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O59028

- MDH_PYRHO

UniProt

O59028 - MDH_PYRHO

Protein

Malate dehydrogenase

Gene

mdh

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-1275-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Ordered Locus Names:PH1277
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Malate dehydrogenasePRO_0000083829Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi70601.PH1277.

    Structurei

    Secondary structure

    1
    360
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi11 – 144
    Helixi16 – 2914
    Helixi34 – 4916
    Helixi53 – 553
    Helixi57 – 593
    Helixi60 – 689
    Beta strandi71 – 755
    Beta strandi79 – 846
    Beta strandi87 – 915
    Helixi97 – 11519
    Beta strandi116 – 12510
    Helixi132 – 1398
    Turni140 – 1423
    Beta strandi143 – 1497
    Beta strandi170 – 1745
    Beta strandi177 – 1793
    Beta strandi181 – 1855
    Beta strandi187 – 1904
    Turni192 – 1943
    Beta strandi215 – 2173
    Turni223 – 2275
    Beta strandi236 – 2383
    Helixi242 – 25615
    Turni257 – 2615
    Helixi265 – 2673
    Beta strandi278 – 2858
    Helixi287 – 2893
    Helixi293 – 30816
    Helixi324 – 33613
    Beta strandi338 – 3414
    Helixi342 – 35514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V9NX-ray2.10A1-360[»]
    ProteinModelPortaliO59028.
    SMRiO59028. Positions 1-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO59028.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH2/MDH2 oxidoreductase family.Curated

    Phylogenomic databases

    eggNOGiCOG2055.
    HOGENOMiHOG000173270.
    OMAiIGTYGEM.

    Family and domain databases

    InterProiIPR003767. Malate/L-lactate_DH.
    [Graphical view]
    PANTHERiPTHR11091. PTHR11091. 1 hit.
    PfamiPF02615. Ldh_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF89733. SSF89733. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O59028-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEKGYVDEN YIRVPKDRLF SFIVRVLTKL GVPEEDAKIV ADNLVMADLR    50
    GVESHGVQRL KRYVDGIISG GVNLHPKIRV IREGPSYALI DGDEGLGQVV 100
    GYRSMKLAIK KAKDTGIGIV IARNSNHYGI AGYYALMAAE EGMIGISMTN 150
    SRPLVAPTGG IERILGTNPI ALAAPTKDKP FLLDMATSVV PIGKLEVYRR 200
    KGKDIPEGWA INREGNITTK VEEVFNGGAL LPLGGFGELL GGHKGYGLSL 250
    MVDILSGILS GGTWSKYVKN TSEKGSNVCH FFMVIDIEHF IPLEEFKEKI 300
    SQMIEEIKSS RKHPEFERIW IHGEKGFLTM ETRLKLGIPI YRKVLEELNE 350
    IAKRVGVEGL 360
    Length:360
    Mass (Da):39,751
    Last modified:August 1, 1998 - v1
    Checksum:i6E9D8B16ECDE6E6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30380.1.
    PIRiB71073.
    RefSeqiNP_143166.1. NC_000961.1.
    WP_010885364.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA30380; BAA30380; BAA30380.
    GeneIDi1443600.
    KEGGipho:PH1277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30380.1 .
    PIRi B71073.
    RefSeqi NP_143166.1. NC_000961.1.
    WP_010885364.1. NC_000961.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V9N X-ray 2.10 A 1-360 [» ]
    ProteinModelPortali O59028.
    SMRi O59028. Positions 1-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH1277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA30380 ; BAA30380 ; BAA30380 .
    GeneIDi 1443600.
    KEGGi pho:PH1277.

    Phylogenomic databases

    eggNOGi COG2055.
    HOGENOMi HOG000173270.
    OMAi IGTYGEM.

    Enzyme and pathway databases

    BioCyci PHOR70601:GJWR-1275-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O59028.

    Family and domain databases

    InterProi IPR003767. Malate/L-lactate_DH.
    [Graphical view ]
    PANTHERi PTHR11091. PTHR11091. 1 hit.
    Pfami PF02615. Ldh_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89733. SSF89733. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiMDH_PYRHO
    AccessioniPrimary (citable) accession number: O59028
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3