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O59028

- MDH_PYRHO

UniProt

O59028 - MDH_PYRHO

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:PH1277
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Malate dehydrogenasePRO_0000083829Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1277.

Structurei

Secondary structure

1
360
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 144Combined sources
Helixi16 – 2914Combined sources
Helixi34 – 4916Combined sources
Helixi53 – 553Combined sources
Helixi57 – 593Combined sources
Helixi60 – 689Combined sources
Beta strandi71 – 755Combined sources
Beta strandi79 – 846Combined sources
Beta strandi87 – 915Combined sources
Helixi97 – 11519Combined sources
Beta strandi116 – 12510Combined sources
Helixi132 – 1398Combined sources
Turni140 – 1423Combined sources
Beta strandi143 – 1497Combined sources
Beta strandi170 – 1745Combined sources
Beta strandi177 – 1793Combined sources
Beta strandi181 – 1855Combined sources
Beta strandi187 – 1904Combined sources
Turni192 – 1943Combined sources
Beta strandi215 – 2173Combined sources
Turni223 – 2275Combined sources
Beta strandi236 – 2383Combined sources
Helixi242 – 25615Combined sources
Turni257 – 2615Combined sources
Helixi265 – 2673Combined sources
Beta strandi278 – 2858Combined sources
Helixi287 – 2893Combined sources
Helixi293 – 30816Combined sources
Helixi324 – 33613Combined sources
Beta strandi338 – 3414Combined sources
Helixi342 – 35514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V9NX-ray2.10A1-360[»]
ProteinModelPortaliO59028.
SMRiO59028. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59028.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family.Curated

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
OMAiIGTYGEM.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.

Sequencei

Sequence statusi: Complete.

O59028-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFEKGYVDEN YIRVPKDRLF SFIVRVLTKL GVPEEDAKIV ADNLVMADLR
60 70 80 90 100
GVESHGVQRL KRYVDGIISG GVNLHPKIRV IREGPSYALI DGDEGLGQVV
110 120 130 140 150
GYRSMKLAIK KAKDTGIGIV IARNSNHYGI AGYYALMAAE EGMIGISMTN
160 170 180 190 200
SRPLVAPTGG IERILGTNPI ALAAPTKDKP FLLDMATSVV PIGKLEVYRR
210 220 230 240 250
KGKDIPEGWA INREGNITTK VEEVFNGGAL LPLGGFGELL GGHKGYGLSL
260 270 280 290 300
MVDILSGILS GGTWSKYVKN TSEKGSNVCH FFMVIDIEHF IPLEEFKEKI
310 320 330 340 350
SQMIEEIKSS RKHPEFERIW IHGEKGFLTM ETRLKLGIPI YRKVLEELNE
360
IAKRVGVEGL
Length:360
Mass (Da):39,751
Last modified:August 1, 1998 - v1
Checksum:i6E9D8B16ECDE6E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30380.1.
PIRiB71073.
RefSeqiNP_143166.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30380; BAA30380; BAA30380.
GeneIDi1443600.
KEGGipho:PH1277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30380.1 .
PIRi B71073.
RefSeqi NP_143166.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1V9N X-ray 2.10 A 1-360 [» ]
ProteinModelPortali O59028.
SMRi O59028. Positions 1-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH1277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA30380 ; BAA30380 ; BAA30380 .
GeneIDi 1443600.
KEGGi pho:PH1277.

Phylogenomic databases

eggNOGi COG2055.
HOGENOMi HOG000173270.
OMAi IGTYGEM.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-1275-MONOMER.

Miscellaneous databases

EvolutionaryTracei O59028.

Family and domain databases

InterProi IPR003767. Malate/L-lactate_DH.
[Graphical view ]
PANTHERi PTHR11091. PTHR11091. 1 hit.
Pfami PF02615. Ldh_2. 1 hit.
[Graphical view ]
SUPFAMi SSF89733. SSF89733. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiMDH_PYRHO
AccessioniPrimary (citable) accession number: O59028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3