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Protein

Carbamate kinase

Gene

cpkA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1239-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase (EC:2.7.2.2)
Alternative name(s):
Carbamate kinase-like carbamoylphosphate synthase
Gene namesi
Name:cpkA
Ordered Locus Names:PH1282
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851501 – 314Carbamate kinaseAdd BLAST314

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1282

Structurei

3D structure databases

ProteinModelPortaliO59023
SMRiO59023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG00863 Archaea
COG0549 LUCA
HOGENOMiHOG000277403
KOiK00926
OMAiPIKWLLE
OrthoDBiPOG093Z06C8

Family and domain databases

CDDicd04235 AAK_CK, 1 hit
Gene3Di3.40.1160.10, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR003964 Carb_kinase
PANTHERiPTHR30409 PTHR30409, 1 hit
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF000723 Carbamate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR00746 arcC, 1 hit

Sequencei

Sequence statusi: Complete.

O59023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERVVIALG GNALQQRGQK GTYDEMMENV RKTAKQIAEI IARGYEVVIT
60 70 80 90 100
HGNGPQVGTI LLHMDAGQSL HGIPAQPMDV AGAMSQGWIG YMIQQALRNE
110 120 130 140 150
LRKRGIEKEV VTIITQTIVD KKDPAFQNPT KPVGPFYDEK TAKKLAKEKG
160 170 180 190 200
WVVKEDAGRG WRRVVPSPDP KGHVEAETIR RLVESGIIVI ASGGGGVPVI
210 220 230 240 250
EENGEIKGVE AVIDKDLAGE KLAEEVNADI LMILTDVNGA ALYYGTEKET
260 270 280 290 300
WLRNVKVEEL EKYYQEGHFK AGSMGPKVLA AIRFIKNGGK RAIIAHLEKA
310
VEALEGKTGT QVTP
Length:314
Mass (Da):34,235
Last modified:August 1, 1998 - v1
Checksum:iBCE87715B72E8CAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30385.1
PIRiG71073
RefSeqiWP_010885368.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30385; BAA30385; BAA30385
GeneIDi1443604
KEGGipho:PH1282

Similar proteinsi

Entry informationi

Entry nameiCPKA_PYRHO
AccessioniPrimary (citable) accession number: O59023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health