hit.
PS51129. PDXS_SNZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O59080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLKIIMEK GTERLKRGFA KMVKGGVIMD VTNAEQARIA EEAGAVAVMA
60 70 80 90 100
LHKVPADIRK AGGVARMAPV EKIQEIMDAV TIPVMAKCRI GHEAEARILE
110 120 130 140 150
ALGVDMIDES EVLTPADPFF HIYKKKFTAP FVCGARNLGE AVRRIWEGAA
160 170 180 190 200
MIRTKGEAGT GNIIEAVRHV RLVNENIRLI QRMTDEEIYG VAEKFAEPYL
210 220 230 240 250
RLAFSVKEIS GLPKRVLENE PIYEGFTYRE IVEDIYKILL EIKKLGRLPV
260 270 280 290 300
VNFAAGGVAT PADAALMMAM GMDGVFVGSG IFKSSNPPKM ARAIVEAVNH
310 320 330
WDEPDVLAEI SREIGEPMRG QAIEELQVRM EERGI
Length:335
Mass (Da):37,014
Last modified:August 1, 1998 - v1
Checksum:iD5E178BB654E5196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30461.1.
PIRiE71007.
RefSeqiNP_143237.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30461; BAA30461; BAA30461.
GeneIDi1443680.
KEGGipho:PH1355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30461.1 .
PIRi E71007.
RefSeqi NP_143237.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FIQ X-ray 2.70 A/B/C/D/E/F 1-335 [» ]
4FIR X-ray 3.10 A/B/C/D/E/F 1-335 [» ]
ProteinModelPortali O59080.
SMRi O59080. Positions 12-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O59080. 1 interaction.
MINTi MINT-1501312.
STRINGi 70601.PH1355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA30461 ; BAA30461 ; BAA30461 .
GeneIDi 1443680.
KEGGi pho:PH1355.

Phylogenomic databases

eggNOGi COG0214.
HOGENOMi HOG000227586.
KOi K06215.
OMAi NECQNTI.

Enzyme and pathway databases

UniPathwayi UPA00245 .
BioCyci PHOR70601:GJWR-1361-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_01824. PdxS.
InterProi IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR001852. Snz1p/Sor1.
IPR008867. ThiG.
[Graphical view ]
Pfami PF01680. SOR_SNZ. 1 hit.
PF05690. ThiG. 1 hit.
[Graphical view ]
PIRSFi PIRSF029271. Pdx1. 1 hit.
SUPFAMi SSF51366. SSF51366. 2 hits.
TIGRFAMsi TIGR00343. TIGR00343. 1 hit.
PROSITEi PS01235. PDXS_SNZ_1. 1 hit.
PS51129. PDXS_SNZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiPDXS_PYRHO
AccessioniPrimary (citable) accession number: O59080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3