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Protein

Carbamate kinase

Gene

cpkA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase (EC:2.7.2.2)
Alternative name(s):
Carbamate kinase-like carbamoylphosphate synthase
Gene namesi
Name:cpkA
Ordered Locus Names:PH1282
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Carbamate kinasePRO_0000185150Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1282.

Structurei

3D structure databases

ProteinModelPortaliO59023.
SMRiO59023. Positions 3-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG00863. Archaea.
COG0549. LUCA.
HOGENOMiHOG000277403.
KOiK00926.
OMAiQIAKIHP.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.

Sequencei

Sequence statusi: Complete.

O59023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERVVIALG GNALQQRGQK GTYDEMMENV RKTAKQIAEI IARGYEVVIT
60 70 80 90 100
HGNGPQVGTI LLHMDAGQSL HGIPAQPMDV AGAMSQGWIG YMIQQALRNE
110 120 130 140 150
LRKRGIEKEV VTIITQTIVD KKDPAFQNPT KPVGPFYDEK TAKKLAKEKG
160 170 180 190 200
WVVKEDAGRG WRRVVPSPDP KGHVEAETIR RLVESGIIVI ASGGGGVPVI
210 220 230 240 250
EENGEIKGVE AVIDKDLAGE KLAEEVNADI LMILTDVNGA ALYYGTEKET
260 270 280 290 300
WLRNVKVEEL EKYYQEGHFK AGSMGPKVLA AIRFIKNGGK RAIIAHLEKA
310
VEALEGKTGT QVTP
Length:314
Mass (Da):34,235
Last modified:August 1, 1998 - v1
Checksum:iBCE87715B72E8CAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30385.1.
PIRiG71073.
RefSeqiWP_010885368.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30385; BAA30385; BAA30385.
GeneIDi1443604.
KEGGipho:PH1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30385.1.
PIRiG71073.
RefSeqiWP_010885368.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO59023.
SMRiO59023. Positions 3-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30385; BAA30385; BAA30385.
GeneIDi1443604.
KEGGipho:PH1282.

Phylogenomic databases

eggNOGiarCOG00863. Archaea.
COG0549. LUCA.
HOGENOMiHOG000277403.
KOiK00926.
OMAiQIAKIHP.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1279-MONOMER.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPKA_PYRHO
AccessioniPrimary (citable) accession number: O59023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.