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Protein

Malate dehydrogenase

Gene

mdh

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1236-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:PH1277
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838291 – 360Malate dehydrogenaseAdd BLAST360

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1277

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 14Combined sources4
Helixi16 – 29Combined sources14
Helixi34 – 49Combined sources16
Helixi53 – 55Combined sources3
Helixi57 – 59Combined sources3
Helixi60 – 68Combined sources9
Beta strandi71 – 75Combined sources5
Beta strandi79 – 84Combined sources6
Beta strandi87 – 91Combined sources5
Helixi97 – 115Combined sources19
Beta strandi116 – 125Combined sources10
Helixi132 – 139Combined sources8
Turni140 – 142Combined sources3
Beta strandi143 – 149Combined sources7
Beta strandi170 – 174Combined sources5
Beta strandi177 – 179Combined sources3
Beta strandi181 – 185Combined sources5
Beta strandi187 – 190Combined sources4
Turni192 – 194Combined sources3
Beta strandi215 – 217Combined sources3
Turni223 – 227Combined sources5
Beta strandi236 – 238Combined sources3
Helixi242 – 256Combined sources15
Turni257 – 261Combined sources5
Helixi265 – 267Combined sources3
Beta strandi278 – 285Combined sources8
Helixi287 – 289Combined sources3
Helixi293 – 308Combined sources16
Helixi324 – 336Combined sources13
Beta strandi338 – 341Combined sources4
Helixi342 – 355Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V9NX-ray2.10A1-360[»]
ProteinModelPortaliO59028
SMRiO59028
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO59028

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family.Curated

Phylogenomic databases

eggNOGiarCOG04874 Archaea
COG2055 LUCA
HOGENOMiHOG000173270
OMAiNTEPAMA
OrthoDBiPOG093Z05AA

Family and domain databases

InterProiView protein in InterPro
IPR036111 Mal/L-sulfo/L-lacto_DH-like_sf
IPR003767 Malate/L-lactate_DH-like
PANTHERiPTHR11091 PTHR11091, 1 hit
PfamiView protein in Pfam
PF02615 Ldh_2, 1 hit
SUPFAMiSSF89733 SSF89733, 1 hit

Sequencei

Sequence statusi: Complete.

O59028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKGYVDEN YIRVPKDRLF SFIVRVLTKL GVPEEDAKIV ADNLVMADLR
60 70 80 90 100
GVESHGVQRL KRYVDGIISG GVNLHPKIRV IREGPSYALI DGDEGLGQVV
110 120 130 140 150
GYRSMKLAIK KAKDTGIGIV IARNSNHYGI AGYYALMAAE EGMIGISMTN
160 170 180 190 200
SRPLVAPTGG IERILGTNPI ALAAPTKDKP FLLDMATSVV PIGKLEVYRR
210 220 230 240 250
KGKDIPEGWA INREGNITTK VEEVFNGGAL LPLGGFGELL GGHKGYGLSL
260 270 280 290 300
MVDILSGILS GGTWSKYVKN TSEKGSNVCH FFMVIDIEHF IPLEEFKEKI
310 320 330 340 350
SQMIEEIKSS RKHPEFERIW IHGEKGFLTM ETRLKLGIPI YRKVLEELNE
360
IAKRVGVEGL
Length:360
Mass (Da):39,751
Last modified:August 1, 1998 - v1
Checksum:i6E9D8B16ECDE6E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30380.1
PIRiB71073
RefSeqiWP_010885364.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30380; BAA30380; BAA30380
GeneIDi1443600
KEGGipho:PH1277

Similar proteinsi

Entry informationi

Entry nameiMDH_PYRHO
AccessioniPrimary (citable) accession number: O59028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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