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Protein
Submitted name:

439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme]

Gene

PH1275

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74NADCombined sources1
Binding sitei219NADCombined sources1
Binding sitei297NADCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 197NADCombined sources2
Nucleotide bindingi326 – 328NADCombined sources3

GO - Molecular functioni

Keywordsi

LigandNADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1273-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme]Imported
Gene namesi
Ordered Locus Names:PH1275Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1275.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WW8X-ray2.50A/B1-439[»]
2DVMX-ray1.60A/B/C/D1-439[»]
ProteinModelPortaliO59029.
SMRiO59029.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59029.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 150malicInterPro annotationAdd BLAST134
Domaini162 – 393Malic_MInterPro annotationAdd BLAST232

Phylogenomic databases

eggNOGiarCOG00853. Archaea.
COG0281. LUCA.
HOGENOMiHOG000132447.
KOiK00027.
OMAiILFKQFG.
OrthoDBiPOG093Z01QY.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
InterProiView protein in InterPro
IPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF00390. malic. 1 hit.
PF03949. Malic_M. 2 hits.
PIRSFiPIRSF000106. ME. 1 hit.
SMARTiView protein in SMART
SM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00331. MALIC_ENZYMES. 1 hit.

Sequencei

Sequence statusi: Complete.

O59029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIREKALEFH KNNFPGNGKI EVIPKVSLES REELTLAYTP GVAEPCKEIA
60 70 80 90 100
RDPGKVYEYT SKGNLVAVVS DGSRILGLGN IGPLAGLPVM EGKALLFKRF
110 120 130 140 150
GGVDAFPIMI KEQEPNKFID IVKAIAPTFG GINLEDIASP KCFYILERLR
160 170 180 190 200
EELDIPVFHD DQQGTAAVVL AGLLNALKVV GKKISEITLA LFGAGAAGFA
210 220 230 240 250
TLRILTEAGV KPENVRVVEL VNGKPRILTS DLDLEKLFPY RGWLLKKTNG
260 270 280 290 300
ENIEGGPQEA LKDADVLISF TRPGPGVIKP QWIEKMNEDA IVFPLANPVP
310 320 330 340 350
EILPEEAKKA GARIVATGRS DYPNQINNLL GFPGIFRGAL DVRARTITDS
360 370 380 390 400
MIIAAAKAIA SIVEEPSEEN IIPSPLNPIV YAREARAVAE EAMKEGVART
410 420 430
KVKGEWVEEH TIRLIEFYEN VIAPINKKRR EYSKAITRA
Length:439
Mass (Da):48,004
Last modified:August 1, 1998 - v1
Checksum:i64CD15417DE9C669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30378.1.
PIRiH71072.
RefSeqiWP_010885363.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30378; BAA30378; BAA30378.
GeneIDi1443599.
KEGGipho:PH1275.

Similar proteinsi

Entry informationi

Entry nameiO59029_PYRHO
AccessioniPrimary (citable) accession number: O59029
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: August 30, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported